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Groeihormoon IGF-1, de kanker booster?


Deze pagina legt een bom onder zowel de zuivel- als de sojaindustrie want als deze informatie klopt dan zijn deze eiwitten grote aanjagers van kanker.

Volgens Dr John McDougall stimuleren zowel de soja- als koemelk eiwitten de produktie van het menselijke groeihormoon IGF-1. Men weet uit studie dat mensen met een lager niveau IGF-1 in hun bloed minder groeien maar ook langer leven.

Ook bij honden worden kleine honden meestal ouder. Er is op een gegeven moment een studie gedaan naar muizen waarbij het IGF-1 level kunstmatig was verlaagd. De muizen werder 40% ouder en bleven langer jong en gezond.

Uit studies blijkt verder dat IGF-1 de groei van je botten stimuleert (gunstig tijdens de groei) maar ook kankergroei stimuleert. Lange mensen hebben meer kans op darmkanker, borstkanker en worden minder oud. Uit een Engelse studie van 2002 bleek dat vrouwen die veganistisch aten 13% lagere IGF-1 levels hadden dan vegetarische (wel zuivel) of vleesetende vrouwen.

Wat is nu het doel van melk? De mens voeden? Nee, het is bedoeld voor een kalf dat in tijd van 6 maanden van 30 naar 300 kilo moet groeien. En daar zorgt nu juist dat IGF-1 hormoon voor. Wat denk je dat dit bij ons kan veroorzaken naast snelle botgroei ?

Bij een studie van 2004 op 8 jarige jongens blijkt dat 1.5 liter magere melk bij hun de IGF-1 levels verhoogd met maar liefst 19%.

In Nederland werkt de Nederlandse dietÔsten vereniging nauw samen met de zuivelpromotie organisatie, denk je dat die dan zullen gaan zeggen dat zuivel of soja ongezond zou kunnen zijn. Hopelijk gaat men uit eigen gelederen ook eens op onderzoek uit naar zowel de risico's van melk en soja. Voedingcentrum idem, krijgt geld vanuit de overheid en ook vanuit de industrie voor leerstoelen, verwacht je dat die dit gevoelige onderwerp aan zullen snijden?

Met soja heb ik altijd al een dubbel gevoel gehad. Aan de ene kant zegt men dat sojabonen goede voeding zijn maar ze moeten dan wel gefermenteerd zijn zoals tofu en tempeh. Maar wat blijkt nu, als je 40 gram eiwit neemt dan zie je de volgende stijgingen:

Eiwit uit zuivel > 36% stijging IGF-1 in het bloed
Eiwit uit soja   > 69% stijging IGF-1 in het bloed

Ik denk zelf dat zuivel/soja geen kanker veroorzaken maar het wel kunnen aanjagen als er een begin van kanker is. Leef je supergezond en heb je geen genetische aanleg voor kanker dan zal dit probleem misschien minder spelen maar is dit niet het geval dan kan een hoge IGF-1 voor een soort sneeuwbal effect zorgen. Het effect zal sterker zijn bij ouderen omdat die meer cellen met schade (roken, dronken, chemicaliŽn) kunnen hebben.

Ga dus zelf op onderzoek uit en lees de informatie die u kunt vinden. Er is geen arts, voedingsconsulente, specialist die je op deze donkere zijde van melk/soja zal wijzen ben ik bang. Ik zal studies, artikelen etc die ik hierover kan vinden op deze pagina plaatsen. Ik ga voorlopig voor noten/groenteburgers, rijstemelk en zeer beperkt (1-2 keer per week) biologisch vlees/wilde vette vis.

In Amerika is het probleem met de melk nog groter omdat boeren daar rBGH (bovine growth hormone) gebruiken, een genetisch gemanipuleerde versie van IGF als het ware.

Men doet het om de melkproduktie nog verder te stimuleren. Het menselijk lichaam heeft receptoren voor zowel lichaamsvreemd IGF van dieren en rBGH. Ook zijn Nederlandse melkkoeien zo gefokt dat zij een hoge melkopbrengst en dus veel IGF hormoon produceren.

