borstkanker en voeding


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Borstkanker


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Borstkanker en chemicaliŽn

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Deodorants veroorzaken toch borstkanker !! KWF ontkent nog altijd verband

Vrouwen die vaak met goedaardige knobbeltjes of cysten in hun borsten kampen, hebben meer kans op kanker. Steeds meer Britse artsen denken dat het regelmatige gebruik van antitranspiratie deodorants leidt tot deze goedaardige knobbels. Dat blijkt uit Brits onderzoek.

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New study links deodorants to breast lumps

An analysis of these so-called 'benign' breast lumps which has just been published in the Journal Of Applied Toxicology, shows they contain high levels of aluminium, which is unlikely to have entered the body through any dietary source.

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Claire Dimmer, of Breast Cancer UK, feels strongly that antiperspirants should not be used, and hasn’t used them herself for over 15 years.

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Tip: Remco

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"Onze" KWF is al jaren bezig om deze link af te doen als onzin en brengt met haar arrogantie veel vrouwen onnodig in gevaar. Denk zelf eens logisch na, stoffen die je op je huid smeert worden door het lichaam opgenomen dus ook metalen en chemicaliŽn. Of dit nu een deo is, een haarverf of een zonnebrandcreme is, je huid is het grootste orgaan. Kies voor produkten die je ook zou kunnen eten zoals kokosolie, amandelolie, zout, olijfolie etc etc. Wordt niet het volgende borstkankerslachtoffer. Baarmoederhalskanker risico's vallen in het niet bij de kans op borstkanker.

Ron


Hormonen en borstkanker

Patrik Vankrunkelsven is nog steeds actief als wetenschapper. Recent publiceerde hij in een internationaal wetenschappelijk tijdschrift (Breast Cancer Research and Treatment) als eerste auteur een artikel dat aantoont dat er een verband bestaat tussen het gebruik van hormonen en borstkanker. Jaren geleden al verwittigde hij voor het te grote gebruik van hormonen. Het goede nieuws is dat door de daling van het gebruik van hormonen, er ook een daling van het aantal borstkankers waar te nemen is. Wil dit zeggen dat men nooit hormonen mag nemen? Neen, als vrouwen in de menopauze echt veel klachten hebben, zoals vapeurs, is het verantwoord om deze klachten te behandelen met de laagst mogelijke dosis aan hormonen en gedurende een beperkte periode, liefst niet langer dan twee jaar. Artikel in het internationaal wetenschappelijk tijdschrift 'Breast Cancer Research and Treatment':

Reduction in hormone replacement therapy use and declining breast cancer incidence in the Belgian province of Limburg.

Patrik Vankrunkelsven ? Eliane Kellen ? DaniŽl Lousbergh ? Edith Cloes ? Lode Op de Beeck ? Christel Faes ? Liesbeth Bruckers ? Raf Mertens ?Jan W. Coebergh ? Flora E. Van Leeuwen ? Frank Buntinx

Abstract
Breast cancer is the most common femalecancer in Europe, but its incidence and mortality are rapidlychanging across Europe. The early termination of thewomen’s health initiative (WHI) trial, after the detection ofan increased breast cancer risk in hormone replacementtherapy (HRT) users, was followed by strong declines ofHRT use worldwide. We investigated whether the reductionof HRT sales affected breast cancer incidence in theBelgian province Limburg. All women registered in theLimburg Cancer Registry with a diagnosis of invasivebreast cancer diagnosed between 1/1/1996 and 31/12/2005were included in the study. Data on the use of HRT in thepopulation were obtained from the vendors and the socialsecurity system. For age-standardization using the directmethod, the European standard population was taken. In2003 and 2004, the breast cancer incidence rate decreasedsignificantly as compared to 2002 for women aged between50 and 69 years. This sudden drop in the incidence intercepteda markedly increasing trend until 2002, but wasfollowed again by an increase in 2005. Between 2002 and2006, the sales of HRT (about 75% to women aged 50–69 years) were reduced by 41%. Breast cancer incidencewas maximally related to HRT use in the previous year(R2 = 77%). The decrease of breast cancer incidence in theBelgian province of Limburg may largely be related to thefall of HRT use following the early termination of the WHItrial. This suggests that HRT stimulates the growth of preexisting,clinically latent tumours that may not otherwisebecome clinically apparent.

P. Vankrunkelsven (&) _ E. Kellen _ F. Buntinx Department of General Practice, Katholieke Universiteit Leuven, Leuven, Belgiume-mail: patrik@vankrunkelsven.beDit e-mail adres is beschermd door spambots, u heeft Javascript nodig om dit onderdeel te kunnen bekijken

D. Lousbergh _ E. Cloes Comprehensive Cancer Institute Limburg, Universiteit Hasselt, Hasselt, Belgium. L. Op de Beeck Department of Pathology, Mania hospital, Overpelt, Hasselt, Belgium
C. Faes _ L. Bruckers Interuniversity Institute for Biostatistics and Statistical Bioinformatics, Universiteit Hasselt, Hasselt, Belgium. R. Mertens Intermutalistisch Agentschap, Brussel, Belgium. J. W. Coebergh Comprehensive Cancer Center South, Erasmus University, Rotterdam, The Netherlands. F. E. Van Leeuwen Netherlands Cancer Institute, Amsterdam, The Netherlands

Breast Cancer Res Treat - DOI 10.1007/s10549-009-0346-9

Bron: www.vankrunkelsven.be


Stof in plastic (BPA) veroorzaakt borstkanker bij ratten

Low levels of BPA raise breast cancer risk in rat offspring

For the first time, scientists have shown that low levels of bisphenol A, even below levels considered safe by the EPA, increase breast cancer risk in rats exposed through their mother?s breast milk. A first of its kind study shows that low dose exposure to bisphenol A (BPA) during lactation increases the chance of breast cancer in rats. Early developmental exposures can have long lasting and adverse health effects. This is the first study to show that a mother rat’s exposure to BPA during lactation increases her daughter’s chances of breast tumors. Rats were used in this study because of the similarity in mammary (breast) gland development with that of humans. If this study could be extended to humans, it suggests that current safety standards fail to adequately protect the public. Current standards -- which are being reevaluated -- do not take into account recent findings that pertain to health effects from very low level exposures of BPA and related endocrine disruptors. Bisphenol A, or BPA, is a widely-used compound found in polycarbonate plastics and resins that line food and drink containers. Plastic baby bottles, teething toys and cans that contain formula can have BPA.

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Deze stof zit met name in plastic (baby) flesjes en speelgoed voor de tanden en komt met name vrij als je het plastic opwarmt. Kies dus voor veilige glazen flesjes.


Why Mammography is NOT an Effective Breast Cancer Screen

In the first part of the in-depth article linked below, Beyond Mammography, Dr. Len Saputo explores the latest findings on the effectiveness and shortcomings of various detection methods used by the mainstream medical community, including mammography, clinical breast exams, ultrasound, and to a lesser extent, magnetic resonance imaging (MRIs) and PET scans.

Download Ebook


BPA blokkeert effect borstkanker chemotherpie

Widespread human exposure to the chemical bisphenol A (BPA) has resulted from its use in a diverse array of consumer products. Research on the potential health effects of BPA has focused on the chemical’s ability to mimic or block natural estrogen. In animal studies, prenatal exposure to BPA increased susceptibility to mammary cancer in adulthood. However, studies of adult animals and cell cultures have had mixed results, and even less certain is how BPA might influence established breast cancer and its treatment. A new cell culture study is the first to show that BPA, at concentrations comparable to those found in the general population, reduces the efficacy of chemotherapy drugs in breast cancer cells, apparently by altering expression of proteins involved in apoptosis, or programmed cell death

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De grote borstkankerverdwijntruc !

Er zijn vermoedelijk borsttumoren die vanzelf weer verdwijnen, stellen onderzoekers van het Noorse gezondheidsinstituut in Oslo.

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Ik heb bij dit bericht een paar keer met mijn ogen geknipperd. Zoals ik lees hebben de mensen die minder mammogrammen lieten maken dus minder borstkanker. Dan denk ik, komt het doordat:

  • A - de extra straling juist kanker kan veroorzaken
  • B - veel borstkankergevallen helemaal geen kanker zijn
  • C - de Ryke Hamer theorie klopt, dat het conflict dat de basis is van borstkanker opgelost is

Verder blijkt uit een eerdere analyse van het Cochrane instituut dat voor iedere vrouw die je redt er 10 onnodig in gevaar worden gebracht.

Het wordt nog triester als je weet dat er gewoon alternatieven zijn voor mammografie......

Ron


Alternatief voor mammografie zonder de stralingsrisico's !

The world's first radar breast imaging system developed at Bristol University that could revolutionise the way women are scanned for breast cancer, is being trialled at North Bristol NHS Trust (NBT). Professor Alan Preece and Dr Ian Craddock from the University of Bristol have been working for a number of years to develop a breast-imaging device which uses radio waves and therefore has no radiation risk unlike conventional mammograms. The team began developing and researching a prototype around five years ago and have received funding from organisations including the Engineering and Physical Sciences Research Council (EPSRC), the trustees of the United Bristol Hospitals and the University of Bristol spin-out company, Micrima Ltd. Dr Ian Craddock from the University's Department of Electrical and Electronic Engineering, said: "This new imaging technique works by transmitting radio waves of a very low energy and detecting reflected signals, it then uses these signals to make a 3D image of the breast. This is basically the same as any radar system, such as the radars used for air traffic control at our airports."

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Lorraine Day's strijd tegen borstkanker mbv natuurlijke middelen

Beste Ron

Ik ben een trouwe lezer van je website, en met veel plezier lees ik de interessante zaken die je aan de orde stelt.  Je vroeg om nieuwe artikelen en links over kanker, en deze wil ik je sturen. Het gaat om een Amerikaanse arts, Lorraine Day, die helemaal hersteld is van borstkanker door natuurlijke middelen. Zij weet als geen ander (omdat zij zelf arts is) hoe belastend en desastreus de "normale" medicijnen zoals chemotherapie en bestraling zijn. Zij wilde deze dus niet gebruiken. Hoe zij genezen is vertelt zij in deze film! Ik vond de film een eye-opener.

Veel leesplezier!

Bekijk de site

Tip: Titia van der Kloet

 

Hier nog een mooie video over de aanpak van kanker:


Borstkanker en cosmetica

Een overzicht van ingrediŽnten in cosmetica die kankerverwekkend en hormoonverstorend zijn en dus de kans op borstkanker aanjagen. Je huid is je grootste orgaan, wat je erop smeert wordt gemakkelijk door het lichaam opgenomen. Mooie slogan: "Je bent een rund als je met cosmetica stunt"

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Ontstekingen, gebit en borstkanker

Ik zag ooit een thermografisch filmpje waarbij de maker uitlegde dat een ontsteking van een kies (bijvoorbeeld wortelpunten) kon doorslaan naar borstweefsel/borstklieren en daar mogelijk kanker kon bevorderen rondom het aangetaste weefsel.

In dat verband valt dit wel weer op zijn plaats:

Ontstekingsremmers verlagen de kans op borstkanker

http://news.bbc.co.uk/2/hi/health/7658472.stm

Alternatieve ontstekingsremmers zijn:

Omega 3 vetzuren !!!!!! (vette vis, walnoten, lijnzaad, algenolie)

Vitamine C

Olijfolie (koude persing)

Geelwortel (Curcuma)

En als je weet dat steeds meer onderzoekers ontstekingen zien als de echte oorzaak van depressies, kanker en hart- en vaatziekten doe dan je voordeel met deze informatie. En nog iets, teveel omega 6, dus linolzuur (zonnebloemolie, slaolie etc) en rood vlees (met name varkensvlees) jagen juist ontstekingen aan en kunnen zelfs de opname van omega 3 blokkeren.


Faktoren die je kans op borstkanker verhogen:

- Vroege menstruatie (voor 12 jaar)
- Geen kinderen krijgen
- Kinderen nemen na de leeftijd van 30 jaar
- Familiegeschiedenis met borstkanker (genetisch)
- Bestralingen in het borst gedeelte (dus ook mammografie!)
- HormoontherapiŽn (HRT) na 5 jaar of langer
- Overgewicht, vetcellen slaan oestrogeen op

Bron: American Cancer Society


Borstkanker en borstsamenstelling

Door de samenstelling van de borst anders te gaan bestuderen, zou meer informatie kunnen worden verkregen over de kans op het ontstaan van borstkanker en mogelijkheden om die kans te verkleinen. Gerco Haars komt tot die conclusie in zijn proefschrift. Vrouwen tussen de 50 en 75 jaar kunnen in Nederland elke twee jaar een borstfoto (mammogram) laten maken. In hoofdzaak worden die foto’s beoordeeld op het al dan niet aanwezig zijn van een mogelijke tumor. Op het mammogram zijn echter ook de hoeveelheid klierweefsel en vetweefsel te meten. Tot nu toe werd vooral de verhouding tussen die twee weefsels uitgerekend en onderzocht. Het is daardoor al lang bekend dat het hebben van een hoog percentage klierweefsel in de borst een aanwijzing is voor een hogere kans op het ontstaan van borstkanker. Het blijkt nu dat de hoeveelheid vet in de borst ook een rol zou kunnen spelen. Daarom zou het beter kunnen zijn om de hoeveelheid klierweefsel en vetweefsel apart te onderzoeken, in plaats van hun verhouding. Als het verband tussen vet en borstkanker kan worden bevestigt, biedt het nieuwe mogelijkheden voor verder onderzoek naar het ontstaan van borstkanker, maar ook meer mogelijkheden voor preventie omdat de hoeveelheid vet makkelijker is te beÔnvloeden dan de hoeveelheid klierweefsel. Gerco Haars promoveerde op 9 september aan het UMC Utrecht.


Vroegtijdige detectie zonder straling - Thermography

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Het gebruik van Digital Infrared Imaging (DII) is gebaseerd op het principe dat metabolische activiteit en bloedcirculatie in zowel pre-kanker weefsel en het gebied rondom borstkanker in ontwikkeling bijna altijd hoger is dan in gewoon borstweefsel. Vanwege een continu toenemende behoefte aan voedingstoffen, kankercellen verhogen de circulatie in hun cellen door bestaande aders open te houden, inactieve aders te openen en nieuwe te creŽren (neoangiogenesis). Dit proces leidt regelmatig tot een verhoging van de temperatuur op lokale plekken op de borst. DII gebruikt ultragevoelige medische infrarood camera's en geavanceerde computers om zeer duidelijke beelden van deze temperatuurvariabelen op te sporen, analyseren en produceren. Vanwege de hoge gevoeligheid van DII, kunnen deze temperatuurvariabelen ťťn van de meest vroege tekenen van borstkanker en/ of een pre-kanker staat van de borst, zijn.



http://www.breastthermography.com/
http://www.thermologyonline.org/


Make-up: Borstkanker en de oestrogeen link

Oestrogeen chemicaliŽn in cosmetica. Wat je moet weten, van Cornell Universiteit. Wat je meteen al kan doen: Lees de labels aandachtig. IngrediŽnten zijn genoteerd in aflopende orde gebaseerd op gewicht op alle persoonlijke verzorgingsproducten. Leer en onthoud de namen van chemische oestrogenen zoals Paraben, Placenta extracten, Benzophenonen. Maak keuzes. Overweeg om producten te gebruiken die geen chemische oestrogenen bevatten.

http://envirocancer.cornell.edu/research/endocrine/videos/makeup.cfm


William Campbell Douglass over Soja en Oestrogeen

Auteur en dokter William Campbell Douglass bespreekt de problemen die gelinkt zijn met soja vanwege de eigenschap om het vrouwelijke hormoon, oestrogeen, na te bootsen.

http://www.youtube.com/v/BMkZ6gtR2fo


Zelf borsten onderzoeken heeft geen nut

Het onderzoek, dat werd uitgevoerd door de Deense vestiging van het Britse Cochrane instituut, bevestigt wat eigenlijk al langer duidelijk was: zelfonderzoek van de borsten leidt op lange termijn niet tot minder sterfte door borstkanker. Zelfcontrole heeft zelfs nadelen.

http://www.nieuwsblad.be/Article/Detail.aspx?articleid=GS11UG7GF


Borstkankeronderzoek - de risico's versus de voordelen

Het Cochrane instituut is een onafhankelijke wetenschappelijke organisatie die kritisch kijkt naar medische studies. Uit een analyse van 7 studies gedaan onder 500.000 vrouwen blijkt het volgende:

Van iedere 2000 vrouwen die 10 jaar lang worden gecontroleeerd wordt er van ťťn vrouw het leven verlengd maar 10 gezonde vrouwen worden onnodig behandeld voor borstkanker met alle risico's van dien.

De vraag is nu dus of het screenen meer goed doet dan kwaad....Vrouwen horen op de hoogte te zijn van de mogelijke risico's en voordelen van onderzoek volgens de onderzoekers.

