Deodorants veroorzaken toch
borstkanker !! KWF ontkent nog altijd verband
Vrouwen die vaak met goedaardige
knobbeltjes of cysten in hun borsten kampen, hebben meer kans op kanker. Steeds meer
Britse artsen denken dat het regelmatige gebruik van antitranspiratie deodorants leidt tot
deze goedaardige knobbels. Dat blijkt uit Brits onderzoek.
An analysis of these so-called 'benign' breast lumps which has just been published in the
Journal Of Applied Toxicology, shows they contain high levels of aluminium, which is
unlikely to have entered the body through any dietary source.
"Onze" KWF is al jaren bezig om
deze link af te doen als onzin en brengt met haar arrogantie veel vrouwen onnodig in
gevaar. Denk zelf eens logisch na, stoffen die je op je huid smeert worden door het
lichaam opgenomen dus ook metalen en chemicaliën. Of dit nu een deo is, een haarverf of
een zonnebrandcreme is, je huid is het grootste orgaan. Kies voor produkten die je ook zou
kunnen eten zoals kokosolie, amandelolie, zout, olijfolie etc etc. Wordt niet het volgende
borstkankerslachtoffer. Baarmoederhalskanker risico's vallen in het niet bij de kans op
borstkanker.
Ron
Hormonen en borstkanker
Patrik Vankrunkelsven is nog steeds actief
als wetenschapper. Recent publiceerde hij in een internationaal wetenschappelijk
tijdschrift (Breast Cancer Research and Treatment) als eerste auteur een artikel dat
aantoont dat er een verband bestaat tussen het gebruik van hormonen en borstkanker. Jaren
geleden al verwittigde hij voor het te grote gebruik van hormonen. Het goede nieuws is dat
door de daling van het gebruik van hormonen, er ook een daling van het aantal borstkankers
waar te nemen is. Wil dit zeggen dat men nooit hormonen mag nemen? Neen, als vrouwen in de
menopauze echt veel klachten hebben, zoals vapeurs, is het verantwoord om deze klachten te
behandelen met de laagst mogelijke dosis aan hormonen en gedurende een beperkte periode,
liefst niet langer dan twee jaar. Artikel in het internationaal wetenschappelijk
tijdschrift 'Breast Cancer Research and Treatment':
Reduction in hormone replacement
therapy use and declining breast cancer incidence in the Belgian province of Limburg.
Patrik Vankrunkelsven ? Eliane Kellen ?
Daniël Lousbergh ? Edith Cloes ? Lode Op de Beeck ? Christel Faes ? Liesbeth Bruckers ?
Raf Mertens ?Jan W. Coebergh ? Flora E. Van Leeuwen ? Frank Buntinx
Abstract
Breast cancer is the most common femalecancer in Europe, but its incidence and mortality
are rapidlychanging across Europe. The early termination of thewomen’s health
initiative (WHI) trial, after the detection ofan increased breast cancer risk in hormone
replacementtherapy (HRT) users, was followed by strong declines ofHRT use worldwide. We
investigated whether the reductionof HRT sales affected breast cancer incidence in
theBelgian province Limburg. All women registered in theLimburg Cancer Registry with a
diagnosis of invasivebreast cancer diagnosed between 1/1/1996 and 31/12/2005were included
in the study. Data on the use of HRT in thepopulation were obtained from the vendors and
the socialsecurity system. For age-standardization using the directmethod, the European
standard population was taken. In2003 and 2004, the breast cancer incidence rate
decreasedsignificantly as compared to 2002 for women aged between50 and 69 years. This
sudden drop in the incidence intercepteda markedly increasing trend until 2002, but
wasfollowed again by an increase in 2005. Between 2002 and2006, the sales of HRT (about
75% to women aged 50–69 years) were reduced by 41%. Breast cancer incidencewas
maximally related to HRT use in the previous year(R2 = 77%). The decrease of breast cancer
incidence in theBelgian province of Limburg may largely be related to thefall of HRT use
following the early termination of the WHItrial. This suggests that HRT stimulates the
growth of preexisting,clinically latent tumours that may not otherwisebecome clinically
apparent.
P. Vankrunkelsven (&) _ E. Kellen _ F.
Buntinx Department of General Practice, Katholieke Universiteit Leuven, Leuven,
Belgiume-mail: patrik@vankrunkelsven.beDit e-mail adres is beschermd door spambots, u
heeft Javascript nodig om dit onderdeel te kunnen bekijken
D. Lousbergh _ E. Cloes Comprehensive
Cancer Institute Limburg, Universiteit Hasselt, Hasselt, Belgium. L. Op de Beeck
Department of Pathology, Mania hospital, Overpelt, Hasselt, Belgium
C. Faes _ L. Bruckers Interuniversity Institute for Biostatistics and Statistical
Bioinformatics, Universiteit Hasselt, Hasselt, Belgium. R. Mertens Intermutalistisch
Agentschap, Brussel, Belgium. J. W. Coebergh Comprehensive Cancer Center South, Erasmus
University, Rotterdam, The Netherlands. F. E. Van Leeuwen Netherlands Cancer Institute,
Amsterdam, The Netherlands
Breast Cancer Res Treat - DOI
10.1007/s10549-009-0346-9
Bron: www.vankrunkelsven.be
Stof in plastic (BPA) veroorzaakt
borstkanker bij ratten
Low levels of BPA raise breast cancer risk
in rat offspring
For the first time, scientists have shown
that low levels of bisphenol A, even below levels considered safe by the EPA, increase
breast cancer risk in rats exposed through their mother?s breast milk. A first of its kind
study shows that low dose exposure to bisphenol A (BPA) during lactation increases the
chance of breast cancer in rats. Early developmental exposures can have long lasting and
adverse health effects. This is the first study to show that a mother rat’s
exposure to BPA during lactation increases her daughter’s chances of breast tumors.
Rats were used in this study because of the similarity in mammary (breast) gland
development with that of humans. If this study could be extended to humans, it suggests
that current safety standards fail to adequately protect the public. Current standards --
which are being reevaluated -- do not take into account recent findings that pertain to
health effects from very low level exposures of BPA and related endocrine disruptors.
Bisphenol A, or BPA, is a widely-used compound found in polycarbonate plastics and resins
that line food and drink containers. Plastic baby bottles, teething toys and cans that
contain formula can have BPA.
Deze stof zit met name in plastic (baby)
flesjes en speelgoed voor de tanden en komt met name vrij als je het plastic opwarmt. Kies
dus voor veilige glazen flesjes.
Why Mammography is NOT an Effective
Breast Cancer Screen
In the first part of the in-depth article
linked below, Beyond Mammography, Dr. Len Saputo explores the latest findings on the
effectiveness and shortcomings of various detection methods used by the mainstream medical
community, including mammography, clinical breast exams, ultrasound, and to a lesser
extent, magnetic resonance imaging (MRIs) and PET scans.
Widespread human exposure to the chemical
bisphenol A (BPA) has resulted from its use in a diverse array of consumer products.
Research on the potential health effects of BPA has focused on the chemical’s ability
to mimic or block natural estrogen. In animal studies, prenatal exposure to BPA increased
susceptibility to mammary cancer in adulthood. However, studies of adult animals and cell
cultures have had mixed results, and even less certain is how BPA might influence
established breast cancer and its treatment. A new cell culture study is the first to show
that BPA, at concentrations comparable to those found in the general population, reduces
the efficacy of chemotherapy drugs in breast cancer cells, apparently by altering
expression of proteins involved in apoptosis, or programmed cell death
Ik heb bij dit bericht een paar keer met
mijn ogen geknipperd. Zoals ik lees hebben de mensen die minder mammogrammen lieten maken
dus minder borstkanker. Dan denk ik, komt het doordat:
A - de extra straling juist kanker kan
veroorzaken
B - veel borstkankergevallen helemaal geen
kanker zijn
C - de Ryke Hamer theorie klopt, dat het
conflict dat de basis is van borstkanker opgelost is
Verder blijkt uit een eerdere analyse van
het Cochrane instituut dat voor iedere vrouw die je redt er 10 onnodig in gevaar worden
gebracht.
Het wordt nog triester als je weet dat er
gewoon alternatieven zijn voor mammografie......
Ron
Alternatief voor mammografie zonder
de stralingsrisico's !
The world's first radar breast imaging
system developed at Bristol University that could revolutionise the way women are scanned
for breast cancer, is being trialled at North Bristol NHS Trust (NBT). Professor Alan
Preece and Dr Ian Craddock from the University of Bristol have been working for a number
of years to develop a breast-imaging device which uses radio waves and therefore has no
radiation risk unlike conventional mammograms. The team began developing and researching a
prototype around five years ago and have received funding from organisations including the
Engineering and Physical Sciences Research Council (EPSRC), the trustees of the United
Bristol Hospitals and the University of Bristol spin-out company, Micrima Ltd. Dr Ian
Craddock from the University's Department of Electrical and Electronic Engineering, said:
"This new imaging technique works by transmitting radio waves of a very low energy
and detecting reflected signals, it then uses these signals to make a 3D image of the
breast. This is basically the same as any radar system, such as the radars used for air
traffic control at our airports."
Lorraine Day's strijd tegen
borstkanker mbv natuurlijke middelen
Beste Ron
Ik ben een trouwe lezer van je website, en
met veel plezier lees ik de interessante zaken die je aan de orde stelt. Je vroeg om
nieuwe artikelen en links over kanker, en deze wil ik je sturen. Het gaat om een
Amerikaanse arts, Lorraine Day, die helemaal hersteld is van borstkanker door natuurlijke
middelen. Zij weet als geen ander (omdat zij zelf arts is) hoe belastend en desastreus de
"normale" medicijnen zoals chemotherapie en bestraling zijn. Zij wilde deze dus
niet gebruiken. Hoe zij genezen is vertelt zij in deze film! Ik vond de film een
eye-opener.
Hier nog een mooie video over de aanpak van
kanker:
Borstkanker en cosmetica
Een overzicht van ingrediënten in
cosmetica die kankerverwekkend en hormoonverstorend zijn en dus de kans op borstkanker
aanjagen. Je huid is je grootste orgaan, wat je erop smeert wordt gemakkelijk door het
lichaam opgenomen. Mooie slogan: "Je bent een rund als je met cosmetica stunt"
Ik zag ooit een thermografisch filmpje
waarbij de maker uitlegde dat een ontsteking van een kies (bijvoorbeeld wortelpunten) kon
doorslaan naar borstweefsel/borstklieren en daar mogelijk kanker kon bevorderen rondom het
aangetaste weefsel.
In dat verband valt dit wel weer op zijn
plaats:
Ontstekingsremmers verlagen de kans op
borstkanker
En als je weet dat steeds meer onderzoekers
ontstekingen zien als de echte oorzaak van depressies, kanker en hart- en vaatziekten doe
dan je voordeel met deze informatie. En nog iets, teveel omega 6, dus linolzuur
(zonnebloemolie, slaolie etc) en rood vlees (met name varkensvlees) jagen juist
ontstekingen aan en kunnen zelfs de opname van omega 3 blokkeren.
Faktoren die je kans op borstkanker
verhogen:
- Vroege menstruatie (voor 12 jaar)
- Geen kinderen krijgen
- Kinderen nemen na de leeftijd van 30 jaar
- Familiegeschiedenis met borstkanker (genetisch)
- Bestralingen in het borst gedeelte (dus ook mammografie!)