Maar nog iets, ook fluor verhoogt IGF-1 levels. Leuk voor al die mensen die fluor tabletjes moesten slikken van de tandarts. Als voorgerecht fluor pilletjes, dan kwik in je kiezen en als toetje goedkope kronen met palladium. Na zo'n maaltijd krijg je vanzelf (metaal) moeheid.....kan allemaal geen kwaad hoor, jaja.....

Ron


Kanker waarschuwing mbt soja voeding

De Cancer Council of NSW (Australische gezondheidsorganisatie) waarschuwt kanker patiŽnten soja produkten te vermijden omdat zij de groei van tumoren kunnen versnellen. Met name de hormoon-gerelateerde kankers zoals borst- en prostaatkanker.

http://www.news.com.au/sundaymail/story/0,23739,21055803-952,00.html

Meer informatie mbt de rol van soja en zuivel op het menselijke groeihormoon IGF-1

http://www.fonteine.com/groeihormoon_igf1.html


Sojamelk en kinderen

Sojamelk niet zo gezond? Sojamelk mogelijk gevaarlijk? Ik kwam ervaringen tegen van ouders waarvan de kinderen veel te vroeg in de groei waren geraakt, die veel te vroeg in de puberteit waren gekomen. Ik schrok hier echt van, omdat onze dochter ook erg groot is voor haar  leeftijd. Ze zit ver boven de hoogste lijntjes van de groeicurves, en we waren al een aantal keer bij de schoolarts geweest omdat die zich daarover ongerust maakte. Indien de groei niet zou afzwakken zouden we 'er iets aan moeten gaan doen'.

http://www.fonteine.com/sojamelk.html


Dierlijk eiwit en hormoon gerelateerde kanker (prostaat/borst)

Ik heb al een paar keer deze relatie genoemd maar weinig mensen nemen het verhaal helaas niet serieus. Met name bepaalde forums voor bodybuilders (die veel eiwitshakes nemen voor spiergroei) doen het verhaal af als onzin. Ook Atkins aanhangers (veel eiwit/vet) moeten dit maar eens lezen. Nederlandse media zijn pro zuivel en soja dus zullen dit wel weer doodzwijgen.  

Misschien dat deze "eiwit shake experts" eens naar deze nieuwe studie moeten kijken......


Does too much protein in the diet increase cancer risk?

Study shows low-protein, low-calorie dieters have reduced levels of hormone linked to cancer. A great deal of research connects nutrition with cancer risk. Overweight people are at higher risk of developing post-menopausal breast cancer, endometrial cancer, colon cancer, kidney cancer and a certain type of esophageal cancer. Now preliminary findings from researchers at Washington University School of Medicine in St. Louis suggest that eating less protein may help protect against certain cancers that are not directly associated with obesity. The research, published in the December issue of the American Journal of Clinical Nutrition, shows that lean people on a long-term, low-protein, low-calorie diet or participating in regular endurance exercise training have lower levels of plasma growth factors and certain hormones linked to cancer risk.

Fontana and colleagues found significantly lower blood levels of plasma insulin-like growth factor 1 (IGF-1) in the low-protein diet group than in either the equally lean runners or the sedentary people eating a standard Western diet. Past research has linked pre-menopausal breast cancer, prostate cancer and certain types of colon cancer to high levels of IGF-1, a powerful growth factor that promotes cell proliferation. Data from animal studies also suggest that lower IGF-1 levels are associated with maximal lifespan.

"Our findings show that in normal weight people IGF-1 levels are related to protein intake, independent of body weight and fat mass," Fontana says. "I believe our findings suggest that protein intake may be very important in regulating cancer risk."

http://mednews.wustl.edu/news/page/normal/8388.html?emailID=12304

Fontana L, Klein S, Holloszy JO. Long-term low-protein, low-calorie diet and endurance exercise modulat metabolic factors associated with cancer risk. American Journal of Clinical Nutrition, vol. 84; pp. 1456-1462, December 2006.