Conclusies van de auteur

Screening wekt de indruk dat het borstkanker sterftecijfers verlaagd. Gebaseerd op alle testen, wordt het percentage verlaagd met 20%, maar aangezien het effect lager is in de hoogste kwaliteitstesten, is 15% een meer realistischer schatting. Gebaseerd op het risico niveau van de vrouwen in deze testen, was de absolute risico verlaging 0,05%. Screening leidt ook tot onnodige diagnoses en onnodige behandelingen, met gemiddeld 30% toename, of een absolute risico toename van 0,05%. Dit betekent dat voor elke 2000 vrouwen die gedurende 10 jaar gescreend worden, er ťťn leven verlengt zal worden. Daar tegenover staat dat 10 gezonde vrouwen, die anders geen diagnose zouden krijgen als er geen screening plaats had gevonden, nu gediagnosticeerd worden met borstkanker en daarom onnodig behandeld zullen worden. Het is daarom nog niet duidelijk of screening meer goed dan kwaad doet. Vrouwen die opgeroepen worden voor screening moeten volledig geÔnformeerd worden over de voor- en nadelen van screening.  

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De Cochrane Collaboration is een internationale, non-profit en onafhankelijke organisatie die zich toewijd op het verschaffen van up to date en accurate informatie over de effecten van de medische zorg die wereldwijd beschikbaar is. Het produceert en ontleedt systematisch de verslagen van medische interventies en stimuleert de zoektocht naar bewijs zoals klinische testen en andere studies over interventies. De Cochrane Collaboration is gesticht in 1993 en is vernoemd naar de Britse epidemioloog, Archie Cochrane.

http://www.cochrane.dk/


Bewijs voor relatie acrylamide en borstkanker !

Ik noem al 2.5 jaar als een roepende in de woestijn de gevaren van verhitting van granen en aardappels boven de 120 graden maar nu is er dan het eerste bewijs voor een relatie tussen deze stof en borstkanker. Deze stof zit met name in ontbijtkoek, pepernoten, bruin gebakken chips, bruin gebakken patat etc etc.

Meer info op:
http://www.fonteine.com/acrylamide.html

 

Acrylamide in voedsel verhoogt mogelijk het risico op borstkanker

Acrylamide is a chemical formed when frying, roasting, grilling or baking carbohydrate-rich foods Acrylamide is een chemische stof die gevormd wordt wanneer men koolhydraatrijke voedingsmiddelen bakt, roostert, grilt of frituurt boven een temperatuur van 120įC. Acrylamide wordt daarom dan ook gevonden in een flink aantal voedingswaren zoals brood, chips, friet en koffie. Roken genereert ook aanzienlijke hoeveelheden acrylamide.

"Dierproeven hebben aangetoond dat acrylamide kankerverwekkend is, maar tot voorheen zijn er geen studies geweest die een link aantoonden tussen acrylamide in voeding en kanker bij mensen. Onze studie is de eerste epidemiologische studie die biologische beginpunten gebruikt om blootstelling aan acrylamide te meten. En het is ook de eerste die een positieve relatie tussen acrylamide en borstkanker meldt," zegt Henrik Frandsen, senior wetenschapper bij de National Food Institute, Technische Universiteit van Denemarken.

http://www.alphagalileo.org/index.cfm?fuseaction=readrelease&
releaseid=526253&ez_search=1


Opnieuw link borstkanker en het progesteron hormoon

Dus de pil en menopauze medicatie !

Een link met borstkanker

Onderzoekers tonen link aan tussen hormoongroei en tumoren.
Veel vrouwen boven de 40 hebben kleine tumoren in hun borsten - meestal zonder dat ze daar vanaf weten. Deze tumoren groeien normaal gesproken tot 1 millimeter in omvang en stoppen daarna met zich verder ontwikkelen omdat ze te weinig voedingsstoffen krijgen. Dus hoe en waarom ontwikkelen andere tumoren zich wel tot kanker? Deze vraag is de stuwende kracht achter het werk van de biomedische wetenschappelijke onderzoeker Salman Hyder. In het nummer van 15 oktober van Cancer Research, Hyder en collega's publiceerden hun bevindingen over progesteron, een hormoon dat voorkomt in anticonceptie en middelen voor de menopauze. Hun onderzoek toont aan dat progesteron actief betrokken is bij de verdere ontwikkeling van menselijke borstkanker cellen bij een dierlijk model. Tot voorkort waren zulke bevindingen beperkt tot dierlijke cellen.

Tumoren stimuleren
Nieuw weefsel dat zich wil ontwikkelen heeft de vorming van nieuwe bloedvaten nodig - een proces dat angiogenesis genoemd wordt. Tumorcellen kunnen signalen generen, in de vorm van 'groeifactoren' die hen toelaat nieuwe bloedvaten van nabijgelegen weefsel over te nemen. Hyder bestudeert het mechanisme waardoor deze signalen zich genereren, daarbij focust hij zich meer specifiek op de vasculaire edotheliale groei factor (VEGF). Hyder - de Thelma P. Zalk Missouri Professor van Tumor Angiogenisis en een onderzoeker aan de Dalton Cardiovasculair Onderzoek Centrum - werkt samen met collega Yayun Liang en andere medewerkers in Mizzou en de Universiteit van Texas Southwestern. De groep heeft aangetoond hoe progesteron en VEGF op elkaar reageren in bepaalde tumor cellen die een mutantversie van een proteÔne genaamd p53 bevatten. Hyder zegt dat p53 eigenlijk tumoren in normale gevallen onderdrukt. Echter, sommige vrouwen hebben een mutant p53 dat niet op diezelfde manier werkt. Bij deze vrouwen, "begint" progesteron VEGF uitbreiding. Anders gezegd, betekent dit dat progesteron een toename in nieuwe bloedvaten kan bevorderen, welke op hun beurt, de ontwikkeling van een tumor voeden.

Hormoon therapieŽn en het dilemma.
Salman Hyder en collega's hebben een link aangetoond tussen progesteron en toename van borstkanker in menselijke cellen. Vrouwen krijgen progesteron binnen via anticonceptie en andere medische situaties. Synthetische progesteron, of progestin, wordt ook wel gegeven in combinatie met oestrogeen als een hormoonvervangende therapie (HRT) om opvliegers, depressies en andere symptomen van de menopauze te verminderen. Met HRT voorkomt het progestin zelfs de tumoren die kunnen ontwikkelen wanneer oestrogeen de baarmoeder stimuleert. Echter, vele medische proeven, waaronder de Million Women Study en een uitgebreide National Studies of Health, ook wel bekend als de Women's Health Initiative (WHI), tonen aan dat wanneer progestin over een langere periode wordt ingenomen, dit het risico op borstkanker met ongeveer 26 procent verhoogt. Daarmee ontstaat er een dilemma voor vrouwen tijdens de menopauze - of een HRT behandeling met progestin en een verhoogd risico op borstkanker, of op zoek naar alternatieve hormoontherapie zonder progestin en verhoog het risico op baarmoederkanker. Hyder zegt dat dit dilemma een grootschalige discussie op gang gezet heeft. Hij adviseert vrouwen om met hun dokters te overleggen en daarna een goed geÔnformeerde beslissing te nemen over het wel of niet innemen van HRT. Dokters zullen de familiegeschiedenis, leefwijze en andere factoren evalueren en meenemen in de overweging.

"Er is weinig twijfel meer dat progestins de aanmaak van nieuwe bloedvaten kunnen verhogen, wat daarmee tot tumor ontwikkeling kan leiden," zegt Hyder. "Als er een aanleg voor borstkanker in de familie is, dan is het zeer aan te raden voor vrouwen om medicamenten met progestins te vermijden." Nieuwe ontwikkelingen en toekomstige behandelingen die een link aantonen tussen progesteron en borstkanker in menselijke cellen is een duidelijke stap voorwaarts en het heeft geleid tot verder onderzoek. Hyder en zijn collega's bestuderen manieren om tumoren uit te roeien door de VEGF te onderdrukken en bepaalde bloedvaten te doden die tumoren in ontwikkeling voeden. Natuurlijke, niet-muterende p53 treedt op als een tumoronderdrukker en corrigeert fouten of roeit mogelijke kankercellen uit wanneer die te overheersend worden. Zulke middelen scheppen niet alleen mogelijkheden in de behandeling van borstkanker tumoren, maar ook bij andere vormen van kanker. Hyder en zijn collega's discussiŽren deze mogelijkheden in Cancer Research. "Wanneer we veilige anti-hormonen of anti-angiogenesis kunnen vinden, dan zouden we wellicht de groei van tumoren kunnen voorkomen of stopzetten," aldus Hyder.

Bron: http://www.missouri.edu/

Even voor alle duidelijkheid: De pil bevat zowel het vrouwelijke hormoon oestrogeen als  het hormoon progesteron !


Bij borstkanker minder chemo nodig

Duizenden borstkankerpatiŽnten krijgen chemo terwijl ze dat bespaard zou kunnen blijven. Dit blijkt uit Amerikaans onderzoek.

http://www.nu.nl/news/1355708/151/rss/Bij_borstkanker_minder_chemo_nodig.html


CafeÔne, knobbelige borsten en mammografie

Producten met cafeÔne (o.a. koffie, thee, cola, energiedranken) zorgen voor gevoelige en knobbelige borsten. Daarom wordt aangeraden 1 week voor de mammografie deze producten niet te consumeren, om onnodige pijn te voorkomen. Vrouwen die nog menstrueren kunnen het best de mammografie in de eerste helft van de cyclus laten verrichten, aldus Christian Albring van het beroepsverband van vrouwenartsen. Duitsland: bericht van ARD -text 2 november 2007

xxx


Mammogrammen verhogen kans op borstkanker met 250%

An International Agency for Research on Cancer study showed that chest X-rays may increase women's chances of developing breast cancer. The study involved 1,600 women with high-risk
BRCA1 and 2 gene mutations. "If confirmed in prospective studies, young women who are members of families known to have BRCA1 or BRCA2 mutations may wish to consider alternatives to X-ray, such as MRI," Lead researcher Dr. David Goldgar said....

http://www.newstarget.com/019477.html

Frank


Mammografie bij veertigers (40-49) zinloos volgens Canadese studie

A Canadian study has found that mammograms don't give women in their 40s a better chance of surviving breast cancer.

http://www.ctv.ca/servlet/ArticleNews/story/CTVNews/20020902/mammogram_study_020902/
http://nl.wikipedia.org/wiki/Mammogram


Breastcancer treatment fails most women

Researchers say common chemotherapy drugs too risky for many patients

What if an estimated 100,000 breast cancer patients got drugs that did nothing to combat their cancer, but put them at risk for heart failure and leukemia? That is the implication of new
research that was presented in private session at this week's meeting of the American Society of Clinical Oncology(ASCO) in Chicago.....

http://www.msnbc.msn.com/id/19048185/

Frank


50% breastcancers missed by mammograms

∑ MRI scans found to detect better than x-rays
∑ Charities say current screening still effective

Cancer screening programmes are failing to detect nearly half of the earliest cases of breast cancer according to research which suggests women's lives could be saved if all were offered hi-tech
MRI scans. The study in the Lancet medical journal found that x-ray based mammograms detect only 56% of early lesions in high risk women compared with 92% when magnetic resonance
imaging scans (MRI), more commonly used for brain scans, are used.....

http://www.guardian.co.uk/medicine/story/0%2C%2C2145922%2C00.html

Frank


Aspartame causes breastcancer

A new study on aspartame conducted by the Ramazzini Foundation reveals that aspartame causes a dose-dependent increase in cancers (lymphomas, leukemias and breast cancers) when consumed at levels approaching those consumed by humans in diet soft drinks.....

http://www.newstarget.com/021920.html

Frank


Borstkankerpreventie wereldwijd

Nadat ook ik in mijn omgeving werd geconfronteerd met "vermoedens van borstkanker", vond ik dat het wel erg dichtbij was gekomen. De moeder van een Italiaanse vriendin (jong!) overleed eraan; de vriendin met ook klachten staat onder strenge controle. Hetzelfde met een vriendin in Nederland...........Onderstaande link is het waard door ALLE VROUWEN gelezen te worden (...en natuurlijk de mannen niet te vergeten). En geef de link door aan je vriendinnen, want ieder kan te maken krijgen met borstkanker.

http://www.vitalworld.org/breast-cancer-prevention.htm

xxx


Rood vlees verdubbelt kans op borstkanker

Vrouwen die per dag 1.5 portie rood vlees eten hebben ten opzichte van vrouwen die drie keer per week rood vlees eten een dubbele kans op borstkanker volgens een nieuwe analyse van de The Nurses’ Health Study door onderzoekers van de Harvard Medical School.

http://msnbc.msn.com/id/15702642/


MSNBC special over rood vlees en verhoogde kans op borstkanker

In deze uitzending een gesprek met de onderzoekster die deze conclusie naar buiten bracht

http://www.msnbc.msn.com/id/15702642/

 


74% meer kans op borstkanker door gegrild vlees

Dr Kala Visvanathan ( Johns Hopkins University) deed onderzoek naar eetpatronen van ruim 300 vrouwen met borstkanker en 300 vrouwen zonder borstkanker. Zij ontdekte dat vrouwen die 2 keer maand gegrild vlees (boven vlammen) aten 74% meer kans op borstkanker hadden. Door de sterke verhitting ontstaan namelijk meer kankerverwekkende chemicaliŽn, de zogenaamde heterocyclic amines.

http://news.ninemsn.com.au/article.aspx?id=163462

Vorige jaar kwam er al een studie naar buiten met een relatie tussen barbecue vlees en prostaatkanker

http://www.rtl.nl/(/actueel/rtlnieuws/)/components/actueel/
rtlnieuws/2006/04_april/03/

http://www.msnbc.msn.com/id/12133894/


Met Arimidex langer borstkankervrij dan met Tamoxifen 

Volgens een meta-analyse van 3 belangrijke studies door Professor Walter Jonat van de Universiteit in Kiel, Duitsland kunnen vrouwen met borstkanker langer kankervrij blijven door Tamoxifen te vervangen
door Arimidex.

http://www.perssupport.nl/Home/Persberichten/Actueel?itemId=87059 



Oestrogenen en borstkanker

Over de afgelopen jaren is er een toename te zien in het aantal gevallen van borstkanker in de westerse wereld. Tegenwoordig krijgt gemiddeld 1 op de 8 vrouwen borstkanker. In Nederland komt dit neer op ongeveer 10 000 vrouwen per jaar, van wie er ongeveer 3 500 sterven aan de gevolgen ervan. Er zijn verschillende genetische risicofactoren bekend, zoals het borstkankergen BRCA, maar in het overgrote deel van de borstkanker gevallen is de oorzaak niet zo duidelijk aan te wijzen. Er is wel een aantal factoren die het risico op borstkanker kunnen vergroten. Dit zijn bijvoorbeeld op jonge leeftijd de eerste menstruatie krijgen, op late leeftijd in de menopauze komen, geen kinderen krijgen of op late leeftijd een eerste kind krijgen, al eerder borstkanker hebben gehad en ook verschillende levensstijlfactoren kunnen een rol spelen. Al deze factoren hebben invloed op de hoeveelheid oestrogenen waar een vrouw gedurende haar leven aan wordt blootgesteld.

http://igitur-archive.library.uu.nl/2005-0128-112727/sam.pdf


TV - Borstkanker - ook mannen krijgen het !

Het is borstkankermaand. Denk je aan borstkanker, dan denkt iedereen automatisch aan vrouwen. Maar ook mannen kunnen borstkanker krijgen. Het is dan ook vrij zeldzaam, maar dat neemt niet weg dat er meer voorlichting moet zijn voor mannen die het overkomt. De informatie is nu nog veel te veel op vrouwen gericht, vindt borstkankerpatient Simon Luites.

http://rtl.nl/system/video


Nog niet zwanger geweest ? Dan meer kans op borstkanker !

Waarom hebben vrouwen zonder kinderen meer kans op borstkanker? Simpel omdat het weefsel in de borst nog niet de veranderingen heeft doorgemaakt die normaal tijdens een zwangerschap plaatsvinden. Het weefsel is dan ook vatbaarder voor kankerverwekkende stoffen. Zo is intussen ook bekend dat het geven van borstvoeding juist de kans op borstkanker weer verkleint. En doe je dit minimaal 6 maanden dan ook verbetering van de mentale ontwikkelingen/gedrag van je kind op latere leeftijd bleek afgelopen week uit
een 16 jarige studie in AustraliŽ, minder depressies, minder asociaal en agressief gedrag.....