- Hormoontherapiën (HRT) na 5 jaar of langer
- Overgewicht, vetcellen slaan oestrogeen op
Bron: American Cancer Society
Borstkanker en borstsamenstelling
Door de samenstelling van de borst anders
te gaan bestuderen, zou meer informatie kunnen worden verkregen over de kans op het
ontstaan van borstkanker en mogelijkheden om die kans te verkleinen. Gerco Haars komt tot
die conclusie in zijn proefschrift. Vrouwen tussen de 50 en 75 jaar kunnen in Nederland
elke twee jaar een borstfoto (mammogram) laten maken. In hoofdzaak worden die foto’s
beoordeeld op het al dan niet aanwezig zijn van een mogelijke tumor. Op het mammogram zijn
echter ook de hoeveelheid klierweefsel en vetweefsel te meten. Tot nu toe werd vooral de
verhouding tussen die twee weefsels uitgerekend en onderzocht. Het is daardoor al lang
bekend dat het hebben van een hoog percentage klierweefsel in de borst een aanwijzing is
voor een hogere kans op het ontstaan van borstkanker. Het blijkt nu dat de hoeveelheid vet
in de borst ook een rol zou kunnen spelen. Daarom zou het beter kunnen zijn om de
hoeveelheid klierweefsel en vetweefsel apart te onderzoeken, in plaats van hun verhouding.
Als het verband tussen vet en borstkanker kan worden bevestigt, biedt het nieuwe
mogelijkheden voor verder onderzoek naar het ontstaan van borstkanker, maar ook meer
mogelijkheden voor preventie omdat de hoeveelheid vet makkelijker is te beïnvloeden dan
de hoeveelheid klierweefsel. Gerco Haars promoveerde op 9 september aan het UMC Utrecht.
Vroegtijdige detectie zonder
straling - Thermography
Het gebruik van Digital Infrared Imaging
(DII) is gebaseerd op het principe dat metabolische activiteit en bloedcirculatie in zowel
pre-kanker weefsel en het gebied rondom borstkanker in ontwikkeling bijna altijd hoger is
dan in gewoon borstweefsel. Vanwege een continu toenemende behoefte aan voedingstoffen,
kankercellen verhogen de circulatie in hun cellen door bestaande aders open te houden,
inactieve aders te openen en nieuwe te creëren (neoangiogenesis). Dit proces leidt
regelmatig tot een verhoging van de temperatuur op lokale plekken op de borst. DII
gebruikt ultragevoelige medische infrarood camera's en geavanceerde computers om zeer
duidelijke beelden van deze temperatuurvariabelen op te sporen, analyseren en produceren.
Vanwege de hoge gevoeligheid van DII, kunnen deze temperatuurvariabelen één van de meest
vroege tekenen van borstkanker en/ of een pre-kanker staat van de borst, zijn.
Oestrogeen
chemicaliën in cosmetica. Wat je moet weten, van Cornell Universiteit. Wat je meteen al
kan doen: Lees de labels aandachtig. Ingrediënten zijn genoteerd in aflopende orde
gebaseerd op gewicht op alle persoonlijke verzorgingsproducten. Leer en onthoud de namen
van chemische oestrogenen zoals Paraben, Placenta extracten, Benzophenonen. Maak keuzes.
Overweeg om producten te gebruiken die geen chemische oestrogenen bevatten.
Auteur
en dokter William Campbell Douglass bespreekt de problemen die gelinkt zijn met soja
vanwege de eigenschap om het vrouwelijke hormoon, oestrogeen, na te bootsen.
Het onderzoek, dat werd uitgevoerd door de
Deense vestiging van het Britse Cochrane instituut, bevestigt wat
eigenlijk al langer duidelijk was: zelfonderzoek van de borsten leidt op lange termijn
niet tot minder sterfte door borstkanker. Zelfcontrole heeft zelfs nadelen.
Borstkankeronderzoek - de risico's
versus de voordelen
Het Cochrane instituut
is een onafhankelijke wetenschappelijke organisatie die kritisch kijkt naar medische
studies. Uit een analyse van 7 studies gedaan onder 500.000 vrouwen blijkt het volgende:
Van iedere 2000 vrouwen die 10 jaar
lang worden gecontroleeerd wordt er van één vrouw het leven verlengd maar 10 gezonde
vrouwen worden onnodig behandeld voor borstkanker met alle risico's van dien.
De vraag is nu dus of het screenen meer
goed doet dan kwaad....Vrouwen horen op de hoogte te zijn van de mogelijke risico's en
voordelen van onderzoek volgens de onderzoekers.
Conclusies
van de auteur
Screening
wekt de indruk dat het borstkanker sterftecijfers verlaagd. Gebaseerd op alle testen,
wordt het percentage verlaagd met 20%, maar aangezien het effect lager is in de hoogste
kwaliteitstesten, is 15% een meer realistischer schatting. Gebaseerd op het risico niveau
van de vrouwen in deze testen, was de absolute risico verlaging 0,05%. Screening leidt ook
tot onnodige diagnoses en onnodige behandelingen, met gemiddeld 30% toename, of een
absolute risico toename van 0,05%. Dit betekent dat voor elke 2000 vrouwen die gedurende
10 jaar gescreend worden, er één leven verlengt zal worden. Daar tegenover staat dat 10
gezonde vrouwen, die anders geen diagnose zouden krijgen als er geen screening plaats had
gevonden, nu gediagnosticeerd worden met borstkanker en daarom onnodig behandeld zullen
worden. Het is daarom nog niet duidelijk of screening meer goed dan kwaad doet. Vrouwen
die opgeroepen worden voor screening moeten volledig geïnformeerd worden over de voor- en
nadelen van screening.
De
Cochrane Collaboration is een internationale, non-profit en onafhankelijke organisatie die
zich toewijd op het verschaffen van up to date en accurate informatie over de effecten van
de medische zorg die wereldwijd beschikbaar is. Het produceert en ontleedt systematisch de
verslagen van medische interventies en stimuleert de zoektocht naar bewijs zoals klinische
testen en andere studies over interventies. De Cochrane Collaboration is gesticht in 1993
en is vernoemd naar de Britse epidemioloog, Archie Cochrane.
Ik noem al 2.5 jaar als een roepende in de
woestijn de gevaren van verhitting van granen en aardappels boven de 120 graden maar nu is
er dan het eerste bewijs voor een relatie tussen deze stof en borstkanker. Deze stof zit
met name in ontbijtkoek, pepernoten, bruin gebakken chips, bruin gebakken patat etc etc.
Acrylamide in voedsel verhoogt
mogelijk het risico op borstkanker
Acrylamide is a chemical formed when
frying, roasting, grilling or baking carbohydrate-rich foods Acrylamide is een chemische
stof die gevormd wordt wanneer men koolhydraatrijke voedingsmiddelen bakt, roostert, grilt
of frituurt boven een temperatuur van 120°C. Acrylamide wordt daarom dan ook gevonden in
een flink aantal voedingswaren zoals brood, chips, friet en koffie. Roken genereert ook
aanzienlijke hoeveelheden acrylamide.
"Dierproeven hebben aangetoond dat
acrylamide kankerverwekkend is, maar tot voorheen zijn er geen studies geweest die een
link aantoonden tussen acrylamide in voeding en kanker bij mensen. Onze studie is de
eerste epidemiologische studie die biologische beginpunten gebruikt om blootstelling aan
acrylamide te meten. En het is ook de eerste die een positieve relatie tussen acrylamide
en borstkanker meldt," zegt Henrik Frandsen, senior wetenschapper bij de National
Food Institute, Technische Universiteit van Denemarken.
Opnieuw link borstkanker en het
progesteron hormoon
Dus de pil en menopauze
medicatie !
Een link met borstkanker
Onderzoekers tonen link aan tussen
hormoongroei en tumoren.
Veel vrouwen boven de 40 hebben kleine tumoren in hun borsten - meestal zonder dat ze daar
vanaf weten. Deze tumoren groeien normaal gesproken tot 1 millimeter in omvang en stoppen
daarna met zich verder ontwikkelen omdat ze te weinig voedingsstoffen krijgen. Dus hoe en
waarom ontwikkelen andere tumoren zich wel tot kanker? Deze vraag is de stuwende kracht
achter het werk van de biomedische wetenschappelijke onderzoeker Salman Hyder. In het
nummer van 15 oktober van Cancer Research, Hyder en collega's publiceerden hun bevindingen
over progesteron, een hormoon dat voorkomt in anticonceptie en middelen voor de menopauze.
Hun onderzoek toont aan dat progesteron actief betrokken is bij de verdere ontwikkeling
van menselijke borstkanker cellen bij een dierlijk model. Tot voorkort waren zulke
bevindingen beperkt tot dierlijke cellen.
Tumoren stimuleren
Nieuw weefsel dat zich wil ontwikkelen heeft de vorming van nieuwe bloedvaten nodig - een
proces dat angiogenesis genoemd wordt. Tumorcellen kunnen signalen generen, in de vorm van
'groeifactoren' die hen toelaat nieuwe bloedvaten van nabijgelegen weefsel over te nemen.
Hyder bestudeert het mechanisme waardoor deze signalen zich genereren, daarbij focust hij
zich meer specifiek op de vasculaire edotheliale groei factor (VEGF). Hyder - de Thelma P.
Zalk Missouri Professor van Tumor Angiogenisis en een onderzoeker aan de Dalton
Cardiovasculair Onderzoek Centrum - werkt samen met collega Yayun Liang en andere
medewerkers in Mizzou en de Universiteit van Texas Southwestern. De groep heeft aangetoond
hoe progesteron en VEGF op elkaar reageren in bepaalde tumor cellen die een mutantversie
van een proteïne genaamd p53 bevatten. Hyder zegt dat p53 eigenlijk tumoren in normale
gevallen onderdrukt. Echter, sommige vrouwen hebben een mutant p53 dat niet op diezelfde
manier werkt. Bij deze vrouwen, "begint" progesteron VEGF uitbreiding. Anders
gezegd, betekent dit dat progesteron een toename in nieuwe bloedvaten kan bevorderen,
welke op hun beurt, de ontwikkeling van een tumor voeden.
Hormoon therapieën en het dilemma.
Salman Hyder en collega's hebben een link aangetoond tussen progesteron en toename van
borstkanker in menselijke cellen. Vrouwen krijgen progesteron binnen via anticonceptie en
andere medische situaties. Synthetische progesteron, of progestin, wordt ook wel gegeven
in combinatie met oestrogeen als een hormoonvervangende therapie (HRT) om opvliegers,
depressies en andere symptomen van de menopauze te verminderen. Met HRT voorkomt het
progestin zelfs de tumoren die kunnen ontwikkelen wanneer oestrogeen de baarmoeder
stimuleert. Echter, vele medische proeven, waaronder de Million Women Study en een
uitgebreide National Studies of Health, ook wel bekend als de Women's Health Initiative
(WHI), tonen aan dat wanneer progestin over een langere periode wordt ingenomen, dit het
risico op borstkanker met ongeveer 26 procent verhoogt. Daarmee ontstaat er een dilemma
voor vrouwen tijdens de menopauze - of een HRT behandeling met progestin en een verhoogd
risico op borstkanker, of op zoek naar alternatieve hormoontherapie zonder progestin en
verhoog het risico op baarmoederkanker. Hyder zegt dat dit dilemma een grootschalige
discussie op gang gezet heeft. Hij adviseert vrouwen om met hun dokters te overleggen en
daarna een goed geïnformeerde beslissing te nemen over het wel of niet innemen van HRT.
Dokters zullen de familiegeschiedenis, leefwijze en andere factoren evalueren en meenemen
in de overweging.