Dr. McDougall over de Insulin-like Growth Factor 1

John McDougall MD bespreekt hier de kankergroei promotor (groeihormoon) IGF-1. Het niveau IGF-1 in het bloed stijgt door consumptie van zuivel produkten, maar net zo goed door geÔsoleerd soja eiwit (sojamelk). Als je dus zuivel vermijdt vanwege mogelijke rol bij kanker dan moet je dus ook uitkijken voor sojaburgers en sojamelk. Het alternatief is dan rijstmelk of amandelmelk.

http://www.drmcdougall.com/
http://www.drmcdougall.com/misc/2005nl/050100pupushing.htm


Diet Changes May Slow Recurrent Prostate Cancer

When prostate cancer recurs, eating a plant-based diet and reducing stress may help slow progression of the disease, a new study shows.

The researchers investigated whether a plant-based diet might be another way to slow the advance of recurrent prostate cancer, because the typical "Western" diet high in animal protein and low in plant foods has been seen to boost the progression of the disease.

http://www.cancerpage.com/news/article.asp?id=10007


IGF-1 hormone Linked to Higher Risk of Ovarian Cancer

High levels of a protein called insulin-like growth factor (IGF)-I may increase women's risk of developing ovarian cancer before age 55, the results of a new study suggest.

Measuring IGF-I levels is unlikely to be useful as a screening test for ovarian cancer, according to the study's lead author, Dr. Rudolf Kaaks, of the International Agency for Research on Cancer in Lyon, France. However, he told Reuters Health that the discovery of elevated levels of the growth factor in women with ovarian cancer raises the possibility that diet, which can increase IGF-I, may be involved in ovarian cancer.

http://www.cancerpage.com/news/article.asp?id=5089


Saving Yourself from Prostate (or Breast) Cancer

Another mechanism linking dairy products and prostate cancer is a very powerful growth-stimulating hormone, known as insulin-like growth factor-1 (IGF-1). This hormone is increased in the body by the consumption of protein, and especially animal protein. However, dairy products are the worst offenders of all the foods we eat for raising this cancer-promoter.8 They can easily increase the levels in our bodies by 10% from consuming amounts of dairy products commonly recommended to keep our bones strong – and this fact comes from studies paid for by the dairy industry.9,10 On the other hand, vegan men have been found to have a 9% lower level of IGF-1 than men who follow a diet with meat and dairy products.11

http://www.healthylifestyleexpo.com/cancer.htm


Soy - double standards

Soy promoters often operate under a double standard, condemning a substance in milk while praising the same compound when it occurs in soy. One egregious example is that of Insulin-like Growth Factor-1, or IGF-1. You have been very vociferous in your condemnation of rBGH milk because it contains high levels of IGF-1, a compound that has been implicated as causing breast cancer.

However, you are silent when it comes to the IGF-1 levels in soy. When they are found in soy, promoters describe them as a benefit for bones. This is similar to the promotion of fluoride by the dental profession, while ridiculing its serious adverse health effects.

According to findings reported by researchers Arjmandi and Khalil, April 2001, soy increases serum IGF-1 levels. They took 64 healthy men and randomly assigned them to two groups, one that consumed 40 g of milk-based protein a day for three months and the other that took in 40 g of soy-based protein on the same schedule. Urine and blood samples showed that both groups experienced an increase in a substance associated with bone formation known as insulin-like growth factor-1.1

The group consuming soy protein had significantly more of this growth factor, according to Arjmandi. He and Khalil presented their findings at the Experimental Biology 2001 meeting in Orlando. "This is the first study to show that soy may benefit skeletal health in males," Arjmandi is quoted as saying.

It is unbelievable that an increase in IGF-1 levels could ever be interpreted as something "beneficial," as there are over 1900 studies on MEDLINE alone clearly showing the implications of IGF-1 in hormonal cancers. Such is the double standard we fine in health research science.

As you know, IGF-1 is released from the liver in response to growth hormones, etc. They act co-dependently with thyroid hormones on many biochemical activities, especially with thyroid stimulating hormone (TSH).

http://www.westonaprice.org/soy/notmilk.html


Kanker en melk

In melk zitten oestrogenen en deze kunnen vooral borstkanker stimuleren, net zoals de pil dit kan doen. Vooral de Amerikaanse biochemicus professor Colin Campbell waarschuwt voor de gevaren van melk en het verkrijgen van borstkanker. Publicaties in de Lancet (50) wijzen op de relatie tussen het groeihormoon (GH), insulin-like growth factor (IGF-1)in melk en kanker. Bij een verhoging van GH, zoals bij acromegalie bestaat, is een verhoogde kans op borst- en prostaatkanker. Een verhoging van het IGF-1 heeft dezelfde gevaren.