Dus je kunt wel nagaan wat de risico's zijn als je rookt voor je eerste zwangerschap......

http://www.mayoclinicproceedings.com/inside.asp?AID=4181&UID

Zo is intussen ook bekend dat het geven van borstvoeding juist de kans op borstkanker weer verkleint. En doe je dit minimaal 6 maanden dan ook verbetering van de mentale ontwikkelingen/gedrag van je kind op latere leeftijd bleek afgelopen week uit een 16 jarige studie in AustraliŽ, minder depressies, minder asociaal en agressief gedrag.....

http://www.abc.net.au/news/newsitems/200610/s1775389.htm


44% meer kans op borstkanker voor de menopauze door de pil

Uit een nieuwe meta-analyse van 34 studies in de oktober uitgave van de bekende Mayo Clinic Proceedings mbt de kans op borstkanker door orale voorbehoedsmiddelen (de pil) blijkt opnieuw dat vrouwen een verhoogde kans op borstkanker hebben, met name de vrouwen die al voor het eerste kind de pil slikten hebben meer kans om borstkanker te krijgen voor de menopause. Het percentage is zelfs 44%

De wereldgezondheidsorganisatie zetten al in 2005 orale voorbehoedsmiddelen op de lijst van klasse 1 kankerverwekkende stoffen. De onderzoekers geloven dan ook dat artsen hun patiŽnten hierover moeten inlichten omdat de patiŽnt recht op deze informatie heeft.

http://www.eurekalert.org/pub_releases/2006-10/mc-oci103006.php

 

Oral Contraceptive Use and Breast Cancer Risk: Current Status

One might have thought that the issue of whether oral contraceptives (OCs) are associated with breast cancer risk would have been settled by now, given that these agents were introduced in the early 1960s and more than 60 case-control and 10 cohort studies, several meta-analyses,- a very large pooled analysis, and a major monograph have addressed this issue. On the basis of the accumulated data, the International Agency for Research on Cancer (IARC) classified oral estrogen-progestogen contraceptives as carcinogenic to humans (group 1 carcinogen) in 2005, which is a higher classification than the 1999 IARC evaluation.

http://www.mayoclinicproceedings.com/


Always a Bitter Pill, Now the Risk of Breast Cancer Makes Oral Contraceptives
Even Harder to Swallow

However, compelling data has emerged linking the Pill with the rapid increase of breast cancer in the US, with a potential of class action lawsuits that could eclipse those even of the tobacco industry. Evidence has been available for several decades linking oral contraceptives with breast cancer in certain lab animals. According to Chris Kahlenborn, MD, one of the nation’s leading researchers on the breast cancer/ Pill connection, the evidence of a link in humans is incontrovertible. His book summarizing his research and findings, BREAST CANCER: Its Link to Abortion and the Birth Control Pill, was published recently by One More Soul (www.OMS.com.)

http://www.marysremnant.org/Friends/DBK/BKBitterPill.html


Nuttige link:

http://www.orthoeurope.com/home.php?
page=view_ziektebeeld&ziektebeeld=37/Borstkanker


Borstcontrole - mammogram of breast specific gamma imaging ?

Het kan gebeuren dat je bent gecontroleerd mbv ultrasound of mammogram op borstkanker en dat je toch zelf een knobbeltje in de borst ontdekt. Er is nu nog een betere controle mogelijke met zogenaamde breast specific gamma imaging apparatuur die meer opspoort dan de oudere methodes.
http://www.komotv.com/news/4481626.html

Site vd fabrikant : http://www.dilon.com


Mammogrammen verlagen aantal doden door borstkanker maar vergroten overdiagnoses

Een nieuw onderzoek naar studies mbt mammogrammen laat een voor-
en nadeel zien:

  • 15% minder dodelijke slachtoffers door borstkanker
  • 30% meer kans op diagnose en behandeling van kanker die normaal geen bedreiging was geweest

http://www.cfah.org/hbns/getDocument.cfm?documentID=1373


Update 2006 - borstkanker en deo's

In 2004 beweerde een Engelse onderzoekster dat er een verband was tussen deodorants die aluminium bevatte en borstkanker. Door zowel de fabrikanten als KWF kankerbestrijding werd dit als een hoax afgedaan maar nu is er in 2006 weer een studie gepubliceerd waarin men waarschuwt voor metalen waaronder aluminium die door zich te binden aan oestrogeen receptoren de werking van deze hormonen kunnen nabootsen. En juist een verhoogde oestrogeen werking speelt een rol bij borstkanker. Deze studie noemt oa lood, kwik, nikkel, aluminium, kobalt, koper, nikkel, tin, cadmium (door het roken!!).

Potential link between aluminium salts in antiperspirants and breast cancer warrants further research

Chemicals that mimic the body’s natural hormone oestrogen are known to affect a woman’s risk of breast cancer. Evidence is mounting that the aluminium-based compound, which often makes up quarter of the volume of some antiperspirant agents, can break through the skin and that once in the body it could mimic oestrogen. A review just published in the Journal of Applied Toxicology calls for further research to evaluate the potential that this could increase the risk of getting breast cancer.

Over recent years, scientists have found that many compounds in the environment mimic or interfere with oestrogen. These compounds are normally complex molecules and are found in many plants, and used in materials like detergents, pesticides and plastics. Now scientists are realising that a variety of simple metal ions, including aluminium and cadmium can also bind to the body’s oestrogen-receptors and influence their action.

"Since oestrogen is known to be involved in the development and progression of human breast cancer, any components of the environment that have oestrogenic activity and which can enter the human breast could theoretically influence a woman’s risk of breast cancer," says author of the review Dr Philippa Darbre, who works in the School of Biological Sciences, at the University of Reading, UK.

Aluminium salts in antiperspirants are a major source of exposure to aluminium in humans. It is often sprayed into armpits, inadvertently concentrating exposure near to the breast. In addition, it is often applied immediately after shaving, when the skin is likely to be damaged and less able to keep the aluminium out. "It is reasonable to question whether this aluminium could then influence breast cancer," says Darbre.

Her concern is not confined to aluminium. Smoking tobacco introduces cadmium into the body, and research shows that it too can collect in breast tissue. There are indications that this accumulation of cadmium may also be linked to an increased risk of breast cancer, potentially showing one of the reasons why smoking could be linked to this disease.

"Each of these agents on their own may not have a powerful effect, but we need to see what happens when a number of them act together – it could be that this would have a significant effect on diseases like breast cancer," says Darbre.

Studie:
Darbre P D. Metalloestrogens: an emerging class of inorganic xenoestrogens with potential to add to the oestrogenic burden of the human breast. Journal of Applied Toxicology. 2006; DOI:10.1002/jat.1135

http://www.biosci.rdg.ac.uk/DrPhilippaDarbre.htm

http://www.extra.rdg.ac.uk/news/details.asp?ID=624

http://www3.interscience.wiley.com/cgi-bin/abstract/112438172/

http://noorderlicht.vpro.nl/afleveringen/15336420/

http://www.fonteine.com/borstkanker.html


Vitamine D speelt inderdaad rol bij borstkanker

Al eerder legden onderzoekers een relatie tussen Noord-Europese landen en borstkanker. Hoe noorderlijker je woont hoe minder zonlicht en hoe meer borstkanker. Door de zon maakt je huid vitamine D aan. Nu blijkt uit nieuwe bloedonderzoek bij vrouwen met borstkanker dat vrouwen in de laatste stages de laagste niveau's van Vitamine D hebben. Blijkbaar heeft deze vitamine een remmende werking op de vooruitgang vd ziekte. Krijg je te weinig zonlicht dan is het alternatief vette vis of levertraan eten.

http://www.guardian.co.uk/medicine/story/0,,1924059,00.html


Boerinnen hebben een drie keer zo hoge kans op borstkanker

Uit een recent Canadees onderzoek blijkt dat vrouwen die al hun leven lang op een boerderij werken de kans op borstkanker drie keer zo groot is dan bij andere vrouwen. De vrouwen die later een baan zochten in de nabijgelegen auto-industrie hadden zelfs een vier keer zo grote kans om borstkanker te krijgen.

Reden? De blootstelling aan de vele chemicaliŽn, met name de gebruikte pesticiden.

http://www.canada.com/topics/news/national/story.html


Videodagboek - borstkanker

Puck de Leeuw (48) is filmmaakster en in de bloei van haar carriŤre als ze terminale longkanker krijgt. Prognose: een jaar of minder. Puck is alleenstaand, maar om haar heen ontstaat een kring van familie, vrienden en buren die haar bijstaan in deze laatste fase van haar leven. Vanaf het moment dat ze ziek wordt houdt Puck een videodagboek bij. Deze documentaire laat zien wat er met Puck en haar omgeving gebeurt als de dood zich aankondigt.

http://player.omroep.nl/


Meer borstkanker bij nachtwerk
Volgens Amerikaanse onderzoekers zou nachtarbeid de kans op borstkanker met 60% verhogen. Dat is het resultaat van ťťn van de allereerste studies naar een eventueel verband tussen het kankerrisico en de blootstelling aan licht 's nachts. De studie werd uitgevoerd bij meer dan 1.600 vrouwen van wie de helft aan borstkanker leed. Bij die vrouwen werd nagegaan in welke mate ze de laatste 10 jaar voordat de diagnose werd gesteld, waren blootgesteld aan licht tijdens nachtarbeid. De resultaten tonen aan dat vrouwen die tijdens die periode van 10 jaar minstens eenmaal in nachtploegen hadden gewerkt, 60% meer kans lopen op borstkanker dan andere vrouwen. 

Het risico stijgt met het aantal uren nachtarbeid per week. Het is uiteraard nog voorbarig om richtlijnen uit te werken voor personen die 's nachts aan licht worden blootgesteld. Het zou echter blijken dat alles wat ons biologische ritme verstoort, een invloed kan hebben op de hormonen en die hebben dan weer een invloed op het kankerrisico. Een mogelijk mechanisme zou kunnen worden verklaard door melatonine, een hormoon dat een rol speelt in onze slaap-waakcyclus en waarvan de synthese wordt gestimuleerd door de duisternis en geremd door licht. Kunstlicht 's nachts zou dan ook de productie van melatonine kunnen afremmen, hetgeen de synthese van oestrogenen en dus het risico op borstkanker zou verhogen.  Die hypothese strookt met de resultaten van een andere studie die aantoont dat blinde vrouwen, die een constant melatoninegehalte hebben, minder kans lopen op borstkanker. [Bron] J. Nat. Cancer Institute, 20: 1557-1562, 2001


De trieste werkelijkheid - de arrogantie van de medische "goden"

In en in triest is nog steeds het gebrek aan samenwerking tussen de gevestigde orde en patiŽnten die zelf willen beslissen hoe hun kanker behandeld zal worden. Steeds meer mensen gaan op eigen houtje dingen ondernemen omdat hun specialist doof lijkt te zijn voor hun persoonlijke wensen. Hoog tijd dat de patiŽnt recht op meer inspraak krijgt over zijn eigen behandeling en niet is overgeleverd aan iemand die niet met je meedenkt. Of blijft het "Chemotherapie geslaagd maar patiŽnt helaas overleden" ?

Het verhaal van Julischka, een jonge moeder met twee zoontjes en een zeer agressieve vorm van borstkanker:

Ik ben Julischka, Z-verpleegkundige, 38 jaar oud, getrouwd en moeder van twee zoontjes van zes en ťťn jaar oud. Bij mij werd op 3 januari 2006 een kwaadaardige borsttumor ontdekt. In deze open brief wil ik mijn ervaringen die ik nadien heb opgedaan vertellen en dat ik een behandelwens heb die de artsen tot nu toe niet honoreren. Hierbij roep ik alle artsen op om kennis te nemen van mijn behandelwens en ik hoop dat er artsen zijn die mij op die wijze willen behandelen. 

De tumor die ik heb is zo agressief dat de kans groot is dat ik aan deze ziekte zal komen te overlijden, aldus de specialist. In mijn okselklieren werden ook al tumorcellen gevonden. De tumorcellen kunnen dus ook al in andere delen van mijn lichaam verspreid zijn. Daarom kan de tumor niet plaatselijk worden behandeld maar is een overal werkzame  chemotherapie nodig. De specialist stelde mij voor om de behandeling te beginnen met een chemotherapie die als bijwerking heeft dat het middel de hartspier kan beschadigen. Het is in Nederland gebruikelijk om met dit middel de behandeling tegen mijn vorm van borstkanker te beginnen. Daarna kan ik behandeld worden met verscheidene andere geneesmiddelen die de tumorcellen kunnen bestrijden en met bestraling.

Het hele verhaal staat op: http://home.wanadoo.nl/jcmonkenhout/


Inflammatory Breast Cancer

Inflammatory Breast Cancer - de gevaarlijkste en onbekendste vorm van borstkanker

http://www.youtube.com/watch?v=3s9_UrVtc6c


Zicht op genezing uitgezaaide borstkanker

Onderzoekers van het academisch ziekenhuis Maastricht (azM) hebben een nieuwe behandeling ontwikkeld die zicht biedt op genezing van uitgezaaide borstkanker zonder dat een operatie nodig is. In een muismodel lukte het de onderzoekers de kankercellen 'op te ruimen' met donorstamcellen. Via een stamceltransplantatie werd het immuunsysteem van de muizen als het ware vervangen door het immuunsysteem van een donor. Het donorafweersysteem herkent de kankercellen als slechte cellen en ruimt ze op. Uitgezaaide borstkanker kan niet worden geopereerd en bestraling en chemokuren werken meestal maar tijdelijk. Door de behandeling steeg de overlevingskans van de muizen met 75 procent.

http://www.azm.nl/algemene+informatie/actueel/pers/
stamcellen+vs+borstkanker


Lijnzaad remt borstkanker

Lijnzaad in het dieet heeft de potentie om tumor groei te verkleinen in patiŽnten met borstkanker

http://clincancerres.aacrjournals.org/cgi/content/full/11/10/3828


Curcumin (stof in kurkuma/kerrie) remt borstkankercellen

Curcumin exerts multiple suppressive effects on human breast carcinoma cells.

Shao ZM, Shen ZZ, Liu CH, Sartippour MR, Go VL, Heber D, Nguyen M.          Int J Cancer. 2002 Mar 10;98(2):234-40.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=
Retrieve&dopt=AbstractPlus&list_uids=11857414&query_hl=
3&itool=pubmed_docsum


Overgewicht vergroot kans op borstkanker

De "American Cancer Society" presenteerde onlangs bewijs dat een verband legt tussen overgewicht op latere leeftijd en borstkanker. De studie op 44,000 vrouwen toonde aan dat hoe meer vrouwen in gewicht toenamen hoe groter de kans op allerlei types/gradaties van borstkanker. Borstkanker wordt in verband gebracht met verhoogde niveau's oestrogenen. Vetweefsel produceert extra oestrogenen waardoor het risico op borstkanker toeneemt.

Onderzoekers van Harvard kwamen al een onderzoek naar buiten dat vrouwen die hormoontherapie hadden gevolgd ook verhoogde kans op borstkanker hadden, dit waren dan wel vrouwen die vaak combinaties gebruikten van oestrogeen en progestine en over een langere periode (15-20 jaar). De vrouwen die het al 20 jaar gebruikten hadden zelfs een 48% hogere kans op borstkanker.

Vrouwen die hormoontherapie gebruiken om menopause symptomen te onderdrukken hebben bij korte termijn gebruik geen vergrote kans op borstkanker maar moeten wel beseffen dat oestrogeen wel andere risico's vergroot zoals hartaanval en bloedklontering.

http://www.prweb.com/releases/2006/6/prweb399897.htm
http://www.cancer.org/docroot/NWS/content/NWS_1_1x_
Long-Term_Estrogen_Use_Linked_to_Breast_Cancer_Risk.asp


Gel voor vrouwen die borstkanker operatie en bestraling
moeten ondergaan

Vrouwen die een operatie moeten ondergaan vanwege borstkanker gevolgd door bestralingstherapie krijgen vaak te maken met vervormingen van de borsten waarvoor dan weer een extra hersteloperatie nodig is. Onderzoekers van het McGowan Institute for Regenerative Medicine, in samenwerking met bioengineers van de Carnegie Mellon Universiteit hebben nu echter een polymeer gel ontwikkeld die zowel geleidelijk chemotherapie vrijgeeft en die tevens vulmiddel in de borst kan worden gebruikt.

http://newsbureau.upmc.com/UPCI/ChemotherapyGel.htm


Risicoverhogend effect hormonale substitutie

In grootschalige onderzoeken in de VS werd een toename van de kans op borstkanker gevonden bij vrouwen die postmenopauzaal langer dan vijf jaar oestrogeensubstitutie gebruikten. De kans op het krijgen van borstkanker was bij deze vrouwen 30-40% groter dan voor vrouwen die geen hormonen hadden gebruikt (Colditz et al., 1995; Collaborative Group on Hormonal Factors in Breast Cancer, 1997). Tumoren die onder invloed van hormonale substitutie ontstaan, zijn vaak van het lobulaire type (Chen et al., 2002a).
Een grote Britse studie bevestigt de eerder gevonden toename van het risico van borstkanker bij het gebruik van producten met alleen een oestrogeen (toename 20-40%). Daarenboven toont de studie aan dat de toename van het risico veel groter is (90-210%) bij het gebruik van een combinatietherapie van oestrogeen en een progestageen (Million Women Study, 2003).

De toename van de kans op borstkanker is afhankelijk van de duur van de behandeling. De kans neemt af vanaf het moment dat HST wordt gestaakt. Vijf jaar na stopzetting van de therapie is het risico van borstkanker weer hetzelfde als bij vrouwen die nooit HST hebben gebruikt. Er blijkt geen verschil te zijn in het risico van borstkanker tussen specifieke preparaten of de wijze van toepassing.
Het College ter Beoordeling van Geneesmiddelen (CBG) adviseert de artsen om bij het voorschrijven van HST een zo laag mogelijke effectieve dosis te gebruiken, voor een zo kort mogelijke duur. Met name bij langdurig gebruik moeten de voordelen van HST worden afgewogen tegen het verhoogde risico van optreden van borstkanker.