"Er is weinig twijfel meer dat
progestins de aanmaak van nieuwe bloedvaten kunnen verhogen, wat daarmee tot tumor
ontwikkeling kan leiden," zegt Hyder. "Als er een aanleg voor borstkanker in de
familie is, dan is het zeer aan te raden voor vrouwen om medicamenten met progestins te
vermijden." Nieuwe ontwikkelingen en toekomstige behandelingen die een link aantonen
tussen progesteron en borstkanker in menselijke cellen is een duidelijke stap voorwaarts
en het heeft geleid tot verder onderzoek. Hyder en zijn collega's bestuderen manieren om
tumoren uit te roeien door de VEGF te onderdrukken en bepaalde bloedvaten te doden die
tumoren in ontwikkeling voeden. Natuurlijke, niet-muterende p53 treedt op als een
tumoronderdrukker en corrigeert fouten of roeit mogelijke kankercellen uit wanneer die te
overheersend worden. Zulke middelen scheppen niet alleen mogelijkheden in de behandeling
van borstkanker tumoren, maar ook bij andere vormen van kanker. Hyder en zijn collega's
discussiëren deze mogelijkheden in Cancer Research. "Wanneer we veilige
anti-hormonen of anti-angiogenesis kunnen vinden, dan zouden we wellicht de groei van
tumoren kunnen voorkomen of stopzetten," aldus Hyder.
Producten met cafeïne (o.a. koffie, thee,
cola, energiedranken) zorgen voor gevoelige en knobbelige borsten. Daarom wordt aangeraden
1 week voor de mammografie deze producten niet te consumeren, om onnodige pijn te
voorkomen. Vrouwen die nog menstrueren kunnen het best de mammografie in de eerste helft
van de cyclus laten verrichten, aldus Christian Albring van het beroepsverband van
vrouwenartsen. Duitsland: bericht van ARD -text 2 november 2007
xxx
Mammogrammen verhogen kans op
borstkanker met 250%
An International Agency for Research on
Cancer study showed that chest X-rays may increase women's chances of developing breast
cancer. The study involved 1,600 women with high-risk
BRCA1 and 2 gene mutations. "If confirmed in prospective studies, young women who are
members of families known to have BRCA1 or BRCA2 mutations may wish to consider
alternatives to X-ray, such as MRI," Lead researcher Dr. David Goldgar said....
Researchers say common chemotherapy drugs
too risky for many patients
What if an estimated 100,000 breast cancer
patients got drugs that did nothing to combat their cancer, but put them at risk for heart
failure and leukemia? That is the implication of new
research that was presented in private session at this week's meeting of the American
Society of Clinical Oncology(ASCO) in Chicago.....
· MRI scans found to detect better than
x-rays
· Charities say current screening still effective
Cancer screening programmes are failing to
detect nearly half of the earliest cases of breast cancer according to research which
suggests women's lives could be saved if all were offered hi-tech
MRI scans. The study in the Lancet medical journal found that x-ray based mammograms
detect only 56% of early lesions in high risk women compared with 92% when magnetic
resonance
imaging scans (MRI), more commonly used for brain scans, are used.....
A new study on aspartame conducted by the
Ramazzini Foundation reveals that aspartame causes a dose-dependent increase in cancers
(lymphomas, leukemias and breast cancers) when consumed at levels approaching those
consumed by humans in diet soft drinks.....
Nadat ook ik in mijn omgeving werd
geconfronteerd met "vermoedens van borstkanker", vond ik dat het wel erg
dichtbij was gekomen. De moeder van een Italiaanse vriendin (jong!) overleed eraan; de
vriendin met ook klachten staat onder strenge controle. Hetzelfde met een vriendin in
Nederland...........Onderstaande link is het waard door ALLE VROUWEN gelezen te worden
(...en natuurlijk de mannen niet te vergeten). En geef de link door aan je vriendinnen,
want ieder kan te maken krijgen met borstkanker.
Vrouwen die per dag 1.5 portie rood vlees
eten hebben ten opzichte van vrouwen die drie keer per week rood vlees eten een dubbele
kans op borstkanker volgens een nieuwe analyse van de The Nurses’ Health Study door
onderzoekers van de Harvard Medical School.
Dr Kala Visvanathan ( Johns Hopkins
University) deed onderzoek naar eetpatronen van ruim 300 vrouwen met borstkanker en 300
vrouwen zonder borstkanker. Zij ontdekte dat vrouwen die 2 keer maand gegrild vlees (boven
vlammen) aten 74% meer kans op borstkanker hadden. Door de sterke verhitting ontstaan
namelijk meer kankerverwekkende chemicaliën, de zogenaamde heterocyclic amines.
Met Arimidex langer borstkankervrij
dan met Tamoxifen
Volgens een meta-analyse van 3 belangrijke
studies door Professor Walter Jonat van de Universiteit
in Kiel, Duitsland kunnen vrouwen met borstkanker langer kankervrij blijven door
Tamoxifen te vervangen
door Arimidex.
Over de afgelopen jaren is er een toename
te zien in het aantal gevallen van borstkanker in de westerse wereld. Tegenwoordig krijgt
gemiddeld 1 op de 8 vrouwen borstkanker. In Nederland komt dit neer op ongeveer 10 000
vrouwen per jaar, van wie er ongeveer 3 500 sterven aan de gevolgen ervan. Er zijn
verschillende genetische risicofactoren bekend, zoals het borstkankergen BRCA, maar in het
overgrote deel van de borstkanker gevallen is de oorzaak niet zo duidelijk aan te wijzen.
Er is wel een aantal factoren die het risico op borstkanker kunnen vergroten. Dit zijn
bijvoorbeeld op jonge leeftijd de eerste menstruatie krijgen, op late leeftijd in de
menopauze komen, geen kinderen krijgen of op late leeftijd een eerste kind krijgen, al
eerder borstkanker hebben gehad en ook verschillende levensstijlfactoren kunnen een rol
spelen. Al deze factoren hebben invloed op de hoeveelheid oestrogenen waar een vrouw
gedurende haar leven aan wordt blootgesteld.
Het is borstkankermaand. Denk je aan
borstkanker, dan denkt iedereen automatisch aan vrouwen. Maar ook mannen kunnen
borstkanker krijgen. Het is dan ook vrij zeldzaam, maar dat neemt niet weg dat er meer
voorlichting moet zijn voor mannen die het overkomt. De informatie is nu nog veel te veel
op vrouwen gericht, vindt borstkankerpatient Simon Luites.
Nog niet zwanger geweest ? Dan meer
kans op borstkanker !
Waarom hebben vrouwen zonder kinderen meer
kans op borstkanker? Simpel omdat het weefsel in de borst nog niet de veranderingen heeft
doorgemaakt die normaal tijdens een zwangerschap plaatsvinden. Het weefsel is dan ook
vatbaarder voor kankerverwekkende stoffen. Zo is intussen ook bekend dat het geven van
borstvoeding juist de kans op borstkanker weer verkleint. En doe je dit minimaal 6 maanden
dan ook verbetering van de mentale ontwikkelingen/gedrag van je kind op latere leeftijd
bleek afgelopen week uit
een 16 jarige studie in Australië, minder depressies, minder asociaal en agressief
gedrag.....
Dus je kunt wel nagaan wat de risico's
zijn als je rookt voor je eerste zwangerschap......
Zo is intussen ook bekend dat het geven van
borstvoeding juist de kans op borstkanker weer verkleint. En doe je dit minimaal 6 maanden
dan ook verbetering van de mentale ontwikkelingen/gedrag van je kind op latere leeftijd
bleek afgelopen week uit een 16 jarige studie in Australië, minder depressies, minder
asociaal en agressief gedrag.....
44% meer kans op borstkanker voor
de menopauze door de pil
Uit een nieuwe meta-analyse van 34 studies
in de oktober uitgave van de bekende Mayo Clinic Proceedings mbt de kans op borstkanker
door orale voorbehoedsmiddelen (de pil) blijkt opnieuw dat vrouwen een verhoogde kans op
borstkanker hebben, met name de vrouwen die al voor het eerste kind de pil slikten hebben
meer kans om borstkanker te krijgen voor de menopause. Het percentage is zelfs 44%
De wereldgezondheidsorganisatie zetten al
in 2005 orale voorbehoedsmiddelen op de lijst van klasse 1 kankerverwekkende stoffen. De
onderzoekers geloven dan ook dat artsen hun patiënten hierover moeten inlichten omdat de
patiënt recht op deze informatie heeft.
Oral Contraceptive Use and Breast
Cancer Risk: Current Status
One might have thought that the issue
of whether oral contraceptives (OCs) are associated with breast cancer risk would have
been settled by now, given that these agents were introduced in the early 1960s and more
than 60 case-control and 10 cohort studies, several meta-analyses,- a very
large pooled analysis, and a major monograph have addressed this issue. On the basis of
the accumulated data, the International Agency for Research on Cancer (IARC) classified
oral estrogen-progestogen contraceptives as carcinogenic to humans (group 1 carcinogen) in
2005, which is a higher classification than the 1999 IARC evaluation.
Always a Bitter Pill, Now the Risk of Breast Cancer Makes Oral Contraceptives
Even Harder to Swallow
However, compelling data has emerged
linking the Pill with the rapid increase of breast cancer in the US, with a potential of
class action lawsuits that could eclipse those even of the tobacco industry. Evidence has
been available for several decades linking oral contraceptives with breast cancer in
certain lab animals. According to Chris Kahlenborn, MD, one of the nation’s leading
researchers on the breast cancer/ Pill connection, the evidence of a link in humans is
incontrovertible. His book summarizing his research and findings, BREAST CANCER: Its Link
to Abortion and the Birth Control Pill, was published recently by One More Soul
(www.OMS.com.)
Borstcontrole - mammogram of breast
specific gamma imaging ?
Het kan gebeuren dat je bent gecontroleerd
mbv ultrasound of mammogram op borstkanker en dat je toch zelf een knobbeltje in de borst
ontdekt. Er is nu nog een betere controle mogelijke met zogenaamde breast specific gamma
imaging apparatuur die meer opspoort dan de oudere methodes. http://www.komotv.com/news/4481626.html
In 2004 beweerde een Engelse onderzoekster
dat er een verband was tussen deodorants die aluminium bevatte en borstkanker. Door zowel
de fabrikanten als KWF kankerbestrijding werd dit als een hoax afgedaan maar nu is er in
2006 weer een studie gepubliceerd waarin men waarschuwt voor metalen waaronder aluminium
die door zich te binden aan oestrogeen receptoren de werking van deze hormonen kunnen
nabootsen. En juist een verhoogde oestrogeen werking speelt een rol bij borstkanker. Deze
studie noemt oa lood, kwik, nikkel, aluminium, kobalt, koper, nikkel, tin, cadmium (door
het roken!!).
Potential link between aluminium salts
in antiperspirants and breast cancer warrants further research
Chemicals that mimic the body’s
natural hormone oestrogen are known to affect a woman’s risk of breast cancer.
Evidence is mounting that the aluminium-based compound, which often makes up quarter of
the volume of some antiperspirant agents, can break through the skin and that once in the
body it could mimic oestrogen. A review just published in the Journal of Applied
Toxicology calls for further research to evaluate the potential that this could increase
the risk of getting breast cancer.
Over recent years, scientists have found that many compounds in the environment mimic or
interfere with oestrogen. These compounds are normally complex molecules and are found in
many plants, and used in materials like detergents, pesticides and plastics. Now
scientists are realising that a variety of simple metal ions, including aluminium and
cadmium can also bind to the body’s oestrogen-receptors and influence their action.