Deze twee stoffen schijnen door de pasteurisatie niet stuk te gaan en de groei van kankercellen te bevorderen. Een onderzoek in 1981 vermeldde al dat melk kanker van prostaat en colon kon veroorzaken.

Dat Nederland de langste vrouwen van de wereld heeft is waarschijnlijk het gevolg van de hoge melkconsumptie. Dit gebeurt nu ook in Japan. Nadat men daar ook melk is gaan drinken zijn de vrouwen gemiddeld 11,5 cm langer en 8,6 kg zwaarder geworden en zijn ze 3 jaar vroeger gaan menstrueren.

http://home.planet.nl/~beunk007/melk.html


Prof Campbell over IGF-1

Dierlijke proteÔnen zijn carcinogeen en bevorderen kanker en doen dit op vele manieren. …ťn manier waarop dit gebeurt is door de productie van bepaalde groeihormonen te stimuleren, een ervan heet IGF1 (Insulin like growth factor 1) de insulineachtige groeifactor 1. Dit hebben we in onze proeven ook kunnen meten. Dus caseÔne veroorzaakt de toename van deze groeihormonen en dat stimuleert de groei van kanker.

Een beetje erg simpel gesteld: maar het hormoon gaat naar de cel en creŽert binnen de cel een soort nieuwe set van factoren om de groei te stimuleren. En dat gebeurt op een nogal complexe wijze maar het belangrijke, zelfs het meest belangrijke, hiervan is dat het gebeurt, dus de IGF1 stimuleert celdeling oftewel de vermenigvuldiging van de cel.

Welk soort kanker kan hier het gevolg van zijn?

Het is zo dat deze bewijzen uit onderzoek bij mensen nu pas geleverd worden, dus dat hogere waarden IGF samenhangen met bijvoorbeeld prostaatkanker en, bij sommige onderzoeken, met borstkanker. En, aangezien alle kankersoorten verband houden met een versnelde celdeling oftewel celgroei, hebben alle kankersoorten deze eigenschap. Concluderend, het groeihormoon die de celgroei stimuleert zal hetzelfde effect hebben op verschillende kankersoorten. Het feit dat we nog geen empirische gegevens hebben voor al deze kankersoorten betekent niet dat het niet bestaat. Alleen al op basis van de fundamentele biologie denk ik te kunnen stellen dat wij dit uiteindelijk in verschillende mate zullen kunnen concluderen voor iedere soort kanker.

http://www2.trosradar.nl/?url=PHP/news/20/1180


Soja: niet zo goed als je denkt

Doordat soja nu vrijwel in talrijke producten wordt verwerkt krijgen veel mensen, die geen speciale sojaproducten kopen, het binnen. Mensen die ook nog veel sojamelk, tofu, tempeh, sojaworstjes- en sojavlees eten, krijgen teveel isoflavonen en dus fyto-oestrogenen binnen.

Fyto-oestrogenen zijn endocriene verstoorders. De fyto-oestrogenen verhogen de kans op borstkanker en verstoring van de schildklier. Omdat de fyto-oestrogenen in poedermelk voorkomt en soja vrijwel al in veel producten voorkomt, ook in babyvoeding, is het schadelijk voor de gezondheid van de baby. De fabrikanten weten er van.

http://www.jankraak-taichitao.nl/content/website.php?hoofdpagina_id=1066


Growth Factor Raises Cancer Risk

High levels of a well-known growth factor significantly increase the risks of colorectal, breast, and prostate cancer, medical researchers have found.

When IGF-1 is added to dishes of cells growing in the laboratory, the cells flourish like flowers blooming in spring. In children, the hormone stimulates bone growth and development of organs such as the heart, liver, and kidneys. But in older people, rapidly proliferating cells increase the opportunity for genetic mutations that may lead to cancer. And once cancer cells begin to form, IGF-1 will promote their growth as well as that of normal cells.