Verhoogd risico door anticonceptiepil

Vrouwen die de pil slikken hebben een verhoogd risico van 24% op het krijgen van borstkanker in vergelijking tot vrouwen die de pil niet slikken. Voor vrouwen die 1-4 jaar geleden zijn gestopt met de pil is er een verhoogd risico van 16%. Vrouwen die 5-9 jaar geleden zijn gestopt met de pil, hebben een verhoogd risico van 7%. Voor vrouwen die al langer dan tien jaar geen anticonceptiepil meer slikken is er geen verhoogd risico meer. De duur van het gebruik van de anticonceptiepil, de dosis en de samenstelling hebben geen effect op het risico. Vrouwen die vůůr de leeftijd van 20 jaar beginnen met het slikken van de pil hebben een wat hogere kans op het krijgen van borstkanker gedurende het gebruik van de pil. Het absolute risico van borstkanker is echter laag in deze leeftijdsgroep (Collaborative Group on Hormonal Factors in Breast Cancer, 1996).

http://www.rivm.nl/vtv/object_document/o1497n17276.html


Tweede generatiepil verhoogt kans op borstkanker met 45%

De pil van de tweede generatie, die ook door zeer veel vrouwen wordt gebruikt, verhoogt de kans op borstkanker aanzienlijk. Dat blijkt uit een Noors onderzoek, waarvan de Sunday Times de resultaten publiceert.

Noorse artsen onderzochten 100.000 vrouwen tussen de 30 en 70 jaar om na te gaan hoeveel van hen te kampen kregen met borstkanker. Dat leidde tot de conclusie dat wie de 'tweede generatie-pil' meer dan drie jaar lang nam, 45 procent meer gevaar loopt om borstkanker te krijgen.

Volgens de Noorse medici, wier onderzoek in juli wordt gepubliceerd in de Internationl Journal of Cancer, is de kans op borstkanker voor gebruiksters van anti-conceptiepillen over de hele lijn 25 procent groter dan bij vrouwen die deze middelen niet gebruiken. Britse experts relativeerden de resultaten van het Noorse onderzoek en zeiden dat er 'verschillende factoren een rol spelen bij borstkanker, waarvan de pil er slechts ťťn is'.

Het Nederlands Tijdschrift voor Geneeskunde 20/05/03

http://www.levenmetborstkanker.nl/nieuwsbkenpil.html


Meer kankerrisico met 1 pil dan met 10 ton verboden hormonenvlees.

Al vele jaren vinden de artsen dat het vlees van hormoongestimuleerde runderen moet verboden worden omdat de residuhormonen een hoog kankerrisico teweegbrengen. De auteur vindt dat terecht doch rekent en herrekent dat men ruim 100 kg rundvlees (0,3 parts per billion) moet eten om evenveel oestrogenen op te nemen als ťťn dagelijkse hormonenpil. Omdat de pil thans geprepareerd is met het 100 maal sterker werkend ethinylestradiol zou men moeten 10.000 kg rundvlees consumeren - of circa 50 runderen - om evenveel kankerrisico in ons lichaam te induceren!!! En dan niet vergeten dat de pil dagelijks wordt genomen. Dus het door de geneeskunde (wegens kankerrisico) verboden hormonen-beefsteak is 10.000 maal minder gevaarlijk dan de dagelijks voorgeschreven contraceptieve pil! Aldus de auteur.

http://www.viow.be/archief/actueel/pers/boekbespreking.htm


Borstkanker en remming door Lima Bonen

Lunatusin, a trypsin-stable antimicrobial peptide from lima beans (Phaseolus lunatus L.).

Wong JH, Ng TB. Department of Biochemistry, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, China.

An anti-fungal peptide designated as lunatusin, with a molecular mass around 7kDa, was purified from the seeds of Chinese lima bean (Phaseolus lunatus L.). The peptide was isolated using a simple protocol consisting of affinity chromatography on Affi-gel blue gel and gel filtration on Superdex 75. Lunatusin exerted an anti-fungal activity toward fungal species such as Fusarium oxysporum, Mycosphaerella arachidicola and Botrytis cinerea, and an antibacterial action on, Bacillus megaterium, Bacillus subtilis, Proteus vulgaris and Mycobacterium phlei. It also inhibited proliferation in the breast cancer cell line MCF-7. Lunatusin reduced the activity of HIV-1 reverse transcriptase and it also inhibited translation in a cell-free rabbit reticulocyte lysate system. Its anti-fungal activity was retained after incubation with trypsin. Lunatusin elicited a mitogenic response from mouse splenocytes.

Peptides. 2005 Nov;26(11):2086-92. Epub 2005 Apr 25

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&
db=pubmed&dopt=Abstract&list_uids=16269344&query_hl=
6&itool=pubmed_docsum


Borstkanker - praktijkverhaal

Dat er bij mijn vrouw borstkanker werd vastgesteld is een gegeven dat inslaat als een bom , bij zowel patient als familie(echtgenoot ).
Dat snelle hulp vereist is mag duidelijk zijn en ik moet zeggen dat dat allemaal snel geregeld was. Er werd een borstbesparende operatie gedaan en die is goed verlopen. Maar bij het vervolg trajekt zijn er toch verschillende dingen niet goed gegaan, welke ik uit de doeken zal doen.

Bij het geregeld bellen en nakijken op websites van verenigingen welke kanker in hun takenpaket hebben, werd ik uiterst korrekt behandeld en van
informatie voorzien. Daar zijn wij dankbaar voor . Maar toen mijn vrouw voor controle moest naar Daniel de Hoedkliniek en het Dijkzichtziekenhuis werden er wel gesprekken gehouden, maar er werd niet bijverteld dat er ook alternatieve middelen waren.

Op een tip van een dezer verenigingen kwam ik op de website Kanker-aktueel en na lang zoeken bleek dat er WEL een alternatievemethode is en dat dat de ASAM-test is. Deze komt uit Amerika, kost 160 dollar en is zo goed en eenvoudig dat deze test voor 99 0/0 nauwkeurig is . Ook bij bestralingen geven artsen geen 100 0/0 garantie . Zelf ben ik nu ook onder behandeling van een arts, en die zei het vreemd en niet goed te vinden dat artsen van grote ziekenhuizen geen informatie geven aan zulke patienten.

Mijn redenatie is dat je alles stap voor stap moet doen en eerst een eenvoudige test kan doen en dan pas moet bestralen als er nog kankercellen zitten. De bijwerkingen van bestraling kunnen van patient tot patient verschillen . Maar ik ben van mening dat Professoren, Radiotherapeuten of wat het nog meer mag zijn verplicht zijn om duidelijke onhafhankelijke informatie te geven. De mediche wereld denkt dat iedereen maar achter hun aanholt en dat hun het allemaal wel weten. Maar ik ben bang dat er een soort tunnelvisie ontstaat en dat zij altijd gelijk hebben.

Daarom wil ik dit aan de kaak stellen , ik begrijp ook wel dat niet iedereen het met mij eens is. Maar als ik dan hoor uit betrouwbare bron dat deze test al bij verschillende personen goed heeft gewerkt dan zet ik mijn vraagtekens bij het verzwijgen hiervan. Ik denk dat geld hiervan de oorzaak is, grote dure apparatuur moet werken en een eenvoudige test zou dat wel eens kunnen doorkruisen. Ik hoop dat mensen die dit lezen zelf eens op zoek gaan naar Kanker-aktueel en zelf kunnen bepalen wat ze willen en niet aan de halsband van dure doktoren moeten lopen .

A. De Haan, Schiedam
havikuil@planet.nl


Ginseng zorgt voor grotere overlevingskans bij borstkanker

Vrouwen die het kruid Ginseng gebruiken hebben een grotere kans om borstkanker te overleven en een beter kwaliteit van leven te hebben na de behandeling blijkt uit een nieuwe Chinese studie.

De studie volgde gedurende 6 jaar 1455 Chinese vrouwen die behandeld waren voor borstkanker. De vrouwen die reeds Ginseng gebruikten hadden een 30% kleinere kans op te overlijden tijdens de 6 jaar die zij gevolgd werden.

De vrouwen die Ginseng pas na de diagnose gingen gebruiken voelden zich emotioneel beter en hadden een aktiever sociaal leven dan de vrouwen die geen Ginseng gebruikten.

http://today.reuters.com/news/newsArticle.aspx?type=healthNews


International


 

 


 
Pregnancy nausea/vomiting may indicate lower risk of breast cancer

It may not seem so at the time, but women who suffer through morning sickness during their pregnancies actually may be fortunate. Those women may have a 30 percent lower risk of developing breast cancer later in life than mothers-to-be who experience nine nausea-free months, a new study by epidemiologists at the University at Buffalo suggests.

http://www.buffalo.edu/news/8704


 
Elderly breast cancer care 'poor Breast cancer scan

Older women with breast cancer get poorer care than younger women, a study has found. Researchers from the University of Manchester found they are less likely to get a range of diagnostic tests and treatments. Writing in the British Journal of Cancer, they say this is likely to lead to higher rates of cancer recurring, and higher death rates. [Ben Licher]

http://news.bbc.co.uk/2/hi/health/6510229.stm


 
Revolutionary Invention May Aid in the Prevention of Breast Cancer

Medical anthropologist Sidney Ross Singer and his colleagues theorized that conventional brassieres may contribute to the development of breast cancer because they constrict the lymph glands, which are the "garbage collectors" of the body. If lymph flow is restricted, it is difficult for toxins to be removed from the breast area and, over time, those toxins may accumulate and, in turn, promote disease.

http://www.genengnews.com/news/bnitem.aspx?name=15160229


 
Breast Cancer Deaths Declining

Patients Younger Than 70 With Estrogen-Sensitive Tumors Show Steepest Drop. U.S. women's breast cancer deaths dropped 24 percent from 1990 to 2003, a new study shows. Women younger than 70 with estrogen-sensitive breast cancers had the biggest decline in breast cancer deaths during that period. [Ben Licher]

http://www.cbsnews.com/stories/2007/04/04/health/webmd/
main2648795.shtml?source=RSSattr=Health_2648795


 
Low-Fat Diet and Chronic Disease Prevention

The Women’s Health Initiative Randomized Controlled Dietary Modification Trial was designed to study a low-fat diet, a nutritional approach to prevention of chronic diseases that was considered promising. The negative findings from the trial were both unexpected and disappointing to nutrition authorities. The authors’ public responses to the findings articulated an unwillingness to believe the finding that a low-fat diet did not prevent breast or colon cancer or heart disease. The negative results should stimulate work on alternate hypotheses, and reconsideration of the long-standing proscription against dietary fat.

http://www.jpands.org/vol12no1/ottoboni.pdf


 
Lignans likely to lessen breast cancer risk

Ms Williamson’s study involved two trials with healthy postmenopausal women. The answer to reducing your risk of breast cancer could very well come down to flaxseeds, according to the latest research by an RMIT University postgraduate researcher.

http://www.rmit.edu.au/browse;ID=c4gpdfmuqslc


 
Plant-based diet fights cancer

A new study in the Journal of Clinical Oncology shows that women with breast cancer can greatly reduce their risk of cancer recurrence by exercising and eating a plant-based diet rich in fruits and vegetables.

http://www.ironwooddailyglobe.com/0620vega.htm


 
216 environmental compounds caused breast cancer in animals.

The free, searchable database reveals that exposure to potential breast cancer-causing agents is widespread from chemicals used in consumer products, food, women's workplaces, and in air and water pollution. The database includes references to 900 studies of which 460 are human breast cancer studies. The researchers stressed that 29 of the potential cancer-causing carcinogens are found in massive amounts in the U.S., but little is known yet about their effects on human health. The database shows 216 environmental pollutant compounds that cause breast cancer in animals including73 that are present in consumer products or as contaminants in food. Ten of these are registered with the FDA for use as food additives, 35 are air pollutants, 29 are produced in the United States in large amounts, often exceeding 1 million pounds per year, 25 have been associated with occupational exposures affecting more than 5,000 women a year.

http://www.associatedcontent.com/article/245469/environmental_factors_in_breast_cancer.html


 
Breast Cancer and Chemical Exposure

A groundbreaking research study coordinated by the non-profit Silent Spring Institute and recently published by the American Cancer Society found that synthetic chemicals have likely played a large role in the rising incidence of breast cancer throughout the world over the last half-century. The study identified 216 man-made chemicals — including those found in everyday products like pesticides, cosmetics, dyes, drugs and gasoline (and diesel exhaust) — that have been shown to cause breast cancer in animals.

http://www.swnewsherald.com/online_content/2007/06/et061807cancer.php


 
RPCI finds chemical links to breast cancer

An analysis co-authored by a Roswell Park Cancer Institute researcher found that common chemicals, such as car exhaust and grilled food, cause breast cancer in animals. The research team analyzed hundreds of studies that linked environmental exposures and the disease. The team included Kirsten Moysich from Roswell and researchers from four institutions in the Boston and Los Angeles areas.

http://washington.bizjournals.com/buffalo/stories/2007/05/14/daily14.html


 
Soy estrogens and breast cancer - Researcher offers overview

Are soy products healthy additions to a person’s diet, safe alternatives to hormone-replacement therapy or cancer-causing agents? The answer, according to University of Illinois food science and human nutrition professor William Helferich, is, "It depends."

http://www.news.uiuc.edu/news/07/0516helferich.html


 
Estrogens Shield Breast Cancer Cells

Among the more insidious aspects of cancer is its capacity for escaping the anticancer defenses of the host. New research suggests that some estrogens may further reinforce this evasion of host immunity, even as those same hormones stimulate the growth and spread of hormone-responsive cancers. According to David Shapiro, a medical and biochemistry professor at the University of Illinois at Urbana–Champaign, the new findings highlight the role that estrogen-related interference with immune cell function may play in the development and progression of breast cancer.

http://www.ehponline.org/docs/2007/115-6/forum.html#estr


 
A genetic 'gang of 4' drives spread of breast cancer

Studies of human tumor cells implanted in mice have shown that the abnormal activation of four genes drives the spread of breast cancer to the lungs. The new studies by Howard Hughes Medical Institute researchers reveal that the aberrant genes work together to promote the growth of primary breast tumors. Cooperation among the four genes also enables cancerous cells to escape into the bloodstream and penetrate through blood vessels into lung tissues.

http://www.hhmi.org/news/massague20070412.html


 
Drug Industry Increasingly Influences Breast Cancer

Breast cancer treatment trials supported by the pharmaceutical industry are more likely to report positive results than non-sponsored studies, according to a study to be published in the April 1, 2007 issue of CANCER, a peer-reviewed journal of the American Cancer Society. In addition, there are significant differences in the design of trials and types of questions addressed by pharmaceutical industry sponsored trials compared to non-sponsored trials. The study is the first to examine the impact of the pharmaceutical industry on breast cancer research.

http://cancerfocus.net/node/255


 
American College of Physicians warns women in their 40s about dangers of mammograms

The American College of Physicians has recommended women in their 40s consult with their doctors before undergoing routine annual mammography screening. An expert panel from the American College of Physicians (ACP), which represents 120,000 internists, made this recommendation in the April 3rd issue of the journal Annals of Internal Medicine. After reviewing 117 studies conducted between 1966 and 2005, the panel found the data on mammography screening for women in their 40s are so unclear that the effectiveness of reducing breast cancer death could be either 15 percent or "...nearly zero." The panel pointed out that benefits must be weighed against the harmful effects of mammograms, including exposure to radiation and unnecessary biopsies, surgery, and chemotherapy.

http://www.newstarget.com/021849.html


 
Singapore scientists find risk gene for breast cancer

Scientists have discovered a risk gene for breast cancer, according to a local media Channel NewsAsia report on Monday. Scientists from the Genome Institute of Singapore and the Karolinka Institute, together with over 20 other international collaborating research groups, made the discovery from a research involving 30,000 women, half of whom have breast cancer.

http://english.people.com.cn/200702/27/eng20070227_352606.html


 
Sharp Drop in Rates of Breast Cancer Holds

Breast cancer rates fell sharply in 2003, and the lower rate remained in 2004, researchers are reporting today.The most likely reason for the fall in rates, the investigators, led by Donald A. Berry of M. D. Anderson Cancer Center in Houston, said, was that largenumbers of women stopped taking hormone therapy for menopause. [Ben Licher]

http://www.nytimes.com/2007/04/19/health/19breast.html?ex=
1334635200&en=879fbb249b8d9f81&ei=5088&partner=rssnyt&emc=rss


 
Traditional Chinese Medicinal Herbs May Help Women With Breast Cancer

Using Chinese herbs either alone or in conjunction with chemotherapy may help protect a breast cancer patient's bone marrow and immune system,as well as improving the woman's overall quality of life. [Ben Licher]

http://www.sciencedaily.com/releases/2007/04/070417194320.htm


 
Risk of Second Primary Cancer in Men with Breast Cancer

A retrospective registry-based cohort study was conducted to examine the risk of second primary cancer following the occurrence of breastcancer in males. Conclusion - Male breast cancer patients should be monitored carefully for the occurrence of second primary cancers, especially a second primary breastcancer. [Ben Licher]

ttp://www.medscape.com/viewarticle/553851?rss


 
Fitness gains last in breast cancer survivors

In a recent study, women getting over breast cancer treatment who participated in an 8-week supervised aerobic and strength training program improved their physical fitness and quality of life. Now, a follow up study of the women indicates that some of the physical fitness gains last well beyond the training period. [Ben Licher]

http://today.reuters.com/news/articlenews.aspx?type=healthNews&storyid=2007-04-06T161217Z
_01_SIB658319_RTRUKOC_0_US-FITNESS-BREAST.xml


