glucosamine en voeding


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Glucosamine


Als je regelmatig de advertenties voor supplementen leest dan zul je regelmatig een supplement tegenkomen met de naam Glucosamine.
Waarom dit supplement zoveel aandacht krijgt blijkt wel uit onderstaande
onderzoeken en artikelen. Lijkt op een medicijn maar is een supplement dat
kan helpen bij gewrichtsproblemen. Uit Portugees onderzoek is ook gebleken
dat glucosamine sulfate kan helpen tegen pijnklachten bij knie artrose.

Verder blijkt het even effectief te zijn als Ibuprofen zonder de nadelen van deze pijnstiller. Zelf heb ik nog een fijne ervaring achter de rug na pijn klachten aan mijn schouder. We hadden nog een setje mooie roze Ibuprofen liggen dus die maar genomen maar kreeg gelijk overal uitslag, leek wel
of ik onder een zonnebank had gelegen. Weer wat geleerd....

Een baanbreker op het gebied van glucosamine is Kris Kuiper die al enige jaren bezig is met de verkoop en promotie in Nederland.

Ron


Supplement dat gewrichten repareert zit farma dwars

,,De farmacie is niet blij glucosamine'', zegt Kris Kuiper. ,,Steeds meer mensen ontdekken het. Vroeg of laat gaan de farmaconcerns dat merken in hun omzet.'' Kris Kuiper is een specialist. Weinig mensen weten zoveel over glucosamine als hij - maar Kuiper verdiept zich ondertussen al jarenlang in het wonderlijke supplement. Glucosamine repareert kapotte gewrichten, en werkt zo krachtig dat het soms eerder aan een medicijn doet denken dan aan een supplement. Tegelijkertijd is het veilig. In proeven op mensen hebben onderzoekers nooit gevaarlijke bijwerkingen kunnen ontdekken. ,,De belangrijkste bijwerking is eigenlijk dat een kleine groep mensen met een allergie voor schaaldiertjes er verkeerd op kan reageren'', zegt Kuiper. ,,Glucosamine wordt gemaakt uit schilden van krabben en garnalen, en in de supplementen kunnen eiwitten zitten waar die groep gevoelig voor is.''

Ga naar het volledige artikel (Ergogenics.org)


Soelaas voor krakende wagens?

Glucosamine is een aminomonosaccharide. Het is een bouwstof voor glycosaminoglycanen en proteo-glycanen die in bijna alle weefsels voorkomen, waaronder kraakbeen. Tevens stimuleert het in vitro de kraakbeencellen tot de synthese van glycosaminoglycanen en proteoglycanen. Glucosamine wordt gebruikt bij artrose, het vermindert de pijn en geeft een geringe functieverbetering van het gewricht. Na een periode van 2 tot 4 weken is glucosamine net zo effectief in pijnverlichting als een laag-gedoseerd NSAID. Het chondroprotectief effect is niet bewezen. Glucosamine wordt ook als voedingssupplement gebruikt.

http://www.pharmaselecta.nl/cgi-perl/show.pl?id=2005091


Glucosamine even effectief als ibruprofen

Glucosamine therapy compared to ibuprofen for joint pain.

Ruane R, Griffiths P. Primary Care and Community Pharmacy,
King's College London.

The conclusion is that glucosamine is effective in relieving joint pain associated with osteoarthritis. Glucosamine's pain-relieving effects may be due to its cartilage-rebuilding properties; these disease-modifying effects are not seen with simple analgesics and are of particular benefit. In practice glucosamine can be used as an alternative to anti-inflammatory drugs and analgesics or as a useful adjunct to standard analgesic therapy.

Source: Br J Community Nurs. 2002 Mar;7(3):148-52


GUIDE RESULTS TAP GLUCOSAMINE SULFATE AS PREFERRED MED FOR THE PAIN OF KNEE OSTEO ARTHRITIS

Medical investigation results indicate that glucosamine sulfate may have more ability to control pain due to knee osteoarthritis than does acetaminophen, according to research presented this week at the American College of Rheumatology Annual Scientific Meeting in San Diego, California.

Glucosamine, which is dispensed as a prescription drug in Europe and available as a dietary supplement in the U.S. , has been suggested to improve cartilage biology and counteract factors contributing to joint degeneration, inflammation and symptoms of osteoarthritis.