Ma mentions evidence of a connection between colorectal cancer and acromegaly, a condition that causes enlargement of facial features, hands, and feet due to excess secretion of growth hormone. "The rate of colorectal cancer among acromegalics is abnormally high, because their IGF-1 levels can be up to 10-fold higher that those of normal people," she notes.

"The levels of IGF-1 implicated in increased risks for cancer among middle-aged and older nurses and physicians in our studies are not as high as those in acromegalics or abnormally tall people," Giovannucci explains. "Rather they are at the high end of what we would consider a normal range."

IGF-1 is a major determinant of height, and taller people are at higher risk for colorectal, breast, and prostate cancer, according to Ma. "It is possible that people who grow tall, because of higher levels of IGF-1 in childhood and adolescence, have a high risk of cancer in adulthood," Giovannucci points out. "However, someone who retains high levels of the hormone from childhood through middle age might be at even higher risk."

http://www.hno.harvard.edu/gazette/1999/04.22/igf1.story.html


Plasma insulin-like growth factor-I and prostate cancer risk: a prospective study

Reduction of androgen action has been the principal strategy under investigation for prostate cancer prevention. If our results are confirmed, pharmacological approaches to decreasing IGF-I bioactivity may warrant investigation as risk-reduction strategies specifically targeted at men at high risk due to increased IGF-I levels. Partial suppression of the growth hormone (GH)-IGF-I axis by somatostatin analogs or GH-releasing hormone antagonists are two possibilities. Finally, our results raise concern that administration of GH or IGF-I over long periods, as proposed for elderly men to delay the effects of aging, may increase risk of prostate cancer.

http://www.ejnet.org/bgh/igf-1science.html


Hormonal Predictors of Prostate Cancer: A Meta-Analysis

Conclusion: Men with either serum testosterone or IGF-1 levels in upper quartile of the population distribution have an approximately two-fold higher risk for developing prostate cancer.

J Clin Oncol 18:847-853. © 2000 by American Society of Clinical Oncology.

http://www.jco.org/cgi/reprint/18/4/847.pdf


Milk could be link to cancer

Pregnancy may lower a woman's risk of cancer but drinking milk could raise it, researchers reported this week. Both factors, as well as the use of hormone replacement therapy, affect levels of a hormone that may influence the development of some cancers, a team at Brigham and Women's Hospital and Harvard Medical School in Boston found.

http://www.nutraingredients.com/news/ng.asp?id=36262-milk-could-be


Growth hormone, IGF-I and cancer. Less intervention to avoid cancer? More intervention to prevent cancer?

The GH/IGF-I axis has a clearly established role in somatic growth regulation and there is much evidence suggesting that it can play a contributing role in neoplastic
tissue growth; a number of recent epidemiological reports indicate that it may also be an important determinant of cancer incidence.

If the association between IGF-I and risk of breast and prostate cancers is as strong as that of the gonadal steroids, as the recent epidemiological data suggest, then this implies that manipulating IGF-I may also be successful in reducing cancer incidence.

http://joe.endocrinology-journals.org/cgi/reprint/162/3/321.pdf


Ook fluor verhoogt IGF-1

Fluoride may be responsible for increased rates of breast cancer by virtue of another process: Fluoride raises levels of a hormone called insulin-like growth factor (IGF-1). Though useful for a number of metabolic functions, when IGF-1 levels are raised there is an increased risk of cancer. Premenopausal women with the highest levels of IGF-1 in their blood have shown a sevenfold increase in the risk of breast cancer. It is interesting to note that other items in the food chain significantly raise IGF-1 levels. One of them is milk which has been treated with Monsanto's bovine growth hormone, and the other, as you may have guessed, is soy.

http://thyroid.about.com/od/bookssupportresources/a/barbeeinterview_2.htm
http://www.mercola.com/2001/aug/22/igf-1.htm

 

Studies

Fluoride treatment increased serum IGF-1, bone turnover, and bone mass, but not bone strength, in rabbits.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve
&db=PubMed&list_uids=9192519&dopt=Abstract


Toename calcium, eiwit en soja kan tot verhoging
IGF-1 levels leiden

Sequential, randomized trial of a low-fat, high-fiber diet and soy supplementation: effects on circulating IGF-I and its binding proteins in premenopausal women.