 
Breast Cancer and Passive Smoking

Does a young woman living with a smoker or taking a job working in a smoky bar have a greater chance of developing breast cancer? Some scientists believe that such situations can indeed raise a woman's risk of developing breast cancer before the age of 50. Because epidemiological and toxicological studies show that women's breast tissue may be especially sensitive to exposure to carcinogens prior to first pregnancy, these researchers contend that public education should be directed at alerting adolescents and young women to the potential risk.

http://www.ehponline.org/members/2007/115-3/focus.html


 
Tonsil removal and breast cancer

Women who had their tonsils removed in childhood may be at increased risk of developing pre-menopausal breast cancer, according to University at Buffalo researchers.

http://news.moneycentral.msn.com/provider/providerarticle.aspx?
Feed=ACBJ&Date=20070420&ID=6776140


 
Breastfeeding Cuts Breast Cancer Risk

Breastfeeding can offset the increased risk of breast cancer faced by women who have their first baby after they turn 25, new research suggests. "Breastfeeding offers protection against breast cancer for all women, even those who have their first full-term pregnancy later in life," says Giske Ursin, MD, PhD, associate professor of preventive medicine at the Keck School of Medicine of the University of Southern California in Los Angeles.

http://www.webmd.com/breast-cancer/news/20070417/breastfeeding-cuts-breast-cancer-risk


 
Study Recommends Emu Oil to Reduce the Appearance of Scars From breast Surgery

A first of its kind study out of Albany, New York reported that patients recovering from post-operative breast surgeries show a dramatic improvement in scar healing and appearance after using an emu oil based treatment.

http://www.earthtimes.org/articles/show/news_press_release,96035.shtml


 
Black cohosh may cut breast cancer risk

A new study provides preliminary evidence that an herbal medicine used to help women cope with menopausal symptoms may reduce breast cancer risk.

http://uk.reuters.com/article/healthNews/idUKCOL66565720070426


 
Study May Explain Why Alcohol Consumption Boosts Breast Cancer Risk

This study presents the first animal model to confirm that alcohol consumption stimulates tumor growth and malignancy of breast cancer, and reveals some of the mechanisms of alcohol-induced breast cancer.

http://www.interestalert.com/story/04280002aaa05ec0.nw/pkreysa/
HELTHSCI/health/science.html


 
Device to Locate Magnetic Nanoparticles in Lymph Nod

High-temperature superconductors hold the key to a handheld tool for surgeons that promises to be more accurate, cost-effective and safer than existing methods for staging and treating various cancers, including breast cancer.

Audrius Brazdeikis, research assistant professor of physics in the College of Natural Sciences and Mathematics at the University of Houston, and Quentin Pankhurst, a professor of physics from the University College of London (UCL), have developed a novel detection procedure combining nanotechnology and advanced magnetic sensing based on high-temperature superconductors. Their innovation will enable surgeons to more effectively locate the sentinel lymph node – the first lymph node to which a tumor’s metastasizing cancer cells will drain.

The researchers produced an ultrasensitive magnetic probe to detect minuscule magnetic fields in the body. The probe is a supersensitive magnetometer – an instrument used to track the presence of clinically introduced magnetic nanoparticles. During breast cancer surgery, a surgeon will inject a magnetic nanoparticle dye, already approved as an imaging contrast agent by the Food and Drug Administration, into the tumor or into tissues surrounding the tumor.

http://www.uh.edu/admin/media/nr/2007/03march/030507abrazdeikis_bcprobe.html


 
Exercise May Improve Breast Cancer Survival Rates

The first study, based on interviews with 15,000 women, shows that women who get more than six hours of strenuous exercise a week, and have no family history of breast cancercancer, may be 23% less likely to develop the disease than women who don't exercise at all. The second study shows a 12-week group exercise program may boost mood and physical function in women with early-stage breast cancer. The researchers don't promise exercise will prevent breast cancer, or blame breast cancer on a lack of exercise. Many factors affect cancer risk.

http://www.webmd.com/content/article/131/118205?src=RSS_PUBLIC


 
Cosmetics, chemicals and breast cancer

The risk of a Canadian woman developing breast cancer in her lifetime is one in nine, but the causes are harder to pinpoint. Jeanne Rizzo, executive director of the San Francisco-based Breast Cancer Fund, will speak at McGill University on the need to curb the breast cancer epidemic by expanding the definition of prevention beyond routine screenings to include public-health policies that recognize the link between toxic chemicals and the rise in the disease. Ms. Rizzo’s talk, “Cosmetics, Chemicals and Breast Cancer,” is this year’s Muriel V. Roscoe Annual Lecture and Lanie Melamed Memorial Lecture. It will be held at New Residence Hall, Ballroom A, 3625 Parc, at 6 p.m. Tuesday, March 13. The Breast Cancer Fund’s goal is to eliminate the disease’s environmental and other preventable causes.

http://www.mcgill.ca/newsroom/news/?ItemID=24214


 
Addressing Chemical Exposures Through Policy and Market Based Campaigns

Founded in 1992, Breast Cancer Fund is the only national organization focused solely on preventing breast cancer by identifying and eliminating the environmental causes of the disease. Part of our work as advocates for prevention is to look at everyday chemical exposures that may be linked to breast cancer. The public is inundated with the message that “prevention is early detection.” Yet, more and more scientific evidence is linking increasing rates of breast cancer and other diseases to increased chemical exposures. Making these linkages understandable to the general public is best accomplished in a context that is easily understandable. The Campaign for Safe Cosmetics uses a market based campaign as well as a legislative strategy to seek reform of the largely unregulated cosmetics industry. It is also a useful and approachable way to talk about chemicals in consumer products that may be linked to cancer and cancer prevention. Through the work of the campaign, the public is being educated about toxic chemicals that are in the products they use every day. The Campaign also empowers the public to practice prevention in their daily lives while creating activists who are willing to speak out about unacceptable chemical exposures and demand greater corporate and government protections and accountability.

http://bcerc.org/2006mtg/abstracts/RizzoLee.pdf


 
Atrazine and similar reproductive cancers in people

Considering the prevalence of atrazine in the environment, the continued rise of cancer as the leading cause of death in the US (and with breast cancer and prostate cancer being the most common cancers in men and women, respectively), the current findings raise concern for the impact of atrazine on environmental and public health. This is especially troubling because African American and Hispanic Americans, more likely to be occupationally exposed to pesticides and less likely to have proper access to healthcare, are two to four times more likely to die from breast and prostate cancer.

http://www.ehponline.org/members/2007/9758/9758.pdf


 
Study aims to find which breast cancer patients need chemotherapy

Most postmenopausal women with small breast tumors don’t need chemotherapy to reduce their recurrence risk after lumpectomy. To try to determine who does, a test that measures a tumor’s aggressiveness based on its DNA will be tested nationally in more than 10,000 of these women. “The dilemma physicians have with these patients is, because they have such small tumors, it’s hard to tell who needs chemotherapy,” said Dr. Thomas A. Samuel, Medical College of Georgia hematologist/oncologist specializing in breast cancer and a study principal investigator.

http://www.mcg.edu/news/2007NewsRel/Samuel031207.html


 
Mammograms Offer No Health Benefits Whatsoever

An increasing number of doctors are contesting the claim that annual mammograms decrease women's risk of dying from breast cancer. Danish researcher Dr. Peter Gotzsche first made this claim in a study published in "The Lancet" in October 2006. Gotzsche had re-analyzed the studies originally done on the benefits of mammograms and found them unconvincing.

http://www.healthtruthrevealed.com/full-page.php?id=1656304602&&page=article


 
Breast cancer screening harms ten women for every one it helps

A new study by researchers from the Nordic Cochrane Centre in Denmark found that mammograms may harm ten times as many women as they help. The researchers examined the benefits and negative effects of seven breast cancer screening programs on 500,000 women in the United States, Canada, Scotland and Sweden. The study's authors found that for every 2,000 women who received mammograms over a 10-year period, only one would have her life prolonged, but 10 would endure unnecessary and potentially harmful treatments.

http://www.newstarget.com/020829.html


 
Changes In Breast Density May Impact Breast Cancer Risk

Changes in breast density within a three year period may impact breast cancer risk, according to a new study. The two measurements of breast density needed to calculate that change may better predict a woman's risk of breast cancer than a single measurement.

http://www.medicalnewstoday.com/medicalnews.php?newsid=64717&nfid=rssfeeds


 
Radiation for breast cancer ups heart disease risk

As a treatment for breast cancer, radiation, even modern regimens, appears to increase the risk of cardiovascular disease, according to a report in the Journal of the National Cancer Institute for March 7.Earlier reports have indicated that radiotherapy regimens used in the 1970s elevate heart disease risk, but it has been less clear if more recent regimens also increase the risk.

http://today.reuters.com/news/articlenews.aspx?type=healthNews&storyID=2007-03-07T030
921Z_01_TON711346_RTRUKOC_0_US-RADIATION-BREAST-CANCER.xml&page
Number=0&imageid=&cap=&sz=13&WTModLoc=NewsArt-C1-ArticlePage2


 
New radiation therapy gives breast cancer patients a more direct treatment option

MammoSite is a partial breast radiation treatment comprised of a balloon catheter that internally delivers radiation to the tumor. Treatment is completed in five days. And radiation exposure to the rest of the breast, skin, ribs, lungs and heart is minimized. Traditional external beam radiation typically is a six- to eight-week treatment that exposes the entire breast to the radiation.

http://www.shreveporttimes.com/apps/pbcs.dll/article?AID=/20070317/NEWS01/
703170346/1002/NEWS


 
Could chemopause be the answer to treat breast cancer?

The shutdown of the ovaries is called chemopause, and women who choose to go this route receive monthly injections -- considered a super-hormone treatment -- of a drug that blocks the male hormone testosterone and is often used to treat prostate cancer. Chemopause has big advantages. It doesn't require surgery. And it's not permanent. Women who want to have children can stop the treatment in order to conceive. And women who have trouble with side effects can discontinue use of the surgery-sparing drugs.

http://www.topcancernews.com/news/452/1/Could-chemopause-
be-the-answer-to-treat-breast-cancer%3F-


 
Link between immune system and mammary gland could shed new light on breast cancer

Scientists at the University of Cambridge have published new research today (July 5) in the journal Development showing an unexpected link between a fundamental part of the immune system and the cells that produce milk in the breast during lactation.

http://www.bbsrc.ac.uk/media/pressreleases/07_07_05_cytokines.html


 
Surgeon Develops Procedure To Prevent Arm Swelling In Breast Cancer Patients

A surgeon at the University of Arkansas for Medical Sciences (UAMS) has developed a new procedure to prevent one of the most common side effects associated with breast cancer treatment – lymphedema or swelling of the arms due to faulty drainage of the lymph nodes.

V. Suzanne Klimberg, M.D., director of the UAMS breast cancer program, led a study funded by the Tenenbaum Breast Cancer Research Foundation of breast cancer patients at risk for developing lymphedema. Her findings were published in the February issue of the Annals of Surgical Oncology, and she will present the study March 17 at the Society of Surgical Oncology 60th Annual Cancer Symposium in Washington, D.C.

“The removal and analysis of the lymph nodes under the arm remains the most important factor in determining the severity of disease in breast cancer patients,” Klimberg said. “In the past, surgery to remove the lymph nodes and most of the fat and tissue in the armpit often resulted in complications, including lymphedema.” Five percent to 50 percent of women undergoing surgical treatment for breast cancer have developed lymphedema, mainly dependent upon the extent of surgery.

http://www.uams.edu/update/absolutenm/templates/news_release_
andrea.asp?articleid=6124&zoneid=35


 
High-fat diet may increase breast cancer risk

High-fat diet may increase breast cancer risk A large study of middle-age women with a wide range of fat in their diet shows that eating a high-fat diet raises the risk of developing invasive breast cancer.

http://today.reuters.com/news/articlenews.aspx?type=healthNews&storyid=
2007-03-20T215954Z_01_WRI079166_RTRUKOC_0_US-HIGH-FAT-DIET.xml


 
UBC Discovery May Lead to “Smart” Therapies for Breast, Ovarian Cancer

New non-toxic and targeted therapies for metastatic breast and ovarian cancers may now be possible, thanks to a discovery by a team of researchers at the University of British Columbia.

In a collaboration between UBC stem cell and cancer scientists, it was found that a protein called podocalyxin -- which the researchers had previously shown to be a predictor of metastatic breast cancer -- changes the shape and adhesive quality of tumour cells, affecting their ability to grow and metastasize. Metastatic cancer is invasive cancer that spreads from the original site to other sites in the body.

The discovery demonstrated that the protein not only predicted the spread of breast cancer cells, it likely helped to cause it. The findings were recently published online by the Public Library of Science.

“We believe we’ve found a new important culprit in metastatic breast cancer, which opens up an entirely new avenue of cancer research,” says Calvin Roskelley, an associate professor of cellular and physiological science who specializes in breast cancer and is co-senior principal investigator. “The culprit is hiding in plain sight on the surface of tumour cells, so we are now developing “smart” molecules to block its function. The ultimate goal is to generate new targeted, non-toxic treatments -- very different from the standard ‘slash and burn’ chemotherapy.”

http://www.publicaffairs.ubc.ca/media/releases/2007/mr-07-028.html?src=ubcca


 
Src inhibitors may prove beneficial in breast cancer therapy

Estrogen, which binds estrogen receptor alpha (ER-alpha), is a risk factor for breast cancer development. However, one-third of new breast cancers lack detectable ER-alpha. These ER-alpha–negative cancers are more aggressive and have a worse prognosis than do ER-alpha–positive breast cancers, and have been thought to be estrogen independent. In a new JCI study, University of Miami researchers shed further light on the mechanisms regulating ER-alpha expression levels during breast cancer.

http://www.jci.org/cgi/content/abstract/JCI21739v1


 
Tykerb - New drug for advanced HER2 breast cancer

Like Herceptin, Tykerb zeros in on and blocks the effects of HER2, a protein that is overproduced in certain breast cancers, stimulating their growth. Both drugs are referred to as "targeted" because of this specificity. Herceptin blocks HER2's action from the outside of the cell. Tykerb, on the other hand, works on the inside of the cell. This difference may explain why Tykerb works for some women for whom Herceptin is no longer effective. The FDA approved Tykerb on the basis of a study of 400 women, half of whom received the new drug in combination with Xeloda for a 21-day treatment cycle, while the other half were given Xeloda alone. In the combination group, tumors took longer to start growing again. Although considered statistically significant, the average time difference between the two groups was only a little more than eight weeks.

http://www.mayoclinic.com/health/tykerb/DI00082


 
Plant estrogens may help cut cancer risk

French researchers say a diet rich in lignans may help prevent breast cancer in older women.

http://www.upi.com/NewsTrack/Top_News/Plant_estrogens_may_help
_cut_cancer_risk/20070321-053517-7811r/


 
Dietary Lignan Intake and Postmenopausal Breast Cancer Risk by Estrogen and Progesterone Receptor Status

High dietary intakes of plant lignans and high exposure to enterolignans were associated with reduced risks of ER- and PR-positive postmenopausal breast cancer in a Western population that does not consume a diet rich in soy.

http://jnci.oxfordjournals.org/cgi/content/abstract/99/6/475


 
Study finds Western-style 'meat-sweet' diet increases risk of breast cancer in postmenopausal women

A new study finds that the more "Western" the diet -- marked by red meat, starches and sweets -- the greater the risk for breast cancer among postmenopausal Chinese women. According to researchers who conducted the analysis at Fox Chase Cancer Center in Philadelphia, Harvard University, Shanghai Cancer Institute and Vanderbilt University, the findings mark the first time a specific association between a western diet and breast cancer has been identified in Asian women.

http://www.aacr.org/home/about-us/news.aspx?d=791


 
Study Fails to Show Benefits of Fruits and Veggies for Breast Cancer Patients Women are Blamed, but the Investigators Were at Fault

The meat and dairy industry must have been laughing all the way to the bank on Tuesday July 17, 2007 when headlines worldwide announced the results of a seven-year diet experiment, known as The Women’s Healthy Eating and Living (WHEL) Randomized Trial, of more than 3,000 women with breast cancer. This government funded study (kicked off by a $5 million grant from the late Wal-Mart heir John Walton with an additional $30 million in support from the National Cancer Institute) found no benefit from recommending that women with breast cancer eat more fruits and vegetables, and less fat. The chances of fewer recurrences and better survival were not seen in women previously treated for breast cancer after changes in diet achieved during this study. As a result of this paper, originally published in the Journal of the AmericanMedical Association, more people now believe healthier eating will not help women prevent or treat breast cancer.

