Myrica rubra - hayberry

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Myrica rubra - hayberry

Een lezer tipte mij over deze vrucht. Ik vond in de Pubmed 2 studies mbt de bast van deze boom. Deze heeft 2 interessante eigenschappen

  • Kan rol spelen bij de celdood van MCF-7 borstkankercellen
  • Heeft een remmende werking op mannelijke geslachtshormonen

    Tetstosteron 5 alfa reductase is een enzym dat de testosteron productie regelt. Deze bes remt dat enzym, met in dit geval als
    gevolg dat - in de reageerbuis - minder testosteron wordt
    gemaakt. In levende organismen werd gevonden dat het spul
    de activiteit van het mannelijk hormoon remde.


Myrica rubra

Myrica rubra, also called yangmei (Chinese: Pinyin: yángméi), yamamomo (Japanese: yamamomo; kanji: ; katakana: ), Chinese Bayberry, Japanese Bayberry, Red Bayberry, or Chinese strawberry tree (and often mistranslated from Chinese as arbutus) is subtropical tree grown for its sweet crimson to dark purple-red fruit. It is native to eastern Asia, mainly in China, where it has been grown for at least two thousand years, and probably also Japan and Southeast Asia as well. Chinese cultivation is concentrated south of the Yangtze River, where it is of considerable economic importance.

Induction of apoptosis in human breast adenocarcinoma MCF-7 cells by prodelphinidin B-2 3,3'-di-O-gallate from Myrica rubra via Fas-mediated pathway.

Kuo PL, Hsu YL, Lin TC, Lin LT, Lin CC.   Department of Biotechnology, Chia-Nan University of Pharmacy and Science, Tainan, Taiwan.

Myrica rubra Sieb et Zucc. (Myricaceae) is well known as a rich source of tannins. Prodelphinidin B-2 3,3'-di-O-gallate (PB233'OG) is a proanthocyanidin gallate that has been reported to exhibit antioxidant and antiviral activity. In this study, we evaluated the anti-proliferative activity of PB233'OG isolated from the bark of M. rubra in human breast adenocarcinoma MCF-7 cells. To identity the anti-cancer mechanism of PB233'OG, we assayed its effect on apoptosis, cell cycle distribution, and levels of p53, p21/WAF1, Fas/APO-1 receptor and Fas ligand. The results showed that PB233'OG induced apoptosis of MCF-7 cells without mediation of p53 and p21/WAF1. We suggest that Fas/Fas ligand apoptotic system is the main pathway of PB233'OG-mediated apoptosis of MCF-7 cells. Our study reports here for the first time that the activity of the Fas/Fas ligand apoptotic system may participate in the anti-proliferative activity of PB233'OG in MCF-7 cells.

PMID: 15525446 [PubMed - indexed for MEDLINE]  J Pharm Pharmacol. 2004 Nov;56(11):1399-406.

Anti-androgenic activity of Myricae Cortex--isolation of active constituents from bark of Myrica rubra.

Matsuda H, Yamazaki M, Matsuo K, Asanuma Y, Kubo M. Faculty of Pharmaceutical Sciences, Kinki University, Higashiosaka, Osaka, Japan.

The aqueous ethanol extract of Myricae Cortex (bark of Myrica rubra Sieb. et Zucc., Myricaceae) showed in vitro testosterone 5alpha-reductase inhibitory activity and in vivo anti-androgenic activity using growth of flank organ in castrated Syrian hamsters and/or hair regrowth after shaving in testosterone-treated C57Black/6CrSlc mice. Three constituents, myricanone, myricanol, and myricetin were identified as the main active principles.

PMID: 11256481 [PubMed - indexed for MEDLINE]  Biol Pharm Bull. 2001 Mar;24(3):259-63




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