The results are compatible with previous data suggesting that increases in dietary calcium, protein and soy, in particular, could increase circulating levels of bioavailable IGF-I.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=
pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids
=15800921&query_hl=5&itool=pubmed_docsum


Studies naar rol IGF-1 bij kanker

Er zijn in Pubmed 3461 studies te vinden mbt IGF-1 en kanker.

Nadat je deze link aan hebt geklikt even bij optie "display" de keuze abstract (samenvatting) kiezen.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&db=
PubMed&term=cancer%20AND%20%28igf1%20OR%20insulin%
20like%20growth%20factor%201%29


IGF-I, IGFBP-3 and breast cancer risk in women: The European Prospective Investigation into Cancer and Nutrition (EPIC).

This study confirms previous findings for an association of serum IGF-I and IGFBP-3 concentrations with breast cancer risk, particularly for women with a later diagnosis of cancer, but it does not support the hypothesis of an involvement of IGF-I in younger women.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&
dopt=AbstractPlus&list_uids=16728585&query_hl=2&itool=pubmed_DocSum


Insulin-like Growth Factor I in Pregnancy and Maternal Risk of Breast Cancer

The study offers further evidence that IGF-I is important in breast cancer. Our findings suggest that the adverse effect of IGF-I on the breast may be stronger before the remodeling of the gland induced by a first pregnancy. (Cancer Epidemiol Biomarkers Prev 2006;15(12):2489-93).

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&
dopt=AbstractPlus&list_uids=17132766&query_hl=2&itool=pubmed_DocSum


Factors associated with circulating levels of insulin-like growth factor-I and insulin-like growth factor binding protein-3 in 740 women at risk for breast cancer.

We conclude that circulating IGF-I levels are higher in women with prior breast cancer compared to unaffected women, and that IGF-I and/or IGFBP-3 levels are influenced by age and by reproductive and hormonal factors. These findings support their putative role as breast cancer risk biomarker.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?itool=abstractplus&db
=pubmed&cmd=Retrieve&dopt=abstractplus&list_uids=15538047


Hormones and Cancer Risk

Professor Tim Key, Cancer Research UK, Cancer Epidemiology Unit, The Radcliffe Infirmary, Oxford

The main hormone-related cancers are those of the breast, prostate, ovary and
endometrium. Of these, the best evidence for a chemoprevention strategy is for
breast cancer, either by blocking the effects of oestradiol (by tamoxifen, raloxifene) or
by reducing circulating levels of oestradiol (using aromatase inhibitors [in postmenopausal women] and LHRH agonists [in pre-menopausal women]). Other
hormones that are linked with an increased risk of breast cancer are insulin-like
growth factor (IGF-1) and progesterone (e.g. in Hormone Replacement Therapy).
High parity and breastfeeding offer protection.

For prostate cancer, the hormonal association is less straightforward. Blood tests
show no difference in blood testosterone levels between men with and without
prostate cancer (compared to a 15% difference in oestrogen in women with breast
cancer). This may possibly be due to the fact that the form of testosterone found in
the prostate (DHT) is 100 times more active than that found in the blood. However,
there may again be a role for IGF-1, as this is 6% higher in men with prostate cancer.
The potential for chemoprevention is being studied in a large US trial of finesteride,
which can prevent active testosterone in the prostate. Other strategies might include
blocking the androgen receptor and reducing IGF-1. For the latter, a dietary strategy
might be considered, although the evidence is restricted to vegan diets, where a 10%
difference is seen.

http://science.cancerresearchuk.org/reps/pdfs/meeting_pbs_1prevresrep.pdf


Diets high in fat and animal protein linked to increased risk of non-Hodgkin's lymphoma

Consuming foods high in animal protein, saturated fat, eggs and dairy leads to an increased risk of developing non-Hodgkin's lymphoma (NHL), a cancer that attacks the lymphatic system, part of the body's immune system, Yale researchers have found.

Published in the American Journal of Epidemiology, the study also showed that diets high in dietary fiber -- tomatoes, broccoli, mixed lettuce salad with vegetables, cauliflower, etc.-- were associated with a reduced risk of NHL.