http://www.drmcdougall.com/misc/2007other/070723study.htm


 
Test detects the spread of breast cancer

The first molecular-based laboratory test for detecting whether breast cancer has spread (metastasized) to nearby lymph nodes was approved by FDA on July 16, 2007.

http://www.newsfood.com/Articolo/International/20070721-Test-detects-
spread-breast-cancer.asp


 
Postmenopausal Sex Hormones and Breast Density Are Each Associated with Breast Cancer Risk

Sex hormone levels and breast density are independent risk factors for breast cancer in postmenopausal women. Breast density and hormone levels are both well-known predictors of breast cancer, but it is unclear whether hormone levels regulate breast density. Rulla Tamimi, Sc.D., of Brigham and Women’s Hospital in Boston and colleagues measured breast density and estrogen and testosterone levels in postmenopausal women who later developed breast cancer and those who did not. They found that sex hormone levels and breast density are strongly and independently associated with breast cancer risk.

http://www.eurekalert.org/pub_releases/2007-07/jotn-hi071907.php


 
More Evidence for Breast Cancer Declines as HRT Use Drops

Researchers here believe they've successfully tied a recent decline in breast cancer incidence to the rapid drop in use of hormone replacement therapy after 2002.

http://www.medpagetoday.com/HematologyOncology/BreastCancer/tb/6265


 
Survival Disadvantage Seen for Triple-Negative Breast Cancer

A new study clearly reveals the survival disadvantage for the so-called "triple-negative" subtype of breast cancer compared with other types of breast cancer. These tumors test negative for estrogen receptor (ER), progesterone receptor (PR), and the human epidermal growth factor receptor 2 (HER2) and do not respond to any form of endocrine therapy. [Ben Licher]

http://www.medscape.com/viewarticle/554234?rss


 
Industry Breast Cancer Trials More Often Positive

Breast cancer studies supported by drug companies are more likely to report positive results than those without pharmaceutical industry backing, according to a new study.

http://www.cancer.org/docroot/NWS/content/NWS_1_1x_Study_
Industry_Breast_Cancer_Trials_More_Often_Positive.asp


 
Scientists Develop New Detector for Breast Cancer

Medical researchers may have a new way to find diseased cells when screening for breast cancer. Scientists from Harvard University Medical School have developed a chemical that highlights cancerous tumor cells.

http://chicagopublicradio.org/Cityroom_Story.aspx?storyID=9606


 
Scientists develop new drugs to fight colon and breast cancer more effectively

A new technique called "microarrays" was used in this study, which enables the identification of the specific effects produced by drugs on each human gene. The study, conducted in the Department of Human Anatomy and Embryology at the University of Granada, looked at six new compounds which reduce the side effects of cancer treatment. Results available in Tetrahedron.

http://prensa.ugr.es/prensa/research/verNota/prensa.php?nota=439


 
Intake of vitamin D and calcium associated with lower risk of breast cancer before menopause

Women who consume higher amounts of calcium and vitamin D may have a lower risk of developing premenopausal breast cancer, according to a report in the May 28 issue of Archives of Internal Medicine, one of the JAMA/Archives journals.

http://www.eurekalert.org/pub_releases/2007-05/jaaj-iov052407.php


 
Traditional Chinese medicinal herbs may help women with breast cancer

Using Chinese herbs either alone or in conjunction with chemotherapy may help protect a breast cancer patient’s bone marrow and immune system, as well as improving the woman’s overall quality of life.

Sixty per cent of women undergoing chemotherapy for breast cancer experience a range of significant short term side effects. These include nausea, vomiting and fatigue, as well as inflammation of the gut lining, decreased numbers of red and white blood cells and decreased numbers of blood platelets.

Chinese medicinal herbs include mixtures of herbal compounds or extracts from herbs, and they are prescribed to counteract the side effects of chemotherapy. This Cochrane Systematic Review set out to see if there is conventional evidence indicating that these medicines are safe and whether there is evidence that the medicines are effective.

The researchers identified seven randomised studies involving 542 patients with breast cancer.

http://www.cochrane.org/press/wiley/2007.04.18.TCL_Breast_
Cancer_Release_April_2007_FINAL.pdf


 
Cryoablation is a safe procedure for breast cancer patients, early results indicate

Ultrasound-guided cryoablation of small breast cancer may be a safe procedure associated with minimal morbidity and high patient satisfaction, according to a recent case report by radiologists at the University of Wisconsin Hospital & Clinics in Madison, Wis.

http://www.arrs.org/pressroom/info.cfm?prID=215


 
Scientists develop new drugs to fight colon and breast cancer more effectively

A new technique called "microarrays" was used in this study, which enables the identification of the specific effects produced by drugs on each human gene. The study, conducted in the Department of Human Anatomy and Embryology at the University of Granada, looked at six new compounds which reduce the side effects of cancer treatment. Results available in Tetrahedron.

http://prensa.ugr.es/prensa/research/verNota/prensa.php?nota=439


 
Avocado extract can boost power of breast cancer drug

A toxin found in avocados could improve the disease-killing effects of the major breast cancer drug Tamoxifen, scientists believe.

http://www.nzherald.co.nz/section/story.cfm?c_id=204&objectid=10444008


 
Test Score Reveals Which Breast Cancer Patients Can Avoid Chemo

A new prospective study shows a 21-gene test of a patient’s breast cancer tumor may change doctor and patient treatment decisions, including the need for chemotherapy. Researchers at Loyola University Health System, Maywood, Ill., presented the findings at the American Society of Clinical Oncology annual meeting.

http://www.dentalplans.com/articles/19086/


 
Taking calcium, vitamin D before menopause reduced risk

New research gives women another good reason to get plenty of bone-strengthening calcium and vitamin D - The nutrients may reduce the risk of developing breast cancer.

http://www.thestate.com/166/story/77717.html


 
Deakin University research finds rogue cells that could cause spread of breast cancer

A Deakin University study has shed light on what causes breast cancer cells to move to other parts of the body.

http://www.eurekalert.org/pub_releases/2007-06/ra-dur061307.php


 
Fat tissue-derived hormone leptin increases e-cadherin expression, obesity-breast cancer link noted

Being obese increases the risk of breast cancer in post-menopausal women, shortens the time between return of the disease and lowers overall survival rates. Researchers now report evidence on how leptin, a hormone found in fat cells, significantly influences breast cancer development and progression in mice.

http://www.eurekalert.org/pub_releases/2007-04/foas-fth042107.php


 
BBQ lovers may have higher breast cancer risk

Dr Susan E Steck of the University of South Carolina in Columbia and her colleagues found that post-menopausal women who consumed the most grilled, barbecued or smoked red meat over their lifetime have a 47 percent increased risk of breast cancer.

http://www.iol.co.za/index.php?click_id=31&art_id=
nw20070503215303230C513253&set_id=


Early screening for breast cancer may do more harm than good

A new study reveals that screening women for breast cancer under the age of 50 might actually do more harm than good, since of every 10,000 women screened, a small percentage is actually diagnosed and of these, eventually only 4 are completely cured. In the bargain thousands of women face high levels of radiation which increase cancer risk, as well as suffer great emotional anxiety and add to government costs.

http://www.earthtimes.org/articles/show/12530.html


Pro-vitamin E shown to be active against breast cancer cells

A precursor of vitamin E has been shown to be effective against breast cancer cell lines which over-express human epidermal growth factor receptor (HER2).  About 30% of breast cancers exhibit high levels of HER2 – a feature that appears to make the disease resistant to many common treatments including chemotherapeutic agents. Now researchers in Griffith University’s School of Medical Science have shown that pro-vitamin E or alpha-tocopheryl succinate can reduce tumour volume in experimental animals with high levels of HER2. Chief investigator Associate Professor Jiri Neuzil said alpha-tocopheryl succinate (alpha-TOS) had the potential to be an inexpensive, safe and selective therapy for hard-to-treat breast cancers.

http://www.eurekalert.org/pub_releases/2006-12/ra-pe120706.php


Indiana University researchers discover unique marker to identify breast cancer protein

Researchers at Indiana University School of Medicine have discovered a way to identify a key protein in breast cancer cells, raising hopes that it will lead to a significantly better method for early detection of the disease.

The research, led by Linda H. Malkas, Ph.D., Vera Bradley Professor of Oncology and professor of medicine, and Robert J. Hickey, Ph.D., associate professor of medicine, involves a protein, PCNA, that plays a vital role in the processes that control cell replication, repair and death. The research team identified an antibody that can differentiate between the normal form of PCNA and the altered form found in breast cancer cells, Dr. Malkas said.

http://www.eurekalert.org/pub_releases/2006-12/iu-iur112906.php


Breast Cancer Regimen Linked to Cognitive Decline

As a treatment for high-risk breast cancer patients, high-dose cyclophosphamide, thiotepa, and carboplatin (CTC) is associated with a drop in cognitive performance over time, new research shows. Previous reports have shown a drop in cognitive performance among breast cancer survivors treated with cytotoxic therapy, the researchers note in the Journal of the National Cancer Institute.

http://www.cancerpage.com/news/article.asp?id=10368


Benefit of Aerobic Exercise During Radiation Therap

Moderate-intensity exercise, such as a brisk 20-minute walk three or more times a week, maintains or even increases erythrocyte levels during radiation therapy for breast cancer, researchers report in the November 15th issue of Cancer.

http://www.cancerpage.com/news/article.asp?id=10365


New biomarker predicts effectiveness of breast cancer drugs

University of Cincinnati researchers have identified a new way to predict when anti-estrogen drug therapies are inappropriate for patients with hormone- dependent breast cancer. Researchers suggested the findings could help physicians more accurately predict which tumors will respond to anti-estrogen therapy and improve long-term survival for breast cancer patients.

http://www.pharmaceutical-business-review.com/article_news.asp?
guid=A6F68E91-3DD9-42B9-8932-097570974BF4


Antibody Extends Life of Mice with Breast Cancer

A monoclonal antibody developed by researchers at the University at Buffalo has been shown to extend significantly the survival of mice with human breast-cancer tumors and to inhibit the cancer's spread to the lungs in the animals by more than 50 percent.

The antibody, named JAA-F11, targets a particular disaccharide, an antigen known as TF-Ag, which aids the adhesion and spread of certain cancer cells. While the antibody did not kill the cancer cells, it blocked stages of cancer-cell growth that allow the cells to adhere to organ tissue, the research showed.

http://www.buffalo.edu/news/fast-execute.cgi/
article-page.html?article=82850009


Breast Cancer Drop Tied to Hormones

U.S. breast cancer rates plunged an unprecedented 7 percent in 2003, the year after millions of women stopped taking menopause hormones when a study showed the pills raise the risk of tumors.

http://www.forbes.com/entrepreneurs/feeds/ap/2006/12/14/ap3256694.html


Vitamin D may help curb breast cancer

Vitamin D may help curb breast cancer progression, according to a study published in the Journal of Clinical Pathology.

The authors, from Imperial College, measured the levels of vitamin D in the blood serum of 279 women with invasive breast cancer. The disease was in its early stages in 204 of the women, and advanced in the remaining 75.

The results showed that women with early stage disease had significantly higher levels of vitamin D (15 to 184 mmol/litre) than the women in the advanced stages of the disease (16 to 146 mmol/litre).

http://www1.imperial.ac.uk/medicine/news/p61710_1/


Wyeth Hormone Sales Rise Even After Linked to Cancer

Revenue from the pills, used to treat symptoms of menopause, is expected by analysts to rise about 5 percent annually for the next several years. A study last week said reported cases of breast cancer in the U.S. dropped by 7 percent after use of Wyeth's hormone drugs fell by half from 2002 to 2004.

http://www.bloomberg.com/apps/news?pid=20601103
&sid=aPC0oAxHjQjg&refer=news


Daily dose of mushrooms could prevent breast cancer

Eating mushrooms on a daily basis could help prevent the development of breast cancer, researchers have found. Researchers from the Beckman Research Institute, California, found that extracts of the fungi interfere with the action of aromatase, an enzyme that helps the body to make oestrogen, which has long been linked to the growth spread of most breast cancer tumours.

http://www.dailytimes.com.pk/default.asp?page=2006%
5C12%5C21%5Cstory_21-12-2006_pg7_7


Low-fat diet can help prevent breast cancer recurrence

The study of more than 2,400 women, ages 48 to 79, found the rate of cancer recurrence after five years was 9.8 percent among women who ate a low-fat diet (about 33 grams of fat per day) and 12.4 percent among those who ate a standard diet (about 52 grams of fat per day).

http://www.poughkeepsiejournal.com/apps/pbcs.dll/article?
AID=/20061224/NEWS06/612240309


Hormones and breast cancer

When researchers reported recently that a precipitous drop in breast cancer rates might be explained by a corresponding decrease in the use of hormones for menopause, women reacted with shock, anger and, in some cases, profound relief that they had never taken the drugs.

http://www.nytimes.com/2006/12/26/health/26horm.html?_


Work in clothing, textiles linked to breast cancer

Women who work in certain industries may face a greater risk of breast cancer, according to a study from Israel.

http://www.modernmom.com/content/2431


Timing of weight gain affects breast cancer risk

New mothers now have even more incentive to shed pounds gained during pregnancy, other than wanting to fit into those pre-pregnancy jeans. A new study indicates an association between gaining weight in adulthood and an increased risk of breast cancer after menopause.

http://today.reuters.co.uk/news/newsArticle.aspx?
type=healthNews&storyID=2006-12-27


Stanford links breast cancer to hormone pills

A Stanford study that shows breast cancer rates are linked to the use of hormone replacement therapy drugs mirrors the findings of a recent national study. These findings will create a "conundrum" for doctors in the coming year as women suffering from menopausal symptoms, including fatigue and memory loss, seek safe treatments, according to the Stanford University School of Medicine.

http://www.paloaltodailynews.com/article/2006-12-27-stan-hormone


Fruits and veggies may help prevent breast cancer

Ambrosone found just ten servings of fruits and veggies a week lowers breast cancer risk by 1/3 among women with a certain gene most have.

http://www.wave3.com/Global/story.asp?S=5861845&nav=0RZF


Exercise may increase breast cancer survival for young women

Overweight or obese young women who report moderate or vigorous physical activity during the year prior to their breast cancer diagnosis have increased five-year survival, researchers from the University of North Carolina at Chapel Hill have found. The results show a modest improvement in long-term survival for all women ages 20 to 54 years old who were active just before breast cancer diagnosis. The effects of physical activity were most significant for women with a body mass index greater than 25. Understanding the link between breast cancer and lifestyle factors such as exercise can help explain variation in survival rates among women, said Dr. Page Abrahamson, who conducted the study as a graduate student in UNC's School of Public Health. "Disease stage and tumor grade are estimated to only explain about 20 percent of variation in survival. Identifying other factors that affect prognosis will help us identify women at increased risk of death and provide more ways for patients to enhance their survival," said Abrahamson, now a postdoctoral researcher at the Fred Hutchinson Cancer Center in Seattle, Wash.

http://www.unc.edu/news/archives/sep06/exercise090806.htm


Different gene-expression predictors of breast cancer agree, UNC study shows

Breast cancer researchers at the University of North Carolina at Chapel Hill have identified a number of activity patterns in the genes of individual tumors that make them biologically different from others. These findings could provide valuable clinical information such as how likely the tumors are to be invasive, how well they might respond to different treatments and how likely they are to recur or spread. Currently, doctors treating patients with breast cancer make treatment decisions and predictions based largely on the location and size of the tumor and if the cancer has spread, or metastasized, to lymph nodes and distant sites of the body. But not all patients who are similar in terms of these clinical indicators get the same benefits from treatment. These new findings could remedy that situation. Such differences in gene activity may be used as biomarkers to identify which treatments can be individually matched.

http://www.unc.edu/news/archives/aug06/nejmperou080706.htm


Cabbage in diet can help fight breast cancer

British scientists have identified a naturally occurring compound, indole-3-carbinol, found in the cruciferous vegetables, belonging to the mustard family, such as cabbage, Brussels sprout, cauliflower and broccoli which can prove to be very effective in the fight against cancer.

http://www.earthtimes.org/articles/show/9370.html


Gene associated with breast cancer may play major role in prostate cancer recurrence

A gene associated with breast cancer also may play a major role in the recurrence of prostate cancer, according to new research from the University of North Carolina at Chapel Hill School of Medicine and UNC Lineberger Comprehensive Cancer Center. The most common cancer in men, prostate cancer can be effectively treated with surgery or radiation when detected early. But advanced prostate cancer is usually treated by drugs or surgery aimed at reducing the level of testosterone and other male hormones, or androgens, that stimulate cancer cell growth. While the disease usually regresses after such treatment, prostate cancer invariably comes back, although it’s not clear why it recurs and progresses.

http://www.unc.edu/news/archives/apr05/her2042005.html


Study links high carbohydrate diet to increased breast cancer risk

Researchers find the risk of developing breast cancer twice as great in Mexican women, for whom carbs represent more than half the daily diet
Carb-conscious dieters may be lowering their risk of breast cancer while they're shedding pounds, based on the findings of research published in this month's edition of the journal Cancer Epidemiology, Biomarkers & Prevention.
In a case-control study of 1,866 women in Mexico, those who derived 57 or more percent of their total energy intake from carbohydrates incurred a risk of breast cancer 2.2 times higher than women with more balanced diets. Dietary patterns in Mexico are characterized by higher consumption of carbohydrates and lower intake of fat and animal protein than those in more affluent western countries.