"Since oestrogen is known to be involved in the development and progression of human
breast cancer, any components of the environment that have oestrogenic activity and which
can enter the human breast could theoretically influence a woman’s risk of breast
cancer," says author of the review Dr Philippa Darbre, who works in the School of
Biological Sciences, at the University of Reading, UK.
Aluminium salts in antiperspirants are a major source of exposure to aluminium in humans.
It is often sprayed into armpits, inadvertently concentrating exposure near to the breast.
In addition, it is often applied immediately after shaving, when the skin is likely to be
damaged and less able to keep the aluminium out. "It is reasonable to question
whether this aluminium could then influence breast cancer," says Darbre.
Her concern is not confined to aluminium. Smoking tobacco introduces cadmium into the
body, and research shows that it too can collect in breast tissue. There are indications
that this accumulation of cadmium may also be linked to an increased risk of breast
cancer, potentially showing one of the reasons why smoking could be linked to this
disease.
"Each of these agents on their own may not have a powerful effect, but we need to see
what happens when a number of them act together – it could be that this would have a
significant effect on diseases like breast cancer," says Darbre.
Studie:
Darbre P D. Metalloestrogens: an emerging class of inorganic xenoestrogens with potential
to add to the oestrogenic burden of the human breast. Journal of Applied Toxicology. 2006;
DOI:10.1002/jat.1135
Al eerder legden onderzoekers een relatie
tussen Noord-Europese landen en borstkanker. Hoe noorderlijker je woont hoe minder
zonlicht en hoe meer borstkanker. Door de zon maakt je huid vitamine D aan. Nu blijkt uit
nieuwe bloedonderzoek bij vrouwen met borstkanker dat vrouwen in de laatste stages de
laagste niveau's van Vitamine D hebben. Blijkbaar heeft deze vitamine een remmende werking
op de vooruitgang vd ziekte. Krijg je te weinig zonlicht dan is het alternatief vette vis
of levertraan eten.
Boerinnen hebben een drie keer zo
hoge kans op borstkanker
Uit een recent Canadees onderzoek blijkt
dat vrouwen die al hun leven lang op een boerderij werken de kans op borstkanker drie keer
zo groot is dan bij andere vrouwen. De vrouwen die later een baan zochten in de
nabijgelegen auto-industrie hadden zelfs een vier keer zo grote kans om borstkanker te
krijgen.
Reden? De blootstelling aan de vele
chemicaliën, met name de gebruikte pesticiden.
Puck de Leeuw (48) is filmmaakster en in de
bloei van haar carrière als ze terminale longkanker krijgt. Prognose: een jaar of minder.
Puck is alleenstaand, maar om haar heen ontstaat een kring van familie, vrienden en buren
die haar bijstaan in deze laatste fase van haar leven. Vanaf het moment dat ze ziek wordt
houdt Puck een videodagboek bij. Deze documentaire laat zien wat er met Puck en haar
omgeving gebeurt als de dood zich aankondigt.
Meer borstkanker bij nachtwerk
Volgens Amerikaanse onderzoekers zou nachtarbeid de kans op borstkanker met 60% verhogen.
Dat is het resultaat van één van de allereerste studies naar een eventueel verband
tussen het kankerrisico en de blootstelling aan licht 's nachts. De studie werd uitgevoerd
bij meer dan 1.600 vrouwen van wie de helft aan borstkanker leed. Bij die vrouwen werd
nagegaan in welke mate ze de laatste 10 jaar voordat de diagnose werd gesteld, waren
blootgesteld aan licht tijdens nachtarbeid. De resultaten tonen aan dat vrouwen die
tijdens die periode van 10 jaar minstens eenmaal in nachtploegen hadden gewerkt, 60% meer
kans lopen op borstkanker dan andere vrouwen.
Het risico stijgt met het aantal uren
nachtarbeid per week. Het is uiteraard nog voorbarig om richtlijnen uit te werken voor
personen die 's nachts aan licht worden blootgesteld. Het zou echter blijken dat alles wat
ons biologische ritme verstoort, een invloed kan hebben op de hormonen en die hebben dan
weer een invloed op het kankerrisico. Een mogelijk mechanisme zou kunnen worden verklaard
door melatonine, een hormoon dat een rol speelt in onze slaap-waakcyclus en waarvan de
synthese wordt gestimuleerd door de duisternis en geremd door licht. Kunstlicht 's nachts
zou dan ook de productie van melatonine kunnen afremmen, hetgeen de synthese van
oestrogenen en dus het risico op borstkanker zou verhogen. Die hypothese strookt met
de resultaten van een andere studie die aantoont dat blinde vrouwen, die een constant
melatoninegehalte hebben, minder kans lopen op borstkanker. [Bron] J. Nat. Cancer
Institute, 20: 1557-1562, 2001
De trieste werkelijkheid - de
arrogantie van de medische "goden"
In en in triest is nog steeds het gebrek
aan samenwerking tussen de gevestigde orde en patiënten die zelf willen beslissen hoe hun
kanker behandeld zal worden. Steeds meer mensen gaan op eigen houtje dingen ondernemen
omdat hun specialist doof lijkt te zijn voor hun persoonlijke wensen. Hoog tijd dat de
patiënt recht op meer inspraak krijgt over zijn eigen behandeling en niet is overgeleverd
aan iemand die niet met je meedenkt. Of blijft het "Chemotherapie geslaagd maar
patiënt helaas overleden" ?
Het verhaal van Julischka, een jonge moeder
met twee zoontjes en een zeer agressieve vorm van borstkanker:
Ik ben Julischka, Z-verpleegkundige, 38
jaar oud, getrouwd en moeder van twee zoontjes van zes en één jaar oud. Bij mij werd op
3 januari 2006 een kwaadaardige borsttumor ontdekt. In deze open brief wil ik mijn
ervaringen die ik nadien heb opgedaan vertellen en dat ik een behandelwens heb die de
artsen tot nu toe niet honoreren. Hierbij roep ik alle artsen op om kennis te nemen
van mijn behandelwens en ik hoop dat er artsen zijn die mij op die wijze willen
behandelen.
De tumor die ik heb is zo agressief dat
de kans groot is dat ik aan deze ziekte zal komen te overlijden, aldus de specialist. In
mijn okselklieren werden ook al tumorcellen gevonden. De tumorcellen kunnen dus ook al in
andere delen van mijn lichaam verspreid zijn. Daarom kan de tumor niet plaatselijk worden
behandeld maar is een overal werkzame chemotherapie nodig. De specialist stelde mij
voor om de behandeling te beginnen met een chemotherapie die als bijwerking heeft dat het
middel de hartspier kan beschadigen. Het is in Nederland gebruikelijk om met dit middel de
behandeling tegen mijn vorm van borstkanker te beginnen. Daarna kan ik behandeld worden
met verscheidene andere geneesmiddelen die de tumorcellen kunnen bestrijden en met
bestraling.
Onderzoekers van het academisch ziekenhuis
Maastricht (azM) hebben een nieuwe behandeling ontwikkeld die zicht biedt op genezing van
uitgezaaide borstkanker zonder dat een operatie nodig is. In een muismodel lukte het de
onderzoekers de kankercellen 'op te ruimen' met donorstamcellen. Via een
stamceltransplantatie werd het immuunsysteem van de muizen als het ware vervangen door het
immuunsysteem van een donor. Het donorafweersysteem herkent de kankercellen als slechte
cellen en ruimt ze op. Uitgezaaide borstkanker kan niet worden geopereerd en bestraling en
chemokuren werken meestal maar tijdelijk. Door de behandeling steeg de overlevingskans van
de muizen met 75 procent.
De "American Cancer Society"
presenteerde onlangs bewijs dat een verband legt tussen overgewicht op latere leeftijd en
borstkanker. De studie op 44,000 vrouwen toonde aan dat hoe meer vrouwen in gewicht
toenamen hoe groter de kans op allerlei types/gradaties van borstkanker. Borstkanker wordt
in verband gebracht met verhoogde niveau's oestrogenen. Vetweefsel produceert extra
oestrogenen waardoor het risico op borstkanker toeneemt.
Onderzoekers van Harvard kwamen al een
onderzoek naar buiten dat vrouwen die hormoontherapie hadden gevolgd ook verhoogde kans op
borstkanker hadden, dit waren dan wel vrouwen die vaak combinaties gebruikten van
oestrogeen en progestine en over een langere periode (15-20 jaar). De vrouwen die het al
20 jaar gebruikten hadden zelfs een 48% hogere kans op borstkanker.
Vrouwen die hormoontherapie gebruiken om
menopause symptomen te onderdrukken hebben bij korte termijn gebruik geen vergrote kans op
borstkanker maar moeten wel beseffen dat oestrogeen wel andere risico's vergroot zoals
hartaanval en bloedklontering.
Gel voor vrouwen die borstkanker
operatie en bestraling
moeten ondergaan
Vrouwen die een operatie moeten ondergaan
vanwege borstkanker gevolgd door bestralingstherapie krijgen vaak te maken met
vervormingen van de borsten waarvoor dan weer een extra hersteloperatie nodig is.
Onderzoekers van het McGowan Institute for Regenerative Medicine, in samenwerking met
bioengineers van de Carnegie Mellon Universiteit hebben nu echter een polymeer gel
ontwikkeld die zowel geleidelijk chemotherapie vrijgeeft en die tevens vulmiddel in de
borst kan worden gebruikt.
In grootschalige onderzoeken in de VS werd
een toename van de kans op borstkanker gevonden bij vrouwen die postmenopauzaal langer dan
vijf jaar oestrogeensubstitutie gebruikten. De kans op het krijgen van borstkanker was bij
deze vrouwen 30-40% groter dan voor vrouwen die geen hormonen hadden gebruikt (Colditz et
al., 1995; Collaborative Group on Hormonal Factors in Breast Cancer, 1997). Tumoren die
onder invloed van hormonale substitutie ontstaan, zijn vaak van het lobulaire type (Chen
et al., 2002a).
Een grote Britse studie bevestigt de eerder gevonden toename van het risico van
borstkanker bij het gebruik van producten met alleen een oestrogeen (toename 20-40%).
Daarenboven toont de studie aan dat de toename van het risico veel groter is (90-210%) bij
het gebruik van een combinatietherapie van oestrogeen en een progestageen (Million Women
Study, 2003).
De toename van de kans op borstkanker is
afhankelijk van de duur van de behandeling. De kans neemt af vanaf het moment dat HST
wordt gestaakt. Vijf jaar na stopzetting van de therapie is het risico van borstkanker
weer hetzelfde als bij vrouwen die nooit HST hebben gebruikt. Er blijkt geen verschil te
zijn in het risico van borstkanker tussen specifieke preparaten of de wijze van
toepassing.
Het College ter Beoordeling van Geneesmiddelen (CBG) adviseert de artsen om bij het
voorschrijven van HST een zo laag mogelijke effectieve dosis te gebruiken, voor een zo
kort mogelijke duur. Met name bij langdurig gebruik moeten de voordelen van HST worden
afgewogen tegen het verhoogde risico van optreden van borstkanker.
