Crestor cholestrol verlager


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Crestor - cholesterol verlager


Huisarts Hans van der Linde is een kruistocht begonnen tegen het middel Crestor dat wordt voorgeschreven aan patiŽnten met te hoge cholestrol waardes. Volgens de huisarts uit Capelle aan de IJssel is het middel niet effectief en veilig. Omdat niemand deze kwestie onder de aandacht wil brengen heeft hij deze rol maar op zich genomen.

Van der Linde is geen onbekende klokkenluider in het reguliere circuit, al eerder waren de bedrijven MSD en Bayer aan de beurt. Ook heeft hij meerdere bedrijven aangeklacht voor omkoping van huisartsen en specialisten.

Voor velen misschien een schok maar onlangs las ik in een Amerikaans artikel nog een flink stuk over artsen die 9000 dollar per patiŽnt ontvingen die zij als proefkonijn doorstuurden voor nieuwe medicijnen. Dit soort mensen zijn niet alleen een schande voor hun vak maar moeten hard worden aangepakt want dit heeft niets meer met de geneeskunde te maken.

Ik ben wat gaan spitten en zie dat Hans van der Linde niet alleen staat, in Amerika is men al bezig met claims van slachtoffers richting de makers van Crestor.

Ook het Geneesmiddelenbulletin van het College voor Zorgverzekeringen is het eens met de mening van Hans van der Linde. Ook krijgt hij bijval van Prof. dr. Siep Thomas, hoogleraar huisartsgeneeskunde aan de Erasmus Universiteit in Rotterdam, en dr. K. Hoogenberg, internist, endocrinoloog en vasculair geneeskundige in het Groningse Martini Ziekenhuis. Hoogenberg adviseert patiŽnten die Crestor gebruiken om hun arts om een andere cholesterolverlager te vragen.

Al eerder heeft de fabrikant een middel van de mark moeten halen dat tot ernstige leverschade kon leiden:

http://www.cardiology.nl/cardiology/pages/nieuws/
http://www.bcfi.be/nieuws/artikel.cfm?welk=167

Ook schroomt men geen methodes om de concurrent onderuit te halen:

http://www.trouw.nl/deverdieping/dossiers/article7276.ece/

Ik zal u op de hoogte houden van nieuwe ontwikkelingen.......

Ron


'The Statin Wars'

In de Nederlandse media is weinig te merken over de discussie die momenteel woedt rond de statine Crestor. Podium is het medische tijdschrift The Lancet (Lancet 2003; Lancet 362(9393):1341; Lancet 2004; 363(9427):2189-90; Lancet 2004; 364:135). Het direct voorschrijven van hoge doseringen wordt ten sterkste afgeraden, omdat die ernstige gezondheidsschade op kan leveren. Er wordt geroepen om een onverbiddelijk verbod van het middel. Gaat Crestor de statine van Bayer, het Lipobay/Baycol, achterna?

Schuitemaker GE. 'The Statin Wars'. Ortho 2004; 4:171-173

http://www.orthoeurope.com/ortho_pdf/ortho044statinwars.pdf


Cholesterolverlager onverantwoord voorgeschreven

Artsen gevoelig voor marketing

De cholesterolverlager rosuvastatine (merknaam Crestor) wordt veel voorgeschreven, terwijl er twijfels zijn over de werkzaamheid en de veiligheid van het middel. Verschillende artsen betogen in Medisch Contact dat dit te wijten is aan de intensieve marketing van de fabrikant, AstraZeneca.

http://www.zibb.nl/gezondheidszorg/zoekinzibbdetail/asp


Tuchtcollege veroordeelt farmaceut

Pillenfabrikant AstraZeneca heeft de Geneesmiddelenwet overtreden door artsen 230 euro te betalen voor het bijwonen van een promotiebijeenkomst voor een nieuwe cholesterolverlager. Maar het bedrijf wordt niet bestraft. Dit heeft de Codecommissie Geneesmiddelen, een intern tuchtcollege van de farmaceutische sector, gisteren besloten na een klacht van huisarts H. van der Linde uit Capelle aan den IJssel.

http://www.trouw.nl/deverdieping/dossiers/article7283.ece/


Cholesterolverlager Crestor onder vuur

De relatief nieuwe cholesterolverlager rosuvastatine (merknaam Crestor) ligt onder vuur. „De werkzaamheid is onvoldoende bewezen.” Er is bovendien „een risico op ernstige bijwerkingen bij onjuist voorschrijven.” Er zijn bewezen goede en veilige andere cholesterolverlagers. Toch schrijven veel cardiologen en huisartsen recepten uit voor Crestor. Hoe dat komt? „Effectieve marketing door producent AstraZeneca.”