The team of researchers from the Instituto de Salud Pķblica in Cuernavaca, Mexico, and the Harvard School of Public Health in Boston, suggests that the association between carbohydrates and breast cancer may be related to elevated levels of insulin and insulin-like growth factor binding proteins in the blood.

"Scientists have long suspected that diet was among the factors contributing to breast cancer," said study co-author Walter Willett, M.D., M.P.H., Dr.P.H, the Fredrick John Stare Professor of Epidemiology and Nutrition at the Harvard School of Public Health. "Now, with studies like ours, we are beginning gradually to understand what elements of diet specifically are associated with the disease, and to grasp the chemical and biological processes that contribute to it at the cellular level."

Of all the carbohydrate compounds, sucrose and fructose demonstrated the strongest association with breast cancer risk in the study. Sucrose is derived from sugar cane, sorghum and the sugar beet; it is most commonly found in table sugar and sweetened prepared foods and beverages. Fructose is a component of sucrose and is also found in fruit.

Eating sweets and starches causes a rapid rise in the body's blood sugar levels, which in turn cues the production of insulin and triggers a biological process that ultimately can influence carcinogenesis by causing cells to proliferate.

Insulin and an insulin-like growth factor also may contribute to higher circulating levels of biologically active estrogens, a risk factor for breast cancer in pre-menopausal women. Ninety percent of breast tumors are insulin-receptor positive and over-express the insulin-like growth factor.

The prevalence of type 2 diabetes, often associated with obesity, reflects an underlying insulin resistance in the Mexican population generally. Among urban Mexicans, nearly one-third of women between the ages of 12 and 49 are overweight. Yet when the research team took into account body mass index and other such potentially confounding factors as socioeconomic status, age at first birth, number of children, and family history of breast cancer, the relationship between carbohydrate intake and breast cancer remained the same.

Dietary fat – certainly a contributor to obesity – fared well in the research, showing no significant association with breast cancer risk overall. Willett noted, however, that the intake of polyunsaturated fat by the women in the study group was only about half that of the United States population.

Insoluble fiber intake was associated with lower risk of breast cancer, possibly because fiber may modulate the absorption of carbohydrates and thus affect the glycemic response.

"This study raises important questions about high carbohydrate diets, particularly among populations or individuals prone to insulin resistance. However, one study is not enough to make major changes in diet, and more work on this topic is urgently needed," Willett said.


Study Finds Cardiac Toxicity Rates High With Herceptin Use; Can be Reversed With Treatment

The first study to look at "real world" use of Herceptin in advanced breast cancer patients found a higher incidence of cardiac toxicity - 28 percent of patients treated - than clinical trials of the drug have reported to date, but also concluded that the majority of this heart damage could be reversed with treatment.

The study, published online August 14 in the Journal of Clinical Oncology, concludes that use of Herceptin in patients with metastatic breast cancer "is an acceptable risk," says the study's lead author, Francisco J. Esteva, M.D., Ph.D., an associate professor in the Department of Breast Medical Oncology at The University of Texas M. D. Anderson Cancer Center.

http://www.mdanderson.org/departments/newsroom/
display.cfm?id=5877430A


Benefit of Chemotherapy in Breast Cancer Depends on Estrogen-Receptor Status

When it comes to chemotherapy treatment for women whose breast cancer has spread to their lymph nodes, the estrogen status of their tumors matters, says a team of researchers in the April 12 issue of the Journal of the American Medical Association.

Analyzing data from three clinical trials with a total of 6,644 patients, they determined that chemotherapy works much better in breast cancer that is estrogen receptor-negative (ER-) than many people think, and conversely, doesn't work as well in estrogen receptor-positive (ER+) cancer as believed, says the study's lead author Donald Berry, Ph.D., chair of the Department of Biostatistics and Applied Mathematics at The University of Texas M. D. Anderson Cancer Center.

This conclusion will come as a surprise to many oncologists, Berry says. Women with "node-positive" breast cancer routinely are given chemotherapy, regardless of their tumor type. Women who have ER+ tumors are also given tamoxifen, a drug which inhibits estrogen use by the cancer cells.

http://www.mdanderson.org/departments/newsroom/display.cfm?id=


Curcumin Halts Spread of Breast Cancer in Mice

Curcumin, the main ingredient of turmeric and the compound that gives curry its mustard-yellow color, inhibits metastasis to the lungs of mice with breast cancer, report researchers at The University of Texas M. D. Anderson Cancer Center.

The study, to be published in the Oct. 15 issue of the journal Clinical Cancer Research, reports that the spice appears to shut down a protein active in the spread of breast cancer to a major target for metastasis.

Though the study results are early, researchers found that the nontoxic natural substance not only repelled progression of the disease to the lungs, but also appeared to reverse the effects of paclitaxel (Taxol™), a commonly prescribed chemotherapy for breast cancer that may trigger spread of the disease with use over a long period of time.

Because Taxol is so toxic, it activates a protein that produces an inflammatory response that induces metastasis. Curcumin suppresses this response, making it impossible for the cancer to spread. In fact, researchers found that adding curcumin to Taxol actually enhances its effect. Curcumin breaks down the dose, making the therapy less toxic and just as powerful while delivering the same level of efficacy.

http://www.mdanderson.org/departments/newsroom/
display.cfm?id=40C16848


Gene Found In 90 Percent of Breast Cancers May Be Cancer Vaccine Target

A gene that appears to help regulate normal embryonic development is found at high levels in virtually all forms of breast cancer, according to a new study led by Laszlo Radvanyi, Ph.D., associate professor of breast and melanoma medical oncology at The University of Texas M. D. Anderson Cancer Center.

The finding, published in the Aug. issue of the Proceedings of the National Academy of Sciences and available on-line July 25, shows that the gene, normally made in small amounts in normal breast tissue, somehow becomes over-expressed in breast cancer cells. Researchers hope to use the cancer-specific protein to train the immune system to specifically attack breast cancer cells.

“There is a tremendous need for new molecular targets to treat breast cancer,” Radvanyi says. “There are very few bona fide targets that are exquisitely specific for breast cancer. We believe this is one of them.”

http://www.mdanderson.org/departments/newsroom/
display.cfm?id=38DD9CC6


French Fries, Kids, and Breast Cancer

French fries have appeared in the medical research news once again. This time a large study examined the correlation between breast cancer incidence later in life and a list of 30 foods eaten during the preschool years. Interestingly, the food with the highest correlation to breast cancer was French fries. For one additional serving of French fries per week consumed during ages 3-5 years, the risk of breast cancer increased by 27 percent.

http://www.hpakids.org/holistic-health/articles/169/1/
French-Fries,-Kids,-and-Breast-Cancer


Lymphedema Affects Nearly Half of Breast Cancer Survivors

It's a medical condition without a cure, but lymphedema is barely recognized as a serious health problem and often can go undiagnosed. This could change thanks to findings from a long-term study at the University of Missouri-Columbia's Sinclair School of Nursing. Lymphedema is caused by a compromised lymphatic system. This can occur after breast cancer surgery because of possible damage to the lymphatic drainage system. The condition causes serious swelling in the extremities due to lymph fluid accumulation. In addition to numerous physical effects, lymphedema also can result in psychological distress because normal, daily activities become difficult.

http://munews.missouri.edu/NewsBureauSingleNews.cfm?newsid=8923


Trial adds new weapon in war on breast cancer

Initial Results of the five-year Study of Tamoxifen and Raloxifene, or STAR, released this week revealed the osteoporosis drug raloxifene has been proven to be as effective as tamoxifen in preventing invasive breast cancer. Vanderbilt-Ingram Cancer Center was the only regional participant in the study, one of the largest prevention trials ever conducted. Initial results show that the drug raloxifene, currently used to prevent and treat osteoporosis in postmenopausal women, works as well — with fewer side effects — as tamoxifen in reducing breast cancer risk for postmenopausal women at increased risk of the disease.

http://www.mc.vanderbilt.edu/reporter/index.html?ID=4682


Delivering chemotherapy in a gel may fight breast cancer and help to reduce breast deformity

Women who undergo surgery for breast cancer followed by radiation therapy often experience breast deformities that can only be corrected through reconstructive surgery. Researchers at the McGowan Institute for Regenerative Medicine, in collaboration with bioengineers at Carnegie Mellon University, have developed a polymer-based therapy for breast cancer that could serve as an artificial tissue filler after surgery and a clinically effective therapy.

http://newsbureau.upmc.com/UPCI/ChemotherapyGel.htm


Clues to breast cancer hidden inside stem cells

Stem cells and how to boost them is hot on the research agenda. But stopping them could be critical too, as evidence implicating stem cells in cancer is mounting. In the human breast, up to 20 per cent of all tumours are now suspected to originate in stem cells. Now scientists from the Icelandic Cancer Society and the Faculty of Medicine, University of Iceland have grown three-dimensional breast cell cultures to reveal unexpected subtleties about these stem cells that could explain why they spawn malignancies. These stem cells, Valgardur Sigurdsson remarked during the recent EuroSTELLS Conference in Venice, Italy, could become targets for cancer treatment and lead to new therapies that wipe out cancer at its source. The hope is that they might also become useful tools to test new drugs.

http://www.esf.org/esf_pressarea_page.php?language=
0&section=6&year=2006&newsrelease=109


Gene Profile to Help Decide on Breast Cancer Treatment

In 25 to 30 percent of breast cancer patients, tumors regress completely under chemo-therapy. For sufferers and clinicians alike it would be helpful to have indicators show-ing in advance who will profit from this often stressful treatment. Scientists of the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) and the University Women’s Hospital in Heidelberg have now identified a specific gene activity profile which characterizes those tumors that respond by complete regression to a special treatment regimen.

In breast cancer patients, complete tumor regression in the course of chemotherapy is a fa-vorable prognostic factor. If the treatment is started prior to surgical removal of the tumor, doctors can also observe whether the tumor responds by regression as hoped for. However, not all patients benefit equally from chemotherapy: Depending on the treatment regimen, no more tumor cells are found in tissue examinations of 25 to 30 percent of patients after com-pletion of the prescribed treatment cycles. The remaining sufferers do not or only partially respond to the drugs.

An innovative chemotherapy regimen for breast cancer is a combination of gemcitabine, do-cetaxel and epirubicin. Clinicians and scientists of the German Cancer Research Center and the Heidelberg University Women’s Hospital have developed a test to predict in which pa-tients this drug combination will lead to a complete elimination of tumor cells in the breast. The test is performed using biopsy material obtained from cancerous knots. One hundred breast cancer patients whose tumors had not yet started metastasizing were included in the study.

Using a gene chip representing 21.139 human genes, the researchers identified a specific pattern of gene activities in the cancer cells of a group of patients. This activity profile is characteristic of those tumors that are completely eliminated by the triple therapy. In a sec-ond group of affected women, the scientists subsequently showed that the success of a triple therapy can be predicted using this activity pattern.

http://www.dkfz.de/en/presse/pressemitteilungen/
2006/dkfz_pm_06_28_e.php


Twijfels over preventieve rol soja bij borstkanker

Johns Hopkins and Georgetown University researchers conducted a meta-analysis of 18 epidemiologic studies revealing that women who eat soy products may have a slightly lower risk of developing breast cancer. But the researchers quickly add that inconsistencies and limitations among the studies raise doubt about the potential benefit, and warn women that high-dose supplements could do more harm than good.

http://www.hopkinskimmelcancercenter.org/news/index.cfm?
documentid=771&newstype=News%20Releases&action=showthisitem


Deodorant en borstkanker

Ik roep al een jaar om uit te kijken voor deodorants met aluminium zouten op mijn voorpagina maar krijg nu toch wat onverwachte bijval:

Kan deodorant de kans op borstkanker vergroten?

Wetenschappers geloven dat aluminium zouten in deodoranten de kans op borstkanker kunnen verhogen maar vinden het wel wenselijk dat deze theorie verder wordt onderzocht. Volgens een artikel in de komende april uitgave van het Journal of Applied Toxicology kunnen chemicaliŽn die het het hormoon oestrogeen nabootsen de kans op borstkanker vergroten. Verder komt er steeds meer bewijs dat deze zouten door de huid heendringen en in het lichaam terechtkomen en daar oestrogeen kunnen nabootsen.

http://www.forbes.com/lifestyle/health/feeds/hscout/2006/03/06/l

Ik heb nog even verder gespit en ook een artikel gevonden over planten die voor hetzelfde probleem kunnen zorgen. Met name patiŽnten met verhoogd risico op kanker moeten dus voorzichtig zijn met deze planten.

Researchers have found that several botanicals can mimic the action of the female hormone estrogen -- a potentially dangerous situation for women with, or at risk for, cancers such as breast cancer or cancer of the uterus that grow in response to female hormones.

http://www.webmd.com/content/article/24/1825_50376

Verder kunnen chemische oestrogenen zorgen voor een aandoening "Dysmenorrhea" die te behandelen is door het Progesterone level te verhogen: Deze aandoening zorgt bij vrouwen voor pijnlijke menstruele krampen.

http://www.nodysmenorrhea.com/


90% van kankerpatiŽnten zijn niet op de hoogte van anti-angiogenesis

De makers van het kanker medicijn Avastin claimen dat het grootste deel van de kankerpatiŽnten niet op de hoogte is van de zogenaamde anti-angiongenesis therapie die al meer dan 1 jaar beschikbaar is. Deze behandeling zorgt ervoor dat de bloedtoevoer van de tumor wordt afgesneden waardoor de tumor niet verder kan groeien. De grootste winsten zijn te behalen bij darmkanker, borstkanker en non-small cell longkanker. Het onderzoek stelt dat zeker de mensen die niet tevreden zijn over de mogelijkheden van chemotherapie op de hoogte moeten worden gehouden van nieuwe mogelijkheden zoals deze vorm van kankerbehandeling.

Meer info


Mammografie niet altijd zonder risico's

Het preventief controlen op borstkanker is niet geheel zonder risico's doordat men juist door het gebruik van gamma stralen ook kanker kan gaan ontwikkelen. Dit verhaal is in het Engels maar toch zeer de moeite waard. Lijkt een beetje op de bijwerkingen van een chemotherapie waarbij het immuunsysteem (met name de voorraad anti-oxydanten) flink te leiden heeft met als gevolg een zeer verzwakt immuunsysteem met alle gevolgen van dien.

However, there is growing evidence that mammograms which, like any x-ray, involve zapping the patient with radiation can be positively harmful and even cause the disease they are intended to detect. A Canadian study, which has yet to be published in full, seems set to confirm the findings of earlier research which clearly suggests that you are more likely to die from cancer if you undergo screening than if you don't.

The Canadian study, using the National Breast Cancer Screening Trial, is examining the effect of mammography on women under 50. Data released so far suggests that women whose cancer was detected through mammograms have a shorter life expectancy than those who used self examination alone.

Such concerns are far from new. As long ago as the early 1980s, the late Dr Robert Mendelsohn, in Male Practice, How Doctors Manipulate Women (Contemporary Books, Chicago, 1982), wrote: "I have been warning for years that annual mammographic screening of women without symptoms may produce more cancer than it detects." Mendelsohn quoted Dr C Bailar III, editor in chief of the Journal of the National Cancer Institute, as making the same point in a 1975 report. "His conclusion was supported by numerous studies, which suggested that accumulated x-ray doses in excess of 100 rads over 10 to 15 years may induce cancer of the breast," said Mendelsohn.

Klik hier voor het volledige artikel


Omega 6 vetzuren aanjager van borst en prostaatkanker

Even schrikken? Uit recent onderzoek door Dr Millie Hughes-Fulford (San Francisco VA Medical Center) blijkt dat een zuur dat voorkomt in Omega 6 vetzuren er voor zorgt dat prostaatkanker cellen twee keer zo snel groeien onder laboratorium omstandigheden. Een Spaans team heeft deze link al eerder gelegd bij borstkanker, ook daar was versnelde groei te zien onder invloed van omega 6. Omega 6 zit oa in maisolie en de oliŽn die bakkerijen in hun produkten gebruiken. Het probleem is ontstaan doordat de verhouding omega 3 en 6 volledig verstoord zijn in het moderne dieet. Zestig jaar geleden was de verhouding omega 3 tot omega 6, 2:1 terwijl dit nu 2:50 !!!! Dus de inname van omega 6 is vervijftigvoudigd. Omega 3 zit voornamelijk in lijnzaadolie en vette vis. De testen zullen worden voortgezet op dieren.

Dit zou ook de stijging verklaren van prostaatkanker in de VS. In Japan waar veel soja en vette vis wordt gegeten komt prostaatkanker weinig voor terwijl het in BelgiŽ de tweede oorzaak van sterfte is.

De antioxydant lupeol (aardbeien, mango's en vijgen) zorgt er juist weer voor dat prostaatkankercellen worden afgebroken, dit was al eerder ontdekt bij alvleesklier kanker door Professor Hasan Mukhtar (University of Wisconsin )

Volgens studies in Israel en Amerika hebben nu ook aangetoond dat granaatappel  sap tot celdood bij borstkankercellen kon leiden maar ook een remmende invloed op prostaatkankercellen kan hebben waardoor ziekte vertraagd kan worden. De vrucht blijkt zelfs een krachtiger antioxidant te zijn dan groene thee of rode wijn.