Verhoogd risico door
anticonceptiepil
Vrouwen die de pil slikken hebben een
verhoogd risico van 24% op het krijgen van borstkanker in vergelijking tot vrouwen die de
pil niet slikken. Voor vrouwen die 1-4 jaar geleden zijn gestopt met de pil is er een
verhoogd risico van 16%. Vrouwen die 5-9 jaar geleden zijn gestopt met de pil, hebben een
verhoogd risico van 7%. Voor vrouwen die al langer dan tien jaar geen anticonceptiepil
meer slikken is er geen verhoogd risico meer. De duur van het gebruik van de
anticonceptiepil, de dosis en de samenstelling hebben geen effect op het risico. Vrouwen
die vóór de leeftijd van 20 jaar beginnen met het slikken van de pil hebben een wat
hogere kans op het krijgen van borstkanker gedurende het gebruik van de pil. Het absolute
risico van borstkanker is echter laag in deze leeftijdsgroep (Collaborative Group on
Hormonal Factors in Breast Cancer, 1996).
Tweede generatiepil verhoogt kans
op borstkanker met 45%
De pil van de tweede generatie, die ook
door zeer veel vrouwen wordt gebruikt, verhoogt de kans op borstkanker aanzienlijk. Dat
blijkt uit een Noors onderzoek, waarvan de Sunday Times de resultaten publiceert.
Noorse artsen onderzochten 100.000 vrouwen
tussen de 30 en 70 jaar om na te gaan hoeveel van hen te kampen kregen met borstkanker.
Dat leidde tot de conclusie dat wie de 'tweede generatie-pil' meer dan drie jaar lang nam,
45 procent meer gevaar loopt om borstkanker te krijgen.
Volgens de Noorse medici, wier onderzoek in
juli wordt gepubliceerd in de Internationl Journal of Cancer, is de kans op borstkanker
voor gebruiksters van anti-conceptiepillen over de hele lijn 25 procent groter dan bij
vrouwen die deze middelen niet gebruiken. Britse experts relativeerden de resultaten van
het Noorse onderzoek en zeiden dat er 'verschillende factoren een rol spelen bij
borstkanker, waarvan de pil er slechts één is'.
Het Nederlands Tijdschrift voor Geneeskunde
20/05/03
Meer kankerrisico met 1 pil dan met
10 ton verboden hormonenvlees.
Al vele jaren vinden de artsen dat het
vlees van hormoongestimuleerde runderen moet verboden worden omdat de residuhormonen een
hoog kankerrisico teweegbrengen. De auteur vindt dat terecht doch rekent en herrekent dat
men ruim 100 kg rundvlees (0,3 parts per billion) moet eten om evenveel oestrogenen op te
nemen als één dagelijkse hormonenpil. Omdat de pil thans geprepareerd is met het 100
maal sterker werkend ethinylestradiol zou men moeten 10.000 kg rundvlees consumeren - of
circa 50 runderen - om evenveel kankerrisico in ons lichaam te induceren!!! En dan niet
vergeten dat de pil dagelijks wordt genomen. Dus het door de geneeskunde (wegens
kankerrisico) verboden hormonen-beefsteak is 10.000 maal minder gevaarlijk dan de
dagelijks voorgeschreven contraceptieve pil! Aldus de auteur.
Lunatusin, a trypsin-stable antimicrobial
peptide from lima beans (Phaseolus lunatus L.).
Wong JH, Ng TB. Department of Biochemistry,
Faculty of Medicine, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, China.
An anti-fungal peptide designated as
lunatusin, with a molecular mass around 7kDa, was purified from the seeds of Chinese lima
bean (Phaseolus lunatus L.). The peptide was isolated using a simple protocol consisting
of affinity chromatography on Affi-gel blue gel and gel filtration on Superdex 75.
Lunatusin exerted an anti-fungal activity toward fungal species such as Fusarium
oxysporum, Mycosphaerella arachidicola and Botrytis cinerea, and an antibacterial action
on, Bacillus megaterium, Bacillus subtilis, Proteus vulgaris and Mycobacterium phlei. It
also inhibited proliferation in the breast cancer cell line MCF-7. Lunatusin
reduced the activity of HIV-1 reverse transcriptase and it also inhibited translation in a
cell-free rabbit reticulocyte lysate system. Its anti-fungal activity was retained after
incubation with trypsin. Lunatusin elicited a mitogenic response from mouse splenocytes.
Dat er bij mijn vrouw borstkanker werd
vastgesteld is een gegeven dat inslaat als een bom , bij zowel patient als
familie(echtgenoot ).
Dat snelle hulp vereist is mag duidelijk zijn en ik moet zeggen dat dat allemaal snel
geregeld was. Er werd een borstbesparende operatie gedaan en die is goed verlopen. Maar
bij het vervolg trajekt zijn er toch verschillende dingen niet goed gegaan, welke ik uit
de doeken zal doen.
Bij het geregeld bellen en nakijken op
websites van verenigingen welke kanker in hun takenpaket hebben, werd ik uiterst korrekt
behandeld en van
informatie voorzien. Daar zijn wij dankbaar voor . Maar toen mijn vrouw voor controle
moest naar Daniel de Hoedkliniek en het Dijkzichtziekenhuis werden er wel gesprekken
gehouden, maar er werd niet bijverteld dat er ook alternatieve middelen waren.
Op een tip van een dezer verenigingen kwam
ik op de website Kanker-aktueel en na lang zoeken bleek dat er WEL een alternatievemethode
is en dat dat de ASAM-test is. Deze komt uit Amerika, kost 160 dollar en is zo goed en
eenvoudig dat deze test voor 99 0/0 nauwkeurig is . Ook bij bestralingen geven artsen geen
100 0/0 garantie . Zelf ben ik nu ook onder behandeling van een arts, en die zei het
vreemd en niet goed te vinden dat artsen van grote ziekenhuizen geen informatie geven aan
zulke patienten.
Mijn redenatie is dat je alles stap voor
stap moet doen en eerst een eenvoudige test kan doen en dan pas moet bestralen als er nog
kankercellen zitten. De bijwerkingen van bestraling kunnen van patient tot patient
verschillen . Maar ik ben van mening dat Professoren, Radiotherapeuten of wat het nog meer
mag zijn verplicht zijn om duidelijke onhafhankelijke informatie te geven. De mediche
wereld denkt dat iedereen maar achter hun aanholt en dat hun het allemaal wel weten. Maar
ik ben bang dat er een soort tunnelvisie ontstaat en dat zij altijd gelijk hebben.
Daarom wil ik dit aan de kaak stellen , ik
begrijp ook wel dat niet iedereen het met mij eens is. Maar als ik dan hoor uit
betrouwbare bron dat deze test al bij verschillende personen goed heeft gewerkt dan zet ik
mijn vraagtekens bij het verzwijgen hiervan. Ik denk dat geld hiervan de oorzaak is, grote
dure apparatuur moet werken en een eenvoudige test zou dat wel eens kunnen doorkruisen. Ik
hoop dat mensen die dit lezen zelf eens op zoek gaan naar Kanker-aktueel en zelf kunnen
bepalen wat ze willen en niet aan de halsband van dure doktoren moeten lopen .
Ginseng zorgt voor grotere
overlevingskans bij borstkanker
Vrouwen die het kruid Ginseng gebruiken
hebben een grotere kans om borstkanker te overleven en een beter kwaliteit van leven te
hebben na de behandeling blijkt uit een nieuwe Chinese studie.
De studie volgde gedurende 6 jaar 1455
Chinese vrouwen die behandeld waren voor borstkanker. De vrouwen die reeds Ginseng
gebruikten hadden een 30% kleinere kans op te overlijden tijdens de 6 jaar die zij gevolgd
werden.
De vrouwen die Ginseng pas na de diagnose
gingen gebruiken voelden zich emotioneel beter en hadden een aktiever sociaal leven dan de
vrouwen die geen Ginseng gebruikten.
Pregnancy nausea/vomiting may indicate lower risk of breast cancer
It may not seem so at the time, but women who suffer through morning sickness during their
pregnancies actually may be fortunate. Those women may have a 30 percent lower risk of
developing breast cancer later in life than mothers-to-be who experience nine nausea-free
months, a new study by epidemiologists at the University at Buffalo suggests.
Elderly breast cancer care 'poor Breast cancer scan
Older women with breast cancer get poorer care than younger women, a study has found.
Researchers from the University of Manchester found they are less likely to get a range of
diagnostic tests and treatments. Writing in the British Journal of Cancer, they say this
is likely to lead to higher rates of cancer recurring, and higher death rates. [Ben
Licher]
Revolutionary Invention May Aid in the Prevention of Breast Cancer
Medical anthropologist Sidney Ross Singer and his colleagues theorized that conventional
brassieres may contribute to the development of breast cancer because they constrict the
lymph glands, which are the "garbage collectors" of the body. If lymph flow is
restricted, it is difficult for toxins to be removed from the breast area and, over time,
those toxins may accumulate and, in turn, promote disease.
Patients Younger Than 70 With Estrogen-Sensitive Tumors Show Steepest Drop. U.S. women's
breast cancer deaths dropped 24 percent from 1990 to 2003, a new study shows. Women
younger than 70 with estrogen-sensitive breast cancers had the biggest decline in breast
cancer deaths during that period. [Ben Licher]
The Women’s Health Initiative Randomized Controlled Dietary Modification Trial was
designed to study a low-fat diet, a nutritional approach to prevention of chronic diseases
that was considered promising. The negative findings from the trial were both unexpected
and disappointing to nutrition authorities. The authors’ public responses to the
findings articulated an unwillingness to believe the finding that a low-fat diet did not
prevent breast or colon cancer or heart disease. The negative results should stimulate
work on alternate hypotheses, and reconsideration of the long-standing proscription
against dietary fat.
Ms Williamson’s study involved two trials with healthy postmenopausal women. The
answer to reducing your risk of breast cancer could very well come down to flaxseeds,
according to the latest research by an RMIT University postgraduate researcher.
A new study in the Journal of Clinical Oncology shows that women with breast cancer can
greatly reduce their risk of cancer recurrence by exercising and eating a plant-based diet
rich in fruits and vegetables.
216 environmental compounds caused breast cancer in animals.
The free, searchable database reveals that exposure to potential breast cancer-causing
agents is widespread from chemicals used in consumer products, food, women's workplaces,
and in air and water pollution. The database includes references to 900 studies of which
460 are human breast cancer studies. The researchers stressed that 29 of the potential
cancer-causing carcinogens are found in massive amounts in the U.S., but little is known
yet about their effects on human health. The database shows 216 environmental pollutant
compounds that cause breast cancer in animals including73 that are present in consumer
products or as contaminants in food. Ten of these are registered with the FDA for use as
food additives, 35 are air pollutants, 29 are produced in the United States in large
amounts, often exceeding 1 million pounds per year, 25 have been associated with
occupational exposures affecting more than 5,000 women a year.
A groundbreaking research study coordinated by the non-profit Silent Spring Institute and
recently published by the American Cancer Society found that synthetic chemicals have
likely played a large role in the rising incidence of breast cancer throughout the world
over the last half-century. The study identified 216 man-made chemicals — including
those found in everyday products like pesticides, cosmetics, dyes, drugs and gasoline (and
diesel exhaust) — that have been shown to cause breast cancer in animals.
An analysis co-authored by a Roswell Park Cancer Institute researcher found that common
chemicals, such as car exhaust and grilled food, cause breast cancer in animals. The
research team analyzed hundreds of studies that linked environmental exposures and the
disease. The team included Kirsten Moysich from Roswell and researchers from four
institutions in the Boston and Los Angeles areas.
Soy estrogens and breast cancer - Researcher offers overview
Are soy products healthy additions to a person’s diet, safe alternatives to
hormone-replacement therapy or cancer-causing agents? The answer, according to University
of Illinois food science and human nutrition professor William Helferich, is, "It
depends."