De kritiek van de hoofdredacteur van het Geneesmiddelenbulletin, drs. D. Bijl, op het farmaceutische bedrijf en op collega’s is niet mals. Hij becijfert dat Crestor in 2004 maar liefst 390.680 keer aan patiŽnten werd voorgeschreven. „En dat terwijl er nog geen enkel onderzoek is gepubliceerd dat harde uitkomsten bevat als het gaat om de werkzaamheid”, aldus Bijl.

http://www.refdag.nl/artikel/1222783/Cholesterolverlager


CRESTOR FOUND TO CAUSE KIDNEY DAMAGE AND POTENTIALLY DEADLY MUSCLE CONDITION CALLED RHABDOMYOLYSIS

Introduction: Crestor is one of the most recent drugs found to have the potential to cause serious injury, and Ashcraft & Gerel, LLP is now undertaking representation of victims of Crestor. Although our offices are located in Maryland (MD), Virginia (VA) and Washington, D.C. (DC), our drug and pharmaceutical practice is national in scope, and our lawyers are handling many drug cases around the country. Therefore, regardless of what state you're in, please complete our inquiry form on this web site or email us so that we can have an attorney from our drug litigation department contact you.

Crestor (rosuvastatin calcium) is a cholesterol reducing drug which is part of a class of pharmaceuticals called "statins." Statins reduce cholesterol by reducing a specific enzyme responsible for the synthesis of cholesterol in the body. Crestor is manufactured by AstraZeneca Pharmaceuticals LP of Wilmington, Delaware and has been linked with multiple side effects, including kidney failure, kidney damage and life-threatening rhabdomyolysis which involves the destruction of muscle tissue. According to the consumer group Public Citizen, which has repeatedly called for a ban on the drug, the rate of reported kidney problems is about 75 times higher with Crestor than with all other drugs in the same class combined. According to Public Citizen’s analysis, there have been 6.4 reports of acute kidney failure or kidney damage for every 1 million Crestor prescriptions filled. Public Citizen recently stated that forty-one (41) patients who took Crestor have developed kidney damage.

Dr. Sidney Wolfe, the head of Public Citizen's Health Research Group, in a letter sent to the Food and Drug Administration (FDA) stated: "It becomes clearer by the day that this drug is uniquely toxic without offering any unique benefit, and that it must be removed from the market.”

Bron:

http://www.ashcraftandgerel.com/crestor_drug_claim_lawyer.html


Do Not Use! Rosuvastatin (Crestor) - A New But More Dangerous Cholesterol Lowering 'Statin' Drug

As we said in our testimony before the advisory committee, a major factor that distinguishes rosuvastatin from the other five statins remaining on the market is the drug's potential to cause kidney toxicity.  In the FDA review documents posted on the agency's web site before the Endocrinologic and Metabolic Drugs Advisory Committee it was noted "In contrast to currently approved statins, rosuvastatin was also associated with renal [kidney] findings not previously reported with other statins."

A number of patients taking primarily the 80 and 40 milligram doses of rosuvastatin had an increased frequency of persistent protein in the urine (proteinuria) and blood in the urine (hematuria), that in some subjects was also associated with another abnormal test result that is an early signal for kidney toxicity known as the serum creatinine level.  The FDA documents pointed out that there were two cases of kidney failure and one case of kidney insufficiency with 80 milligrams of rosuvastatin in which these patients also had experienced both protein and blood in the urine.

http://www.worstpills.org/public/crestor.cfm


Statin Drugs Side Effects and The Misguided War on Cholesterol

In his search of the medical and scientific literature for an explanation for his own statin associated transient global amnesia this former astronaut and retired family doctor reveals to his readers the critical importance of cholesterol for proper brain function and memory and the reasons for the damage statin drugs do to our muscles, nerves and heart and even our personalities.