On-going randomized, placebo-controlled, double-blind trials are being conducted worldwide to assess the effectiveness of oral glucosamine in combating the discomfort of knee osteoarthritis compared to standard symptomatic medications . U.S. researchers from the National Institutes of Health are utilizing GAIT (the Glucosamine/Chondroitin Arthritis Intervention Trial) to compare nutraceutical glucosamine hydrochloride with the anti-inflammatory celecoxib (Celebrex), dividing the glucosamine into three separate daily doses.

European researchers, employing GUIDE , have been comparing glucosamine sulfate with the typically-recommended acetaminophen which is usually taken in three or four 1000 mg doses. The original prescription formulation of glucosamine sulfate soluble powder used provided higher glucosamine levels in the blood to mirror recent favorable glucosamine trials. (Glucosamine sulfate is a slightly different substance than glucosamine hydrochloride. The formulation used in GUIDE is not comparable to most formulations available in the U.S.)

GUIDE investigators followed 318 patients (88 percent women) with symptomatic knee osteoarthritis. Based on randomized groupings, patients took either oral glucosamine sulfate soluble powder (1500 mg once a day), acetaminophen (1000 mg tablets three times a day), or a placebo over a six-month period. All groups were allowed ibuprofen as needed.

Results showed that both glucosamine sulfate and acetaminophen had greater efficacy than placebo use in reducing pain. However, patients taking glucosamine sulfate appeared to experience more relief than did those on acetaminophen.

“Once-daily 1500 mg oral doses of glucosamine sulfate might be the preferred treatment for symptoms of knee osteoarthritis,” summarizes Gabriel Herrero-Beaumont, MD, Director of the Rheumatology Department, Jiménez Díaz Foundation - CAPIO, Madrid, Spain. “Based on these results, physicians who typically recommended acetaminophen may well find their patients gain more comfort taking glucosamine sulfate.”

The American College of Rheumatology is the professional organization for rheumatologists and health professionals who share a dedication to healing, preventing disability and curing arthritis and related rheumatic and musculoskeletal diseases. For more information on the ACR's annual meeting, see www.rheumatology.org/annual.


Structural and symptomatic efficacy of glucosamine and chondroitin in knee osteoarthritis: a comprehensive meta-analysis.

Richy F, Bruyere O, Ethgen O, Cucherat M, Henrotin Y, Reginster JY.

Faculty of Medicine, Department of Public Health, Public Health and Epidemiology, University of Liege, Liege, Belgium.

Our study demonstrates the structural efficacy of glucosamine and indistinguishable symptomatic efficacies for both compounds. Regarding the relatively sparse data on glucosamine and joint space narrowing and the absence of data on structural effects of chondroitin, further studies are needed to investigate the relationship among time, dose, patient baseline characteristics, and structural efficacy for an accurate, disease-modifying characterization of these 2 compounds.

Source: Pubmed.gov


Immunosuppressive effects of glucosamine.

Ma L, Rudert WA, Harnaha J, Wright M, Machen J, Lakomy R, Qian S, Lu L, Robbins PD, Trucco M, Giannoukakis N.

Department of Surgery, T. E. Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA.

Our data demonstrate that glucosamine suppresses the activation of T-lymphoblasts and dendritic cells in vitro as well as allogeneic mixed leukocyte reactivity in a dose-dependent manner. There was no inherent cellular toxicity involved in the inhibition, and the activity was not reproducible with other amine sugars. More importantly, glucosamine administration prolonged allogeneic cardiac allograft survival in vivo. We conclude that, despite its documented effects on insulin sensitivity, glucosamine possesses immunosuppressive activity and could be beneficial as an immunosuppressive agent.