Among the more insidious aspects of cancer is its capacity for escaping the anticancer
defenses of the host. New research suggests that some estrogens may further reinforce this
evasion of host immunity, even as those same hormones stimulate the growth and spread of
hormone-responsive cancers. According to David Shapiro, a medical and biochemistry
professor at the University of Illinois at Urbana–Champaign, the new findings
highlight the role that estrogen-related interference with immune cell function may play
in the development and progression of breast cancer.
A genetic 'gang of 4' drives spread of breast cancer
Studies of human tumor cells implanted in mice have shown that the abnormal activation of
four genes drives the spread of breast cancer to the lungs. The new studies by Howard
Hughes Medical Institute researchers reveal that the aberrant genes work together to
promote the growth of primary breast tumors. Cooperation among the four genes also enables
cancerous cells to escape into the bloodstream and penetrate through blood vessels into
lung tissues.
Drug Industry Increasingly Influences Breast Cancer
Breast cancer treatment trials supported by the pharmaceutical industry are more likely to
report positive results than non-sponsored studies, according to a study to be published
in the April 1, 2007 issue of CANCER, a peer-reviewed journal of the American Cancer
Society. In addition, there are significant differences in the design of trials and types
of questions addressed by pharmaceutical industry sponsored trials compared to
non-sponsored trials. The study is the first to examine the impact of the pharmaceutical
industry on breast cancer research.
American College of Physicians warns women in their 40s about dangers of mammograms
The American College of Physicians has recommended women in their 40s consult with their
doctors before undergoing routine annual mammography screening. An expert panel from the
American College of Physicians (ACP), which represents 120,000 internists, made this
recommendation in the April 3rd issue of the journal Annals of Internal Medicine. After
reviewing 117 studies conducted between 1966 and 2005, the panel found the data on
mammography screening for women in their 40s are so unclear that the effectiveness of
reducing breast cancer death could be either 15 percent or "...nearly zero." The
panel pointed out that benefits must be weighed against the harmful effects of mammograms,
including exposure to radiation and unnecessary biopsies, surgery, and chemotherapy.
Singapore scientists find risk gene for breast cancer
Scientists have discovered a risk gene for breast cancer, according to a local media
Channel NewsAsia report on Monday. Scientists from the Genome Institute of Singapore and
the Karolinka Institute, together with over 20 other international collaborating research
groups, made the discovery from a research involving 30,000 women, half of whom have
breast cancer.
Breast cancer rates fell sharply in 2003, and the lower rate remained in 2004, researchers
are reporting today.The most likely reason for the fall in rates, the investigators, led
by Donald A. Berry of M. D. Anderson Cancer Center in Houston, said, was that largenumbers
of women stopped taking hormone therapy for menopause. [Ben Licher]
Traditional Chinese Medicinal Herbs May Help Women With Breast Cancer
Using Chinese herbs either alone or in conjunction with chemotherapy may help protect a
breast cancer patient's bone marrow and immune system,as well as improving the woman's
overall quality of life. [Ben Licher]
Risk of Second Primary Cancer in Men with Breast Cancer
A retrospective registry-based cohort study was conducted to examine the risk of second
primary cancer following the occurrence of breastcancer in males. Conclusion - Male breast
cancer patients should be monitored carefully for the occurrence of second primary
cancers, especially a second primary breastcancer. [Ben Licher]
In a recent study, women getting over breast cancer treatment who participated in an
8-week supervised aerobic and strength training program improved their physical fitness
and quality of life. Now, a follow up study of the women indicates that some of the
physical fitness gains last well beyond the training period. [Ben Licher]
Does a young woman living with a smoker or taking a job working in a smoky bar have a
greater chance of developing breast cancer? Some scientists believe that such situations
can indeed raise a woman's risk of developing breast cancer before the age of 50. Because
epidemiological and toxicological studies show that women's breast tissue may be
especially sensitive to exposure to carcinogens prior to first pregnancy, these
researchers contend that public education should be directed at alerting adolescents and
young women to the potential risk.
Women who had their tonsils removed in childhood may be at increased risk of developing
pre-menopausal breast cancer, according to University at Buffalo researchers.
Breastfeeding can offset the increased risk of breast cancer faced by women who have their
first baby after they turn 25, new research suggests. "Breastfeeding offers
protection against breast cancer for all women, even those who have their first full-term
pregnancy later in life," says Giske Ursin, MD, PhD, associate professor of
preventive medicine at the Keck School of Medicine of the University of Southern
California in Los Angeles.
Study Recommends Emu Oil to Reduce the Appearance of Scars From breast Surgery
A first of its kind study out of Albany, New York reported that patients recovering from
post-operative breast surgeries show a dramatic improvement in scar healing and appearance
after using an emu oil based treatment.
Study May Explain Why Alcohol Consumption Boosts Breast Cancer Risk
This study presents the first animal model to confirm that alcohol consumption stimulates
tumor growth and malignancy of breast cancer, and reveals some of the mechanisms of
alcohol-induced breast cancer.
Device to Locate Magnetic Nanoparticles in Lymph Nod
High-temperature superconductors hold the key to a handheld tool for surgeons that
promises to be more accurate, cost-effective and safer than existing methods for staging
and treating various cancers, including breast cancer.
Audrius Brazdeikis, research assistant professor of physics in the College of Natural
Sciences and Mathematics at the University of Houston, and Quentin Pankhurst, a professor
of physics from the University College of London (UCL), have developed a novel detection
procedure combining nanotechnology and advanced magnetic sensing based on high-temperature
superconductors. Their innovation will enable surgeons to more effectively locate the
sentinel lymph node – the first lymph node to which a tumor’s metastasizing
cancer cells will drain.
The researchers produced an ultrasensitive magnetic probe to detect minuscule magnetic
fields in the body. The probe is a supersensitive magnetometer – an instrument used
to track the presence of clinically introduced magnetic nanoparticles. During breast
cancer surgery, a surgeon will inject a magnetic nanoparticle dye, already approved as an
imaging contrast agent by the Food and Drug Administration, into the tumor or into tissues
surrounding the tumor.
The first study, based on interviews with 15,000 women, shows that women who get more than
six hours of strenuous exercise a week, and have no family history of breast cancercancer,
may be 23% less likely to develop the disease than women who don't exercise at all. The
second study shows a 12-week group exercise program may boost mood and physical function
in women with early-stage breast cancer. The researchers don't promise exercise will
prevent breast cancer, or blame breast cancer on a lack of exercise. Many factors affect
cancer risk.
The risk of a Canadian woman developing breast cancer in her lifetime is one in nine, but
the causes are harder to pinpoint. Jeanne Rizzo, executive director of the San
Francisco-based Breast Cancer Fund, will speak at McGill University on the need to curb
the breast cancer epidemic by expanding the definition of prevention beyond routine
screenings to include public-health policies that recognize the link between toxic
chemicals and the rise in the disease. Ms. Rizzo’s talk, “Cosmetics, Chemicals
and Breast Cancer,” is this year’s Muriel V. Roscoe Annual Lecture and Lanie
Melamed Memorial Lecture. It will be held at New Residence Hall, Ballroom A, 3625 Parc, at
6 p.m. Tuesday, March 13. The Breast Cancer Fund’s goal is to eliminate the
disease’s environmental and other preventable causes.
Addressing Chemical Exposures Through Policy and Market Based Campaigns
Founded in 1992, Breast Cancer Fund is the only national organization focused solely on
preventing breast cancer by identifying and eliminating the environmental causes of the
disease. Part of our work as advocates for prevention is to look at everyday chemical
exposures that may be linked to breast cancer. The public is inundated with the message
that “prevention is early detection.” Yet, more and more scientific evidence is
linking increasing rates of breast cancer and other diseases to increased chemical
exposures. Making these linkages understandable to the general public is best accomplished
in a context that is easily understandable. The Campaign for Safe Cosmetics uses a market
based campaign as well as a legislative strategy to seek reform of the largely unregulated
cosmetics industry. It is also a useful and approachable way to talk about chemicals in
consumer products that may be linked to cancer and cancer prevention. Through the work of
the campaign, the public is being educated about toxic chemicals that are in the products
they use every day. The Campaign also empowers the public to practice prevention in their
daily lives while creating activists who are willing to speak out about unacceptable
chemical exposures and demand greater corporate and government protections and
accountability.
Atrazine and similar reproductive cancers in people
Considering the prevalence of atrazine in the environment, the continued rise of cancer as
the leading cause of death in the US (and with breast cancer and prostate cancer being the
most common cancers in men and women, respectively), the current findings raise concern
for the impact of atrazine on environmental and public health. This is especially
troubling because African American and Hispanic Americans, more likely to be
occupationally exposed to pesticides and less likely to have proper access to healthcare,
are two to four times more likely to die from breast and prostate cancer.
Study aims to find which breast cancer patients need chemotherapy
Most postmenopausal women with small breast tumors don’t need chemotherapy to reduce
their recurrence risk after lumpectomy. To try to determine who does, a test that measures
a tumor’s aggressiveness based on its DNA will be tested nationally in more than
10,000 of these women. “The dilemma physicians have with these patients is, because
they have such small tumors, it’s hard to tell who needs chemotherapy,” said Dr.
Thomas A. Samuel, Medical College of Georgia hematologist/oncologist specializing in
breast cancer and a study principal investigator.
An increasing number of doctors are contesting the claim that annual mammograms decrease
women's risk of dying from breast cancer. Danish researcher Dr. Peter Gotzsche first made
this claim in a study published in "The Lancet" in October 2006. Gotzsche had
re-analyzed the studies originally done on the benefits of mammograms and found them
unconvincing.
Breast cancer screening harms ten women for every one it helps
A new study by researchers from the Nordic Cochrane Centre in Denmark found that
mammograms may harm ten times as many women as they help. The researchers examined the
benefits and negative effects of seven breast cancer screening programs on 500,000 women
in the United States, Canada, Scotland and Sweden. The study's authors found that for
every 2,000 women who received mammograms over a 10-year period, only one would have her
life prolonged, but 10 would endure unnecessary and potentially harmful treatments.
Changes In Breast Density May Impact Breast Cancer Risk
Changes in breast density within a three year period may impact breast cancer risk,
according to a new study. The two measurements of breast density needed to calculate that
change may better predict a woman's risk of breast cancer than a single measurement.
Radiation for breast cancer ups heart disease risk
As a treatment for breast cancer, radiation, even modern regimens, appears to increase the
risk of cardiovascular disease, according to a report in the Journal of the National
Cancer Institute for March 7.Earlier reports have indicated that radiotherapy regimens
used in the 1970s elevate heart disease risk, but it has been less clear if more recent
regimens also increase the risk.
New radiation therapy gives breast cancer patients a more direct treatment option
MammoSite is a partial breast radiation treatment comprised of a balloon catheter that
internally delivers radiation to the tumor. Treatment is completed in five days. And
radiation exposure to the rest of the breast, skin, ribs, lungs and heart is minimized.
Traditional external beam radiation typically is a six- to eight-week treatment that
exposes the entire breast to the radiation.
Could chemopause be the answer to treat breast cancer?
The shutdown of the ovaries is called chemopause, and women who choose to go this route
receive monthly injections -- considered a super-hormone treatment -- of a drug that
blocks the male hormone testosterone and is often used to treat prostate cancer.
Chemopause has big advantages. It doesn't require surgery. And it's not permanent. Women
who want to have children can stop the treatment in order to conceive. And women who have
trouble with side effects can discontinue use of the surgery-sparing drugs.