"An association between dietary intake and NHL is biologically plausible because diets high in protein and fat may lead to altered immunity, resulting in increased risk of NHL," said principal investigator Tongzhang Zheng, M.D., associate professor of epidemiology and environmental health at Yale School of Medicine. "The antioxidants found in vegetables and fruits may result in reduced risk of about 40 percent."

The study was conducted between 1995 and 2001 on 601 Connecticut women between the ages of 21 and 84 diagnosed with varying subtypes of NHL. Using a Food Frequency Questionnaire (FFQ) developed by the Fred Hutchinson Cancer Research Center, each participant was asked to characterize her usual diet in the year prior to being interviewed. The FFQ collects consumption frequency and portion size data for approximately 120 foods and beverages and is periodically updated to reflect U.S. food consumption patterns and major market changes. After completion, the FFQ was sent to the Fred Hutchinson Cancer Research Center for calculating average daily nutrient intakes. The study included a control group of 717 women.

"So far, risk of NHL associated with animal protein and fat intakes has only been investigated in American women, in three studies," said Zheng. "If the association could also be demonstrated in American men, it would provide important information towards understanding the cause of NHL."

http://www.yale.edu/


Insulin-like growth factor I (IGF-I), IGF-binding proteins, and
breast cancer.

In premenopausal women, elevated serum IGF-I and IGFBP-3 are associated with increased breast cancer risk, whereas elevated serum IGFBP-2 is inversely associated with risk of postmenopausal breast cancer.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?itool=abstractplus&db=
pubmed&cmd=Retrieve&dopt=abstractplus&list_uids=12496045


Premenopausal levels of circulating insulin-like growth factor I and the risk of postmenopausal breast cancer

The association between circulating levels of IGF-I and postmenopausal breast cancer risk may be modified by age. Increased levels of circulating IGF-I may be of particular interest in the younger premenopausal women and older postmenopausal women. Age-stratification should be undertaken in larger investigations of IGF-I levels as predictors of postmenopausal breast cancer.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?itool=abstractplus&
db=pubmed&cmd=Retrieve&dopt=abstractplus&list_uids=16161053


IGF-1 en insuline beschermen darmkankercellen tegen celdood

Resistance of cancer cells against apoptosis induced by death factors contributes to the limited efficiency of immune- and drug-induced destruction of tumors. We report here that insulin and insulin-like growth factor-I (IGF-I) fully protect HT29-D4 colon carcinoma cells from IFN-gamma/tumor necrosis factor-alpha (TNF) induced apoptosis.

http://cancerres.aacrjournals.org/cgi/content/full/60/7/2007


A prospective study of serum insulin-like growth factor-I (IGF-I), IGF-II, IGF-binding protein-3 and breast cancer risk

These data are compatible with the hypothesis that premenopausal women with a relatively high circulating concentration of IGF-I and low IGFBP-3 are at an increased risk of developing breast cancer.

http://www.nature.com/bjc/journal/v92/n7/abs/6602471a.html


IGF-1 en prostaatkanker relatie

An early small case-control study Greece (1), as well as a more recent larger case-control study in Sweden (2) also found positive associations between IGF-I concentrations and the risk of prostate cancer.

http://www.sciencemag.org/cgi/reprint/282/5387/199a.pdf

1. C. S. Mantoros et al., Br. J. Cancer 76, 1115 (1997).
2. A. Wolk et al., J. Natl. Cancer Inst. 90, 876 (1998).


Soja marketing onzin.....

Marketers of soy products would like us to believe that Asians have good health because they eat a "soy-based" diet. This simply is not true. In China the daily consumption of soy is about two teaspoons. In Japan it is about two ounces a day. In China they get most of their protein from pork. For the Japanese, it is from fish. In fact, the Japanese eat more eggs than they do soy. They eat more eggs than anyone in the world, followed closely by the Chinese. It is curious that the egg sellers didn't capitalize on this. They could have said, "Be healthy, eat like the Japanese, eat more eggs!"