Full article here


Efficacy of Glucosamine and Chondroitin Sulfate May Depend on Level of Osteoarthritis Pain

In a study published in the New England Journal of Medicinei , the popular dietary supplement combination of glucosamine plus chondroitin sulfate did not provide significant relief from osteoarthritis pain among all participants. However, a smaller subgroup of study participants with moderate-to-severe pain showed significant relief with the combined supplements. This research was funded by the National Center for Complementary and Alternative Medicine (NCCAM) and the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), components of the National Institutes of Health (NIH). Researchers led by rheumatologist Daniel O. Clegg, M.D., of the University of Utah, School of Medicine, Salt Lake City, conducted the 4-year study known as the Glucosamine/chondroitin Arthritis Intervention Trial (GAIT) at 16 sites across the United States.

http://nccam.nih.gov/news/2006/022206.htm


NIH Glucosamine/Chondroitin Arthritis Intervention Trial (GAIT)

GAIT is the first, large-scale, multicenter clinical trial in the United States to test the effects of the dietary supplements glucosamine hydrochloride (glucosamine) and sodium chondroitin sulfate (chondroitin sulfate) for treatment of knee osteoarthritis. The study tested whether glucosamine and chondroitin sulfate used separately or in combination reduced pain in participants with knee osteoarthritis.

http://nccam.nih.gov/research/results/gait/qa.htm


“The New England Journal of Medicine” Reviews the GAIT Study: Glucosamine, Chondroitin Sulfate and the Two in Combination for Painful Knee Osteoarthritis

While “The New England Journal of Medicine” concludes that there is still no resolution for the use of supplements in treating knee osteoarthritis (OA), much of the data coming out of the GAIT study
suggests otherwise.

While “The New England Journal of Medicine” concludes that there is still no resolution for the use of supplements in treating knee osteoarthritis (OA),
much of the data coming out of the GAIT study suggests otherwise.

Out of the 1,583 patients that were randomized, 1,258 (80%) completed the study. In the overall population of all patients with mild to moderate pain (WOMAC Pain 125-300mm), the results, for supplement use, while positive, were not statistically significant.

Even the researchers themselves commented that the study had a number of limitations. The high rate of response to placebo (60.1%) and the relatively mild degree of pain from OA among participants, may
have limited the ability to detect the benefits of the treatments.

However, in the severe pain group (WOMAC 301-400mm) the G+CS combination (79.2%) scored higher than both P (placebo) 54.3% and CE (celecoxib) 69.4%, concluding that the combination of glucosamine and chondroitin sulfate is effective in treating moderate to severe pain in patients with knee OA. Researchers also concluded that in this subgroup of patients with moderate to severe pain the combination therapy significantly decreased knee pain as measured by the OMERACT-OARSI response.

Also reported in “The New England Journal of Medicine” was that treatment with chondroitin sulfate alone was associated with a significant decrease in the incidence of joint swelling and effusion. There was a statistical improvement of joint swelling for the overall population, 28.3% to 12.4% (p=0.01) and celecoxib was from 26.1% to 13.4% (p=0.03).

Doctors treating patients are always concerned about addressing a number of issues. Getting the pain under control is the first step, however, dealing with all the other symptoms such as joint swelling, stiffness and function is just as important. It is a vicious cycle; joint swelling in 90% of patients is caused by joint effusion. Joint effusion is an increase of liquid inside the articular space, which produces pain and functional incapacity. According to Nicholas DiNubile, MD and orthopaedic surgeon, “It’s crucial when treating osteoarthritis to break that cycle and treat the disease. I find that joint supplements are a very effective and risk-free way of doing that and it’s good to have data that supports what I see in my clinical practice everyday.”

While this major clinical trial is not offering conclusive results, it suggests that there is a need for more research. Physicians, however, are more pragmatic. They see the supplements work every day for their patients who are suffering with OA. Jason Theodosakis M.D. has a decade of practical use and two best selling books on the subject. According to Theodosakis, “With any medical intervention, the risk/benefit/cost considerations must also be addressed. Glucosamine/chondroitin have the best safety record of any prescription or over-the-counter oral treatment for OA. The results of the GAIT study exulted the benefits in those who actually needed the most relief and the cost of good quality (pharmaceutical grade) supplements is approximately one dollar a day, a third of the price of the most popular
drug prescribed.”

The selection process for the chondroitin sulfate and glucosamine used in the GAIT study was exhaustive. The study was conducted under pharmaceutical rather than dietary supplement regulations and, as
such, the supplements were held to stringent standards of pharmaceutical manufacturing practices. Bioiberica is the leading manufacturer of pharmaceutical-grade chondroitin sulfate and was selected by the
NIH as the exclusive supplier of chondroitin sulfate for the GAIT study. Its CSb™Bio-Active brand of chondroitin sulfate used in the study is commercially available in the US in Cosamin®DS.

 

 


 


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