Link between immune system and mammary gland could shed new light on breast cancer
Scientists at the University of Cambridge have published new research today (July 5) in
the journal Development showing an unexpected link between a fundamental part of the
immune system and the cells that produce milk in the breast during lactation.
Surgeon Develops Procedure To Prevent Arm Swelling In Breast Cancer Patients
A surgeon at the University of Arkansas for Medical Sciences (UAMS) has developed a new
procedure to prevent one of the most common side effects associated with breast cancer
treatment – lymphedema or swelling of the arms due to faulty drainage of the lymph
nodes.
V. Suzanne Klimberg, M.D., director of the UAMS breast cancer program, led a study funded
by the Tenenbaum Breast Cancer Research Foundation of breast cancer patients at risk for
developing lymphedema. Her findings were published in the February issue of the Annals of
Surgical Oncology, and she will present the study March 17 at the Society of Surgical
Oncology 60th Annual Cancer Symposium in Washington, D.C.
“The removal and analysis of the lymph nodes under the arm remains the most important
factor in determining the severity of disease in breast cancer patients,” Klimberg
said. “In the past, surgery to remove the lymph nodes and most of the fat and tissue
in the armpit often resulted in complications, including lymphedema.” Five percent to
50 percent of women undergoing surgical treatment for breast cancer have developed
lymphedema, mainly dependent upon the extent of surgery.
High-fat diet may increase breast cancer risk A large study of middle-age women with a
wide range of fat in their diet shows that eating a high-fat diet raises the risk of
developing invasive breast cancer.
UBC Discovery May Lead to “Smart” Therapies for Breast, Ovarian Cancer
New non-toxic and targeted therapies for metastatic breast and ovarian cancers may now be
possible, thanks to a discovery by a team of researchers at the University of British
Columbia.
In a collaboration between UBC stem cell and cancer scientists, it was found that a
protein called podocalyxin -- which the researchers had previously shown to be a predictor
of metastatic breast cancer -- changes the shape and adhesive quality of tumour cells,
affecting their ability to grow and metastasize. Metastatic cancer is invasive cancer that
spreads from the original site to other sites in the body.
The discovery demonstrated that the protein not only predicted the spread of breast cancer
cells, it likely helped to cause it. The findings were recently published online by the
Public Library of Science.
“We believe we’ve found a new important culprit in metastatic breast cancer,
which opens up an entirely new avenue of cancer research,” says Calvin Roskelley, an
associate professor of cellular and physiological science who specializes in breast cancer
and is co-senior principal investigator. “The culprit is hiding in plain sight on the
surface of tumour cells, so we are now developing “smart” molecules to block its
function. The ultimate goal is to generate new targeted, non-toxic treatments -- very
different from the standard ‘slash and burn’ chemotherapy.”
Src inhibitors may prove beneficial in breast cancer therapy
Estrogen, which binds estrogen receptor alpha (ER-alpha), is a risk factor for breast
cancer development. However, one-third of new breast cancers lack detectable ER-alpha.
These ER-alpha–negative cancers are more aggressive and have a worse prognosis than
do ER-alpha–positive breast cancers, and have been thought to be estrogen
independent. In a new JCI study, University of Miami researchers shed further light on the
mechanisms regulating ER-alpha expression levels during breast cancer.
Like Herceptin, Tykerb zeros in on and blocks the effects of HER2, a protein that is
overproduced in certain breast cancers, stimulating their growth. Both drugs are referred
to as "targeted" because of this specificity. Herceptin blocks HER2's action
from the outside of the cell. Tykerb, on the other hand, works on the inside of the cell.
This difference may explain why Tykerb works for some women for whom Herceptin is no
longer effective. The FDA approved Tykerb on the basis of a study of 400 women, half of
whom received the new drug in combination with Xeloda for a 21-day treatment cycle, while
the other half were given Xeloda alone. In the combination group, tumors took longer to
start growing again. Although considered statistically significant, the average time
difference between the two groups was only a little more than eight weeks.
Dietary Lignan Intake and Postmenopausal Breast Cancer Risk by Estrogen and
Progesterone Receptor Status
High dietary intakes of plant lignans and high exposure to enterolignans were associated
with reduced risks of ER- and PR-positive postmenopausal breast cancer in a Western
population that does not consume a diet rich in soy.
Study finds Western-style 'meat-sweet' diet increases risk of breast cancer in
postmenopausal women
A new study finds that the more "Western" the diet -- marked by red meat,
starches and sweets -- the greater the risk for breast cancer among postmenopausal Chinese
women. According to researchers who conducted the analysis at Fox Chase Cancer Center in
Philadelphia, Harvard University, Shanghai Cancer Institute and Vanderbilt University, the
findings mark the first time a specific association between a western diet and breast
cancer has been identified in Asian women.
Study Fails to Show Benefits of Fruits and Veggies for Breast Cancer Patients Women are
Blamed, but the Investigators Were at Fault
The meat and dairy industry must have been laughing all the way to the bank on Tuesday
July 17, 2007 when headlines worldwide announced the results of a seven-year diet
experiment, known as The Women’s Healthy Eating and Living (WHEL) Randomized Trial,
of more than 3,000 women with breast cancer. This government funded study (kicked off by a
$5 million grant from the late Wal-Mart heir John Walton with an additional $30 million in
support from the National Cancer Institute) found no benefit from recommending that women
with breast cancer eat more fruits and vegetables, and less fat. The chances of fewer
recurrences and better survival were not seen in women previously treated for breast
cancer after changes in diet achieved during this study. As a result of this paper,
originally published in the Journal of the AmericanMedical Association, more people now
believe healthier eating will not help women prevent or treat breast cancer.
The first molecular-based laboratory test for detecting whether breast cancer has spread
(metastasized) to nearby lymph nodes was approved by FDA on July 16, 2007.
Postmenopausal Sex Hormones and Breast Density Are Each Associated with Breast Cancer
Risk
Sex hormone levels and breast density are independent risk factors for breast cancer in
postmenopausal women. Breast density and hormone levels are both well-known predictors of
breast cancer, but it is unclear whether hormone levels regulate breast density. Rulla
Tamimi, Sc.D., of Brigham and Women’s Hospital in Boston and colleagues measured
breast density and estrogen and testosterone levels in postmenopausal women who later
developed breast cancer and those who did not. They found that sex hormone levels and
breast density are strongly and independently associated with breast cancer risk.
More Evidence for Breast Cancer Declines as HRT Use Drops
Researchers here believe they've successfully tied a recent decline in breast cancer
incidence to the rapid drop in use of hormone replacement therapy after 2002.
Survival Disadvantage Seen for Triple-Negative Breast Cancer
A new study clearly reveals the survival disadvantage for the so-called
"triple-negative" subtype of breast cancer compared with other types of breast
cancer. These tumors test negative for estrogen receptor (ER), progesterone receptor (PR),
and the human epidermal growth factor receptor 2 (HER2) and do not respond to any form of
endocrine therapy. [Ben Licher]
Breast cancer studies supported by drug companies are more likely to report positive
results than those without pharmaceutical industry backing, according to a new study.
Medical researchers may have a new way to find diseased cells when screening for breast
cancer. Scientists from Harvard University Medical School have developed a chemical that
highlights cancerous tumor cells.
Scientists develop new drugs to fight colon and breast cancer more effectively
A new technique called "microarrays" was used in this study, which enables the
identification of the specific effects produced by drugs on each human gene. The study,
conducted in the Department of Human Anatomy and Embryology at the University of Granada,
looked at six new compounds which reduce the side effects of cancer treatment. Results
available in Tetrahedron.
Intake of vitamin D and calcium associated with lower risk of breast cancer before
menopause
Women who consume higher amounts of calcium and vitamin D may have a lower risk of
developing premenopausal breast cancer, according to a report in the May 28 issue of
Archives of Internal Medicine, one of the JAMA/Archives journals.
Traditional Chinese medicinal herbs may help women with breast cancer
Using Chinese herbs either alone or in conjunction with chemotherapy may help protect a
breast cancer patient’s bone marrow and immune system, as well as improving the
woman’s overall quality of life.
Sixty per cent of women undergoing chemotherapy for breast cancer experience a range of
significant short term side effects. These include nausea, vomiting and fatigue, as well
as inflammation of the gut lining, decreased numbers of red and white blood cells and
decreased numbers of blood platelets.
Chinese medicinal herbs include mixtures of herbal compounds or extracts from herbs, and
they are prescribed to counteract the side effects of chemotherapy. This Cochrane
Systematic Review set out to see if there is conventional evidence indicating that these
medicines are safe and whether there is evidence that the medicines are effective.
The researchers identified seven randomised studies involving 542 patients with breast
cancer.
Cryoablation is a safe procedure for breast cancer patients, early results indicate
Ultrasound-guided cryoablation of small breast cancer may be a safe procedure associated
with minimal morbidity and high patient satisfaction, according to a recent case report by
radiologists at the University of Wisconsin Hospital & Clinics in Madison, Wis.
Scientists develop new drugs to fight colon and breast cancer more effectively
A new technique called "microarrays" was used in this study, which enables the
identification of the specific effects produced by drugs on each human gene. The study,
conducted in the Department of Human Anatomy and Embryology at the University of Granada,
looked at six new compounds which reduce the side effects of cancer treatment. Results
available in Tetrahedron.
Test Score Reveals Which Breast Cancer Patients Can Avoid Chemo
A new prospective study shows a 21-gene test of a patient’s breast cancer tumor may
change doctor and patient treatment decisions, including the need for chemotherapy.
Researchers at Loyola University Health System, Maywood, Ill., presented the findings at
the American Society of Clinical Oncology annual meeting.
Taking calcium, vitamin D before menopause reduced risk
New research gives women another good reason to get plenty of bone-strengthening calcium
and vitamin D - The nutrients may reduce the risk of developing breast cancer.
Fat tissue-derived hormone leptin increases e-cadherin expression, obesity-breast
cancer link noted
Being obese increases the risk of breast cancer in post-menopausal women, shortens the
time between return of the disease and lowers overall survival rates. Researchers now
report evidence on how leptin, a hormone found in fat cells, significantly influences
breast cancer development and progression in mice.
Dr Susan E Steck of the University of South Carolina in Columbia and her colleagues found
that post-menopausal women who consumed the most grilled, barbecued or smoked red meat
over their lifetime have a 47 percent increased risk of breast cancer.
Early screening for breast cancer may do
more harm than good
A new study reveals that screening women for breast cancer under the age of 50 might
actually do more harm than good, since of every 10,000 women screened, a small percentage
is actually diagnosed and of these, eventually only 4 are completely cured. In the bargain
thousands of women face high levels of radiation which increase cancer risk, as well as
suffer great emotional anxiety and add to government costs. http://www.earthtimes.org/articles/show/12530.html
Pro-vitamin E shown to be active
against breast cancer cells
A precursor of vitamin E has been shown to be effective against breast cancer cell lines
which over-express human epidermal growth factor receptor (HER2). About 30% of
breast cancers exhibit high levels of HER2 – a feature that appears to make the
disease resistant to many common treatments including chemotherapeutic agents. Now
researchers in Griffith University’s School of Medical Science have shown that
pro-vitamin E or alpha-tocopheryl succinate can reduce tumour volume in experimental
animals with high levels of HER2. Chief investigator Associate Professor Jiri Neuzil said
alpha-tocopheryl succinate (alpha-TOS) had the potential to be an inexpensive, safe and
selective therapy for hard-to-treat breast cancers.