Soy in Japan is used merely as a side dish or condiment, and the form of soy they consume makes a big difference. They mostly consume fermented soy products like tempeh, miso, and natto. The fermentation process alters soy in such a way that the natural toxins, antinutrients, and goitrogens are neutralized, and the isoflavones are made beneficial-- or at least, less harmful.

http://thyroid.about.com/od/bookssupportresources/a/barbeeinterview_2.htm


Animal-based nutrients linked with higher risk of stomach and esophageal cancers

Yale School of Medicine researchers have found that a diet high in cholesterol, animal protein and vitamin B12 is linked to risk of a specific type of cancer of the stomach and esophagus that has been increasing rapidly.

The researchers also found that plant-based nutrients such as dietary fiber, dietary beta-carotene, folic acid, vitamin C and vitamin B6 were associated with lower risk of these kinds of cancers. They further found that regular use of vitamin C supplements was associated with a 40 percent reduction in the risk of cancer in the middle and lower parts of the stomach.

The rate of a specific type of esophageal and stomach cancer, known as adenocarcinoma of the esophagus and gastric cardia, has increased by 300 percent since the mid-1970s, according to lead author Susan Mayne, associate professor in the Department of Epidemiology and Public Health at Yale School of Medicine, and associate director of the Yale Cancer Center. To identify reasons for this rapid increase, the United States National Cancer Institute launched a large study at three centers, including Yale, the University of Washington and Columbia University.

The researchers interviewed patients throughout Connecticut, New Jersey and western Washington State and compared the nutrient intake of 1,095 people with stomach or esophageal cancer to that of 687 healthy people in a control group. The team also looked at the participants' use of nutrient supplements. Their results are published in the October issue of Cancer Epidemiology, Biomarkers & Prevention.

"We found that many animal-based nutrients found in foods of animal origin are strongly associated with risk of developing these types of cancers and we were able to identify nutrients that presumably would be protective," said Mayne. "We also found that regular users of vitamin C supplements were at significantly lower risk of stomach cancer."

In a separate analysis of these data, the research team found that obesity is strongly linked with risk of these cancers. "The increase in the prevalence of obesity in the United States certainly contributes to the time trends," said Mayne. "Our results suggest that prevention strategies for these cancers should emphasize increased consumption of plant foods, decreased consumption of foods of animal origin with the possible exception of dairy products, and control of obesity."


Higher intake of vegetable protein associated with lower blood pressure levels

People who eat more protein from vegetables tend to have lower blood pressure, according to a new study in the January 9 issue of Archives of Internal Medicine, one of the JAMA/Archives journals.
Most adults have either high blood pressure (hypertension) or prehypertensive blood pressure levels, according to background information in the article. Previous studies have found evidence that meat eaters generally have higher blood pressure than vegetarians. Other research looked directly at the effect of high overall protein intake and found that people with higher total protein intake are likely to have lower blood pressure, the authors report.

Paul Elliott, M.B., Ph.D., from Imperial College London, and colleagues analyzed data from the INTERMAP study, which included 4,680 people (2,359 men and 2,321 women) aged 40 to 59 years from four countries. They measured each participant's systolic and diastolic blood pressure eight times at four visits in a three- to six-week period. Each person wrote down everything they had eaten and drank during the previous 24 hours, including dietary supplements, at each visit. Urine samples were also taken on the first and third examinations.

Judging by their food records and urine samples, those who ate more vegetable protein were more likely to have lower blood pressure than those who ate less vegetable protein. Though the researchers noted a slight association between animal protein and high blood pressure, this link disappeared when they accounted for participants' height and weight. There was no link between total protein intake and blood pressure, in contrast to previous studies.

The researchers are unsure exactly how vegetable proteins might affect blood pressure, but note from their data that amino acids may play a role. Some of these building blocks of protein have been shown to influence blood pressure, and different amino acids were present in diets high in vegetable protein than in those that contained more animal protein. Other dietary components of vegetables, such as magnesium, also may interact with amino acids to lower blood pressure.

"Our results are consistent with current recommendations that a diet high in vegetable products be part of a healthy lifestyle for prevention of high blood pressure and related chronic diseases," the authors write. "Definitive ascertainment of a causal relationship between vegetable protein intake and blood pressure awaits further data from randomized controlled trials, especially regarding the effect of constituent amino acids on blood pressure."


 

 

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