Statines - Lipitor nieuws
Er is geen overtuigend bewijs voor
preventief nut Lipitor bij vrouwen
Lipitor has been the top-selling drug in
the world and has accounted for over $12 billion in annual sales. It has been prescribed
to both men and women to lower cholesterol and reduce the risk of heart attack and stroke
in patients with common risk factors for heart disease. However, a new study appearing in
the Journal of Empirical Legal Studies was unable to find high quality clinical evidence
documenting reduced heart attack risk for women in a primary prevention context.
Furthermore, advertising omits label information relevant to women. Theodore Eisenberg of
Cornell Law School and Martin T. Wells of Cornell University assembled studies for a meta
analysis of drugs? effects on cardiovascular risk, taking into account all relevant
studies reporting risks for both men and women.
Farma bedrijven woest op nieuwe
In Amerika is er een nieuwe website waarop
artsen ervaringen met medicijnen bij hun patiŽnten kunnen uitwisselen. Het vervelende
voor de industrie is nu echter dat deze artsen sneller op de hoogte zijn van mogelijke
complicaties van medicijnen. Voorbeeld: 3 artsen melden dat Lipitor gebruikers
nachtmerries kregen en meteen werd er onder de gebruikers een onderzoek ingesteld of er
meer artsen waren die dit bemerkt hadden, een nachtmerrie voor de op geld beluste farmacie
die de informatie stroom richting de arts niet meer in de grip heeft. De artsen zijn te
snel op de hoogte van problemen van een bepaald medicijn en dit is slecht voor de
medicijnmannen. Bij het verhaal van Lipitor bleek maar liefst 33% van 750 deelnemende
artsen ook patiŽnten te hebben met nachtmerries. Ik vermoed dat de fabrikant intussen
zelf ook last van deze genoemde klacht zal krijgen.....internet is slecht voor de
Pfizer met Lipitor voor de rechter
Pfizer komt in Amerika voor de rechter ivm
de cholesterol remmer Lipitor.
Er zijn twee aanklachten:
- Geheugen verlies
- Schade aan spieren
De rechtzaken zijn ingediend door een oud
verzekeringsmedewerken en een advocaat die Pfizer voor de rechter hebben gedaagd vanwege
diverse gezondheidsklanten zoals geheugen verlies, zenuwgestel schade en spierkracht
verlies in armen en benen.
De klagers vinden dat de fabrikant
patiŽnten en medische professionals te weinig heeft verteld over de serieuze bijwerkingen
Personal Injury Lawsuits Filed
Against Pfizer Over Undisclosed Risks of
Blockbuster Cholesterol Drug Lipitor
Suits Allege Pfizer's Deceptive Marketing
Practices and Failure to Warn
Physicians and Patients About Serious Health Problems Tied to Lipitor Use;
Mother of a Teenage Suicide Points to
Statin Usage; Patients and Family
Members to Meet With U.S. Senate Finance Committee to Ask for More Stringent Warnings on
A pair of personal injury lawsuits has
been filed against Pfizer Inc. charging
the giant drug company with concealing serious health risks associated with
its blockbuster anti-cholesterol medication Lipitor.
The suits accuse Pfizer of deceptive marketing practices and allege that the
company promoted Lipitor as a safe drug with minimal health risks while
knowingly failing to warn physicians and patients of Lipitor's more
dangerous side effects, including nerve damage, memory loss and other
Aggressive marketing of Lipitor -- supported by physician "education" groups
funded by Pfizer -- has helped secure its status as the best-selling drug in
the world, with sales exceeding $12 billion in 2005.
The two new lawsuits were filed in New York State Supreme Court on behalf of Charles M.
Wilson, a 60-year-old former insurance executive from Atlanta and Michael Mazzariello, a
47-year old attorney from New York.
Mr. Wilson has suffered a series of irreversible health problems, which he
asserts were caused by taking Lipitor during a 17 month period in 2002 and
2003. Among the damages he alleges were provoked by Lipitor are peripheral
nervous system damage (peripheral neuropathy), inflammatory demyelinating
polyneuropathy, and memory loss. Nearly three years after discontinuing the
medication, he continues to suffer from loss of balance, burning in the
hands and feet, and bouts of fatigue. He was forced to leave his job as a
result of his injuries.
Mr. Mazzariello, who practiced criminal trial law throughout New York State,
suffered debilitating injuries to various muscles forcing him to walk with a
cane and endure repeated hospitalizations. He also suffered extensive memory loss, which
he attributes to his statin usage.