From his participation in the San Diego College of Medicine statin study to his review of FDA's Medwatch files of adverse drug reports and his email correspondence with thousands of distraught patients the world over, Dr. Graveline is uniquely qualified to discuss the magnitude of the statin side effect problem, the complex and wide ranging role of cholesterol in our bodies and the range of serious and unintended consequences of the misguided war on this vital substance.

http://www.spacedoc.net/index.html


What are the grounds for a Crestor law suit?

If you have developed rhabdomyolysis, kidney damage, myoglobinuria, drug-induced hepatitis or a family member has died from acute renal failure (ARF) or any of the above that could potentially be linked with your regular use of Crestor, you may want to consider a Crestor law suit. As with all cases of negligence and product liability, it is important that you consult an attorney regarding filing a Crestor law suit, in order to obtain compensation. Click any of the panels on the left and right sides of this page to contact a Crestor lawyer now.

http://crestorlawsuit.lawinfo.com/frequently-asked-crestor-questions.html


Agency says U.S. researcher was consultant to Crestor maker

One week after cholesterol-reducing Crestor was approved last year, a top government researcher published a scientific paper praising the medication, but failed to mention he was a consultant to the drug's maker, a watchdog group has charged in a letter to the nation's top health agency.

Dr. Sidney Wolfe, director of Public Citizen's Health Research Group in Washington, D.C., said not only was Dr. H. Bryan Brewer a consultant to AstraZeneca, he led a company-financed symposium during a meeting of the American Heart Association about eight months before the drug's approval. The paper and symposium focused on the drug's benefits, but not its side effects, said Wolfe, who added that favorable drug reports by high-ranking government researchers can sway prescribing habits of physicians.

http://www.bruha.com/pfpc/html/crestor_5.html


Crestor May Pose Risk of Muscle Damage

FDA Issues Warning on Use of Cholesterol Drug, Especially by Asians

The popular new cholesterol-lowering drug Crestor may cause an increased risk of potentially life-threatening muscle damage, especially in people of Asian ancestry, the Food and Drug Administration said yesterday.

In a formal advisory, the agency said the risk is small and was largely identified and understood when the drug was approved in 2003. But because of new post-market studies that underscored the concerns, the agency concluded that the public should be informed and that warnings on the product label should be strengthened.

http://www.washingtonpost.com/wp-dyn/articles/A2787-2005Mar2.html


Crestor's Withdrawal Urged

Cholesterol Drug Has Harmful Side Effects, Letter Alleges

The new cholesterol-lowering drug Crestor has more potentially harmful side effects than similar drugs and should be taken off the market, according to a lengthy correspondence published in today's issue of the journal the Lancet.

The letter, written by Sidney Wolfe of Public Citizen's Health Research Group, said that in its first seven months on the market, Crestor was linked to 18 cases of rhabdomyolysis -- a breakdown of muscle fibers that releases proteins that can severely harm the kidney.

The letter said that the drug has greater risk than other statins without providing greater benefit.

http://www.washingtonpost.com/wp-dyn/articles/A4176-2004Jun24.html


FDA Says Crestor Ad Is Misleading

The FDA "has been very concerned about Crestor since the day it was approved, and we've been watching it very carefully."

(CBS/AP) The Food and Drug Administration is seeking to block an ad touting the safety of the cholesterol drug Crestor, calling the claims misleading.

The agency asked the drug maker, AstraZeneca, to "immediately cease the dissemination" of the ad. AstraZeneca had no immediate response to the request.

"The 'patient safety' print ad makes false or misleading safety claims that minimize the risks associated with Crestor, thereby suggesting that Crestor is safer than has been demonstrated by substantial evidence or substantial clinical experience," the FDA said in a letter dated Tuesday.

http://www.cbsnews.com/stories/2004/12/22/health/main662545.shtml


Meer links

Cholesterol Drugs Actually Cause Heart Disease

http://www.mercola.com/2003/jul/26/cholesterol_drugs.htm

The Truth About Cholesterol-Lowering Drugs (Statins), Cholesterol and Health

http://www.mercola.com/article/statins.htm

http://www.mercola.com/2004/aug/4/crestor1.htm


 

 


 


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