Ook blijkt uit Israelisch onderzoek dat een plant uit Peru, de Rode Maca (Lepidium meyenii) ervoor kan zorgen dat de prostaat kleiner blijft en dus minder kans op kanker.

http://www.e-gezondheid.be/nl//Prostaatkanker_er_hoop_
Japan-12283-263-art.htm

http://www.nutraingredients-usa.com/news/
http://www.nutraingredients-usa.com/news/ng.asp?n=64851
http://www.annieappleseedproject.org/inofapceldea1.html
http://www.rbej.com/content/3/1/5


Genome Code Cracked for Breast and Colon Cancers

Johns Hopkins Kimmel Cancer Center scientists have completed the first draft of the genetic code for breast and colon cancers. Their report, published online in the September 7 issue of Science Express, identifies close to 200 mutated genes, now linked to these cancers, most of which were not previously recognized as associated with tumor initiation, growth, spread or control. “Just as sequencing the human genome laid the groundwork for subsequent research in genetics, these data lay the foundation for decades of research on colon and breast cancers,” says Victor Velculescu, M.D., Ph.D., assistant professor of oncology at the Johns Hopkins Kimmel Cancer Center.

http://www.hopkinskimmelcancercenter.org/news/index.cfm?
816&newstype=News%20Releases&action=showthisitem


Order of Chemotherapy, Radiation Has No Effect on Breast Cancer Survival

For women who have had surgery for early breast cancer, it may not matter whether they receive follow-up chemotherapy before, after or during radiation therapy, according to a new review of studies. A woman’s chances of survival or seeing the cancer return are similar in all three cases, if radiation therapy and chemotherapy begin within seven months after surgery, the review concludes. However, the studies suggest that certain toxic side effects in the blood and esophagus — common in chemotherapy and radiation patients — may be up to 44 percent more likely when the two therapies are delivered at the same time, said Dr. Brigid Hickey and colleagues at the Southern Zone Radiation Oncology Service in Brisbane, Australia.

http://www.hbns.org/getDocument.cfm?documentID=1384


Stem cells in regeneration of breast tissue in Cancer patients

The American scientists have devised a technique that could put an end to reconstructive surgery for women recovering from breast cancer. It is expected that the stem cells derived the patient’s own fat would help in regeneration of breast tissue.

http://www.medindia.net/news/view_news_main.asp?x=15495


Chemo drugs cause cognitive decline in breast cancer patients

Chemobrain is a condition of cognitive decline experienced by several cancer patients receiving chemotherapy. This was confirmed by a recent study conducted on the effect of chemotherapy on cognitive functions in mice.

http://www.medindia.net/news/view_news_main.asp?x=15466


Whole wheat may prevent breast cancer in offspring

The daughters of rats that feast on whole wheat during pregnancy are less likely to develop breast cancer, a new study shows.

http://today.reuters.com/news/articlenews.aspx?type=
healthNews&storyID=2006-11-03


Gene May Help Spur Breast Cancer's Spread

Multiple copies of a gene called uPAR are associated with the spread of early-stage breast cancer, U.S. researchers report. The gene offers a promising target for drugs to slow or halt the progression of the disease, says a team from the University of Texas Southwestern Medical Center at Dallas.

http://www.14wfie.com/Global/story.asp?S=5632200&nav=3w6r


Dietary Vitamin E derivative may be effective for treating and preventing breast cancer

Researchers from the Arizona Cancer Center have identified a chemically altered form of Vitamin E that demonstrates anticancer properties in mice. Emmanuel T. Akporiaye, Ph.D,, and Tobias Hahn, Ph.D, Department of Immunobiology, and their colleagues from the Department of Chemistry, College of Pharmacy, and BIO5 Institute for Collaborative Bioresearch, created a fat-soluble Vitamin E derivative and incorporated it into the diet of mice with mammary cancer. Mice eating the Vitamin E-enriched “chow” showed reduction of tumor volume, and an even greater effect was seen when the chow was eaten as a cancer preventive. This is the first study to demonstrate the ability of this synthetic compound to prevent and treat tumors when given as a dietary supplement.

http://www.azcc.arizona.edu/docs/2006%20press%20releases/
Vit%20E_Mouse%20food.pdf


Video - Inflammatory Breast Cancer

More women are beating breast cancer than ever before. That's thanks to better treatments and early detection. Mammography is a pretty good screening tool that can pick up cancer early, while it's still curable with surgery. But there is a type of breast cancer that often doesn't show up on mammograms. It's called inflammatory breast cancer. It strikes fast and spreads quickly. But IBC can be stopped if you know the signs and symptoms.

http://www.mayo.edu/webcasts/ram/061101edge.wvx


Dietary fat may not raise breast cancer odds

Contrary to some earlier research, a large U.S. study finds no evidence that a high-fat diet raises older women's risk of breast cancer.

http://today.reuters.co.uk/news/articlenews.aspx?
type=healthNews&storyID=2006-11-24


Teunisbloem olie remt borstkanker gen

Gamma-linolenic acid (GLA), one of the fats in evening primrose oil and several other plant oils, inhibits action of Her-2/neu, a cancer gene that is responsible for almost 30 per cent of all breast cancers, reported US researchers yesterday.

The team from Northwestern University also found that when they treated breast cancer cells that overexpressed Her-2/neu with GLA there was a 30- to 40-fold increased response in the cells to the drug Herceptin (trastuzumab), a commonly used treatment for this cancer.

http://nutraingredients.com/news-by-health/news.asp?id
=63664&idCat=120&k=primrose-oil-fatty


Onderzoek naar effect MRT straling op borstkanker cellen

In-Vitro Studies Show MRT Anti-Cancer (Human Breast Cancer) Properties

Foundation for Jacobson Resonance (FJR) -- Experimental in-vitro studies at the College of Veterinary Medicine, Mississippi State University, have revealed anti-cancer properties of MRT, with select
field-schedules, in human mammary carcinoma cell populations.

Foundation for Jacobson Resonance (FJR) -- Experimental in-vitro studies at the College of Veterinary Medicine, Mississippi State University, have revealed anti-cancer properties of MRT, with select field-schedules, in human mammary carcinoma cell populations.

Ten million times weaker than the earth’s steady magnetic field, millions of times weaker than those magnetic fields emitted by power lines, cellular telephones and computers, these fields are apparently
physiologic. Now, we have evidence that they do play a vital role in the structure and function of the state of well being in humans. Three energy field schedules (MRT signals) utilizing the Jacobson Resonator,
consistently suppressed the proliferation rate/viability of neoplastic (cancer) cells in-vitro.

Subsequent studies led by Principal Investigator Dr. Cody Coyne at Mississippi State University, have detected a range of biological proteins -- produced by breast cancer cell types -- have had their profiles
altered following exposure to the same schedules used in the gene studies, referenced above.

Dr. Coyne states: “Investigations have identified membrane associated complexes that are expressed at elevated or decreased levels in MCF-7 populations following exposure to specific multi-frequency pico-Tesla electromagnetic energy field schedules. Investigations have also detected several mRNA sequences that are expressed in populations of MCF-7 human mammary carcinoma cells following exposure to the same schedules that consistently suppressed the proliferation rate/viability of MCF-7 cell populations.” It is our intent to publish these experimental findings in the near future.

Dr. Jacobson offers: “We look upon these findings as critically important. Indeed, we have identified genes and proteins that are probably involved in suppressing growth and viability of human breast cancer cells that can be regulated non-invasively. Furthermore, the genes and proteins identified may serve as “targets” that can function as templates for the design of new chemotherapeutic agents, and MRT may potentially serve as a viable adjunctive modality to conventional chemotherapeutic agents. And. finally, MRT instrumentation can be applied as a research tool for further scientific discovery as we seek to palliate human suffering.”

For further information please contact Harvey Grossman, Founder & President of the Foundation for Jacobson Resonance at 1.877.439.0514 in North America, and at 561.208.1775 from outside North
America. For charitable contributions only, call 561.208.1775


Ginseng and breastcancer

We evaluated the anticancer effect of a range of ginseng compounds in varying doses by adding these compounds to the media in which the breast cancer cells were grown. When the cancer cells were exposed to the ginsenosides in a six-day assay, none of the ginsenosides enhanced the growth of the cells, but the crude fraction we have designated as PQe not only inhibited proliferation of the cancer cells at all doses but actually caused significant tumor cell death when administered at high doses. In a ten-day assay, one ginsenoside (Rc) enhanced the proliferation of the cancer cells, but all other ginsenosides were either neutral or inhibitory. Again, PQe had the greatest inhibitory effect: after 10 days, the number of cancer cells had been reduced by 98% compared to control cell cultures.

http://lpi.oregonstate.edu/s-s00/ginseng.html


Primate study shows soy does not increase breast
cancer risk

A study published in the January 15 2006 issue of the journal Cancer Research concluded that the estrogenic compounds that occur in soy do not increase breast cancer risk and may even help protect some women from the disease. While population studies have found that women whose diets provide high amounts of soy have a lower incidence of breast cancer, soy isoflavones have been found to stimulate the growth of breast cancer cells in culture and in mice. Lead researcher Charles E. Wood, DVM, PhD, of Wake Forest University Baptist Medical Center remarked, "Our study sought to make sense of these seemingly contradictory data. Our hypothesis was that estrogen levels in the body may influence the effects of soy isoflavones."

http://www.lef.org/whatshot/index.html#psss


Breast Brachytherapy

Breast tumors are often treated with a combination of tumor removal followed by external beam radiotherapy to the whole breast. This has been found in several studies to result in the same cure rate as total breast removal. Sadly, only one third or so of women choose to keep their breast. One of the reasons for this low number may be that the external radiotherapy can take as long as 7 weeks to give, and this can be too much time away from home or work for some women.
Since 1998, Cancer Treatment Centers of America has had a treatment program which uses 5 days of partial breast brachytherapy (temporary radiation implant) instead of 5 - 7 weeks of external beam radiotherapy. This shorter time period is a great benefit to all patients, but especially working women, those who live far away from a radiation treatment center, and those who just want to get the treatment over with as quickly as possible.

The brachytherapy procedure involves placing some flexible plastic catheters (tiny tubes) into the breast. The procedure is performed by a board-certified radiation oncologist (Dr. Kelly or Dr. Flynn), and is done under ultrasound guidance. Nine times over the following 5 days, the catheters are briefly connected to our high-dose-rate brachytherapy machine for an internal radiation treatment through the catheters. These treatments take about 15 minutes each and are painless. On Friday, the catheters are easily removed, and you will be able to go home on the same day. During the 5 days of treatment you will be an out-patient and may stay in a guest room in the building. You will not be radioactive, and can do most of your usual activities during that period. We have nutrition classes and other activities available during the week.

Meer hier

Brachytherapie ook in Nederland? Kijk hier


Artificial Light at Night Stimulates Breast Cancer Growth in Laboratory Mice

Results from a new study in laboratory mice show that nighttime exposure to artificial light stimulated the growth of human breast tumors by suppressing the levels of a key hormone called melatonin. The study also showed that extended periods of nighttime darkness greatly slowed the growth of these tumors.

The study results might explain why female night shift workers have a higher rate of breast cancer. It also offers a promising new explanation for the epidemic rise in breast cancer incidence in industrialized countries like the United States.

The National Cancer Institute and the National Institute of Environmental Health Sciences, agencies of the federal National Institutes of Health, provided funding to researchers at the Bassett Research Institute of the Mary Imogene Bassett Hospital in Cooperstown, New York and The Thomas Jefferson University in Philadelphia, Pa. The results are published in the December 1, 2005 issue of the scientific journal Cancer Research.

"This is the first experimental evidence that artificial light plays an integral role in the growth of human breast cancer," said NIEHS Director David A. Schwartz, M.D. "This finding will enable scientists to develop new strategies for evaluating the effects of light and other environmental factors on cancer growth."

"The risk of developing breast cancer is about five times higher in industrialized nations than it is in underdeveloped countries," said Les Reinlib, Ph.D., a program administrator with the NIEHS' grants division. "These results suggest that the increasing nighttime use of electric lighting, both at home and in the workplace, may be a significant factor."

Previous research showed that artificial light suppresses the brain's production of melatonin, a hormone that helps to regulate a person's sleeping and waking cycles. The new study shows that melatonin also plays a key role in the development of cancerous tumors.

"We know that many tumors are largely dependent on a nutrient called linoleic acid, an essential fatty acid, in order to grow," said David Blask, M.D., Ph.D., a neuroendocrinologist with the Bassett Research Institute and lead author on the study. "Melatonin interferes with the tumor's ability to use linoleic acid as a growth signal, which causes tumor metabolism and growth activity to shut down."

To test this hypothesis, the researchers injected human breast cancer cells into laboratory mice. Once these cells developed into cancerous tumors, the tumors were implanted into female rats where they could continue to grow and develop.

The researchers then took blood samples from 12 healthy, premenopausal volunteers. The samples were collected under three different conditions - during the daytime, during the nighttime following 2 hours of complete darkness, and during the nighttime following 90 minutes of exposure to bright fluorescent light. These blood samples were then pumped directly through the developing tumors.

"The melatonin-rich blood collected from subjects while in total darkness severely slowed the growth of the tumors. "These results are due to a direct effect of the melatonin on the cancer cells," said Blask. "The melatonin is clearly suppressing tumor development and growth."

In contrast, tests with the melatonin-depleted blood from light-exposed subjects stimulated tumor growth. "We observed rapid growth comparable to that seen with administration of daytime blood samples, when tumor activity is particularly high," Blask said.

According to the researchers, melatonin exerts a strong influence on the body's circadian rhythm, an internal biological clock that regulates sleep-wake cycle, body temperature, endocrine functions, and a number of disease processes including heart attack, stroke and asthma. "Evidence is emerging that disruption of one's circadian clock is associated with cancer in humans, and that interference with internal timekeeping can tip the balance in favor of tumor development," said Blask.

"The effects we are seeing are of greatest concern to people who routinely stay in a lighted environment during times when they would prefer to be sleeping," said Mark Rollag, Ph.D., a visiting research scientist at the University of Virginia and one of the study co-authors. "This is because melatonin concentrations are not elevated during a person's normal waking hours."

"If the link between light exposure and cancer risk can be confirmed, it could have an immediate impact on the production and use of artificial lighting in this country," said Blask. "This might include lighting with a wavelength and intensity that does not disrupt melatonin levels and internal timekeeping."

"Day workers who spend their time indoors would benefit from lighting that better mimics sunlight," added Blask. "Companies that employ shift workers could introduce lighting that allows the workers to see without disrupting their circadian and melatonin rhythms."

Source: http://www.niehs.nih.gov


Chinese plant doodt borstkanker cellen die tegen chemotherapie bestand was

Selective toxicity of dihydroartemisinin and holotransferrin toward human breast cancer cells.

Artemisinin becomes cytotoxic in the presence of ferrous iron. Since iron influx is high in cancer cells, artemisinin and its analogs selectively kill cancer cells under conditions that increase intracellular iron concentrations. We report here that after incubation with holotransferrin, which increases the concentration of ferrous iron in cancer cells, dihydroartemisinin, an analog of artemisinin, effectively killed a type of radiation-resistant human breast cancer cell in vitro. The same treatment had considerably less effect on normal human breast cells. Since it is relatively easy to increase the iron content inside cancer cells in vivo, administration of artemisinin-like drugs and intracellular iron-enhancing compounds may be a simple, effective, and economical treatment for cancer.

Singh NP, Lai H. Department of Bioengineering, University of Washington, Seattle 98195-7962, USA. narendra@u.washington.edu.

Life Sci. 2001 Nov 21;70(1):49-56

PMID: 11764006


Borstkanker en verzadigd vet en vlees

Our data suggest that, among women living in Saudi Arabia, a diet that is high in fat predisposes to breast cancer development. In terms of nutrients, this high-risk dietary profile translates to a modest, positive association with total fat intake, saturated fat, and cholesterol. This is in contrast to an earlier study, which has cast doubt on a positive association between dietary fat and breast cancer [4]. However, our findings agree with those of Toniolo et al. [18] and Zaridze et al. [19] who showed a positive association between high dietary fat intake and breast cancer. Also high animal protein intake was significantly associated with breast cancer in our study, which supports the findings of De Stefeni et al. [20] and Levi et al. [21] who showed a positive relationship between high dietary meat consumption and breast cancer. Boyd et al. in their quantitative summary of all papers published up to July 2003 on dietary fat and the risk of breast cancer found intake of saturated fat and meat consumption is associated with an increased risk of breast cancer [22].

High consumption of sugar-rich foods, meat and other animal products rich in saturated fats has been recorded in Saudi Arabia [Khan MA, unpublished report, 1996]. Despite the inconclusive evidence about diet and disease, it is important to educate the population about the possibility of a link between dietary habits and cancer and to encourage them to adopt a diet that is low in calories, saturated fat and meat intake.

http://www.emro.who.int/Publications/EMHJ/1006/Dietary.htm

 

 

 


 


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