The two men announced their lawsuit at a news conference in New York City, during which
they were joined by individuals from other parts of the country describing their own
personal health problems associated with Lipitor. Included in the group was Susan Nelson
of Bainbridge Island, Washington. Mrs. Nelson claims that her teenage son Jacob, a gifted
gymnast, began experiencing severe bouts of depression and violent nightmares after he
began a course of Lipitor to reduce his cholesterol in 2001. He committed suicide in 2003.
"It is very clear to me that the culprit of the depressions ... and suicide
of my son is due to the side effects of the cholesterol-lowering drugs
Mevacor and Lipitor," Mrs. Nelson wrote in a letter. "Had I known that the
nightmares, lack of concentration, and depression... could have been warning signs for
side effects of these medications, the doctors, my husband, son and I could have taken
another course and gotten (him) off these supposed wonder drugs! There is no doubt my son
Jake would be alive today had I been warned... "
"Pfizer has aggressively promoted Lipitor to consumers as a safe drug with
manageable and limited side effects despite apparently knowing and
fraudulently concealing the serious health risks associated with statins,"
said attorney Mark Jay Krum, who represents Mr. Wilson and Mr. Mazzariello.
"The complaints allege that the company has negligently misled both
physicians and patients and is apparently more concerned with driving sales
of Lipitor than with the safety of its users."
The complaints note that despite receiving two letters since 2001 from the
Food & Drug Administration expressing concerns that Lipitor's marketing
material did not reflect the heath risks the drug poses, Pfizer promoted the
drug as virtually symptom free, stating on its Web site: "In fact, in some
clinical studies, Lipitor has been proven to be as safe as taking a sugar
Statins work by blocking certain cholesterol-producing enzymes, but a number of physicians
have warned that the process to curtail cholesterol inhibits other metabolic functions
that can lead to a host of medical issues. One doctor who has written extensively on the
risks of statin usage declared
recently, "The inevitability of significant, serious and even lethal side
effects has been knowingly accepted by the manufacturer."
That Pfizer was well aware of the cognitive risks associated with its statin
drug is evident in a letter by a Pfizer physician dated October 2003. "A
search of our postmarketing safety surveillance datatbase for Lipitor
revealed that we have received spontaneous reports of amnesia and thinking
abnormal since the market introduction of Lipitor," the doctor wrote. Pfizer
conducted its own controlled studies of cognitive function and found a .3%
incidence of amnesia from Lipitor and a .2% rate of what the company called
"abnormal thinking." Together, those two outcomes would translate into more than
100,000 cases of mental impairment given the current population of Lipitor users.
This past March, Pfizer was sued by a group of union and employee insurance plans
who charged the company with fraudulently marketing Lipitor for off-label uses not
approved by FDA protocols for cholesterol treatment. The employee and third-party health
plans allege that Pfizer's off-label
promotion of Lipitor has resulted in billions of dollars in unnecessary
prescriptions for the drug. The health plans challenged Pfizer's creation
and funding of "educational" organizations offering physicians continuing
medical education courses and publication of articles extolling the
off-label usage. There is also a class action pending against Pfizer for its
marketing of Lipitor to women.
The latest personal injury suits contend that Lipitor is defectively
designed and inadequately tested, and lacks the proper patient warnings as
to its dangers. At the news conference, Mr. Wilson and Mr. Mazzariello were
joined by several other patients who described experiencing similar serious
health problems from Lipitor use, including a former airline pilot from
Washington, D.C. who believes his loss of motor function and severe chronic
pain were caused by statin usage; and a former Army helicopter engineer from Corpus
Christi, Texas, who believes that his memory loss and disorientation are the result of
Also participating to discuss the effects of statin drugs was Dr. Paul
Rosch, president of the American Institute of Stress and a clinical
professor of Medicine and Psychiatry at New York Medical College.
"Statin drugs make enormous amounts of money for the pharmaceutical
industry, the power and influence of which should not be underestimated,"
said Dr. Peter Langsjoen, a noted cardiologist from Texas who attended the
news conference. "By lowering cholesterol they give doctors and their
patients a false sense of security by treating 'cholesterol neurosis,' but
statin adverse effects are insidious and are often delayed for several
The group will meet with members of the Senate Finance Committee in
Washington, D.C. on Friday to discuss their concerns over potential harmful
effects of Lipitor and to call for stricter federal health warnings on
Goed voor hart/bloedvaten?