Indiana University researchers
discover unique marker to identify breast cancer protein
Researchers at Indiana University School of Medicine have discovered a way to identify a
key protein in breast cancer cells, raising hopes that it will lead to a significantly
better method for early detection of the disease.
The research, led by Linda H. Malkas, Ph.D., Vera Bradley Professor of Oncology and
professor of medicine, and Robert J. Hickey, Ph.D., associate professor of medicine,
involves a protein, PCNA, that plays a vital role in the processes that control cell
replication, repair and death. The research team identified an antibody that can
differentiate between the normal form of PCNA and the altered form found in breast cancer
cells, Dr. Malkas said.
As a treatment for high-risk breast cancer patients, high-dose cyclophosphamide, thiotepa,
and carboplatin (CTC) is associated with a drop in cognitive performance over time, new
research shows. Previous reports have shown a drop in cognitive performance among breast
cancer survivors treated with cytotoxic therapy, the researchers note in the Journal of
the National Cancer Institute.
Benefit of Aerobic Exercise During
Radiation Therap
Moderate-intensity exercise, such as a brisk 20-minute walk three or more times a week,
maintains or even increases erythrocyte levels during radiation therapy for breast cancer,
researchers report in the November 15th issue of Cancer.
New biomarker predicts effectiveness
of breast cancer drugs
University of Cincinnati researchers have identified a new way to predict when
anti-estrogen drug therapies are inappropriate for patients with hormone- dependent breast
cancer. Researchers suggested the findings could help physicians more accurately predict
which tumors will respond to anti-estrogen therapy and improve long-term survival for
breast cancer patients.
A monoclonal antibody developed by researchers at the University at Buffalo has been shown
to extend significantly the survival of mice with human breast-cancer tumors and to
inhibit the cancer's spread to the lungs in the animals by more than 50 percent.
The antibody, named JAA-F11, targets a particular disaccharide, an antigen known as TF-Ag,
which aids the adhesion and spread of certain cancer cells. While the antibody did not
kill the cancer cells, it blocked stages of cancer-cell growth that allow the cells to
adhere to organ tissue, the research showed.
U.S. breast cancer rates plunged an unprecedented 7 percent in 2003, the year after
millions of women stopped taking menopause hormones when a study showed the pills raise
the risk of tumors.
Vitamin D may help curb breast cancer progression, according to a study published in the
Journal of Clinical Pathology.
The authors, from Imperial College, measured the levels of vitamin D in the blood serum of
279 women with invasive breast cancer. The disease was in its early stages in 204 of the
women, and advanced in the remaining 75.
The results showed that women with early stage disease had significantly higher levels of
vitamin D (15 to 184 mmol/litre) than the women in the advanced stages of the disease (16
to 146 mmol/litre).
Wyeth Hormone Sales Rise Even After
Linked to Cancer
Revenue from the pills, used to treat symptoms of menopause, is expected by analysts to
rise about 5 percent annually for the next several years. A study last week said reported
cases of breast cancer in the U.S. dropped by 7 percent after use of Wyeth's hormone drugs
fell by half from 2002 to 2004.
Daily dose of mushrooms could
prevent breast cancer
Eating mushrooms on a daily basis could help prevent the development of breast cancer,
researchers have found. Researchers from the Beckman Research Institute, California, found
that extracts of the fungi interfere with the action of aromatase, an enzyme that helps
the body to make oestrogen, which has long been linked to the growth spread of most breast
cancer tumours.
Low-fat diet can help prevent breast
cancer recurrence
The study of more than 2,400 women, ages 48 to 79, found the rate of cancer recurrence
after five years was 9.8 percent among women who ate a low-fat diet (about 33 grams of fat
per day) and 12.4 percent among those who ate a standard diet (about 52 grams of fat per
day).
When researchers reported recently that a precipitous drop in breast cancer rates might be
explained by a corresponding decrease in the use of hormones for menopause, women reacted
with shock, anger and, in some cases, profound relief that they had never taken the drugs.
New mothers now have even more incentive to shed pounds gained during pregnancy, other
than wanting to fit into those pre-pregnancy jeans. A new study indicates an association
between gaining weight in adulthood and an increased risk of breast cancer after
menopause.
A Stanford study that shows breast cancer rates are linked to the use of hormone
replacement therapy drugs mirrors the findings of a recent national study. These findings
will create a "conundrum" for doctors in the coming year as women suffering from
menopausal symptoms, including fatigue and memory loss, seek safe treatments, according to
the Stanford University School of Medicine.
Exercise may increase breast cancer
survival for young women
Overweight or obese young women who report moderate or vigorous physical activity during
the year prior to their breast cancer diagnosis have increased five-year survival,
researchers from the University of North Carolina at Chapel Hill have found. The results
show a modest improvement in long-term survival for all women ages 20 to 54 years old who
were active just before breast cancer diagnosis. The effects of physical activity were
most significant for women with a body mass index greater than 25. Understanding the link
between breast cancer and lifestyle factors such as exercise can help explain variation in
survival rates among women, said Dr. Page Abrahamson, who conducted the study as a
graduate student in UNC's School of Public Health. "Disease stage and tumor grade are
estimated to only explain about 20 percent of variation in survival. Identifying other
factors that affect prognosis will help us identify women at increased risk of death and
provide more ways for patients to enhance their survival," said Abrahamson, now a
postdoctoral researcher at the Fred Hutchinson Cancer Center in Seattle, Wash.
Different gene-expression predictors
of breast cancer agree, UNC study shows
Breast cancer researchers at the University of North Carolina at Chapel Hill have
identified a number of activity patterns in the genes of individual tumors that make them
biologically different from others. These findings could provide valuable clinical
information such as how likely the tumors are to be invasive, how well they might respond
to different treatments and how likely they are to recur or spread. Currently, doctors
treating patients with breast cancer make treatment decisions and predictions based
largely on the location and size of the tumor and if the cancer has spread, or
metastasized, to lymph nodes and distant sites of the body. But not all patients who are
similar in terms of these clinical indicators get the same benefits from treatment. These
new findings could remedy that situation. Such differences in gene activity may be used as
biomarkers to identify which treatments can be individually matched.
British scientists have identified a naturally occurring compound, indole-3-carbinol,
found in the cruciferous vegetables, belonging to the mustard family, such as cabbage,
Brussels sprout, cauliflower and broccoli which can prove to be very effective in the
fight against cancer.
Gene associated with breast cancer
may play major role in prostate cancer recurrence
A gene associated with breast cancer also may play a major role in the recurrence of
prostate cancer, according to new research from the University of North Carolina at Chapel
Hill School of Medicine and UNC Lineberger Comprehensive Cancer Center. The most common
cancer in men, prostate cancer can be effectively treated with surgery or radiation when
detected early. But advanced prostate cancer is usually treated by drugs or surgery aimed
at reducing the level of testosterone and other male hormones, or androgens, that
stimulate cancer cell growth. While the disease usually regresses after such treatment,
prostate cancer invariably comes back, although it’s not clear why it recurs and
progresses.
Study links high carbohydrate
diet to increased breast cancer risk
Researchers find the risk of developing
breast cancer twice as great in Mexican women, for whom carbs represent more than half the
daily diet
Carb-conscious dieters may be lowering their risk of breast cancer while they're shedding
pounds, based on the findings of research published in this month's edition of the journal
Cancer Epidemiology, Biomarkers & Prevention.
In a case-control study of 1,866 women in Mexico, those who derived 57 or more percent of
their total energy intake from carbohydrates incurred a risk of breast cancer 2.2 times
higher than women with more balanced diets. Dietary patterns in Mexico are characterized
by higher consumption of carbohydrates and lower intake of fat and animal protein than
those in more affluent western countries.
The team of researchers from the Instituto
de Salud Pública in Cuernavaca, Mexico, and the Harvard School of Public Health in
Boston, suggests that the association between carbohydrates and breast cancer may be
related to elevated levels of insulin and insulin-like growth factor binding proteins in
the blood.
"Scientists have long suspected that
diet was among the factors contributing to breast cancer," said study co-author
Walter Willett, M.D., M.P.H., Dr.P.H, the Fredrick John Stare Professor of Epidemiology
and Nutrition at the Harvard School of Public Health. "Now, with studies like ours,
we are beginning gradually to understand what elements of diet specifically are associated
with the disease, and to grasp the chemical and biological processes that contribute to it
at the cellular level."
Of all the carbohydrate compounds, sucrose
and fructose demonstrated the strongest association with breast cancer risk in the study.
Sucrose is derived from sugar cane, sorghum and the sugar beet; it is most commonly found
in table sugar and sweetened prepared foods and beverages. Fructose is a component of
sucrose and is also found in fruit.
Eating sweets and starches causes a rapid
rise in the body's blood sugar levels, which in turn cues the production of insulin and
triggers a biological process that ultimately can influence carcinogenesis by causing
cells to proliferate.
Insulin and an insulin-like growth factor
also may contribute to higher circulating levels of biologically active estrogens, a risk
factor for breast cancer in pre-menopausal women. Ninety percent of breast tumors are
insulin-receptor positive and over-express the insulin-like growth factor.
The prevalence of type 2 diabetes, often
associated with obesity, reflects an underlying insulin resistance in the Mexican
population generally. Among urban Mexicans, nearly one-third of women between the ages of
12 and 49 are overweight. Yet when the research team took into account body mass index and
other such potentially confounding factors as socioeconomic status, age at first birth,
number of children, and family history of breast cancer, the relationship between
carbohydrate intake and breast cancer remained the same.
Dietary fat – certainly a contributor
to obesity – fared well in the research, showing no significant association with
breast cancer risk overall. Willett noted, however, that the intake of polyunsaturated fat
by the women in the study group was only about half that of the United States population.
Insoluble fiber intake was associated with
lower risk of breast cancer, possibly because fiber may modulate the absorption of
carbohydrates and thus affect the glycemic response.
"This study raises important questions
about high carbohydrate diets, particularly among populations or individuals prone to
insulin resistance. However, one study is not enough to make major changes in diet, and
more work on this topic is urgently needed," Willett said.
Study Finds Cardiac Toxicity Rates High
With Herceptin Use; Can be Reversed With Treatment
The first study to look at "real world" use of Herceptin in advanced breast
cancer patients found a higher incidence of cardiac toxicity - 28 percent of patients
treated - than clinical trials of the drug have reported to date, but also concluded that
the majority of this heart damage could be reversed with treatment.
The study, published online August 14 in the Journal of Clinical Oncology, concludes that
use of Herceptin in patients with metastatic breast cancer "is an acceptable
risk," says the study's lead author, Francisco J. Esteva, M.D., Ph.D., an associate
professor in the Department of Breast Medical Oncology at The University of Texas M. D.
Anderson Cancer Center. http://www.mdanderson.org/departments/newsroom/
display.cfm?id=5877430A
Benefit of Chemotherapy in Breast Cancer
Depends on Estrogen-Receptor Status
When it comes to chemotherapy treatment for women whose breast cancer has spread to
their lymph nodes, the estrogen status of their tumors matters, says a team of researchers
in the April 12 issue of the Journal of the American Medical Association.
Analyzing data from three clinical trials with a total of 6,644 patients, they determined
that chemotherapy works much better in breast cancer that is estrogen receptor-negative
(ER-) than many people think, and conversely, doesn't work as well in estrogen
receptor-positive (ER+) cancer as believed, says the study's lead author Donald Berry,
Ph.D., chair of the Department of Biostatistics and Applied Mathematics at The University
of Texas M. D. Anderson Cancer Center.
This conclusion will come as a surprise to many oncologists, Berry says. Women with
"node-positive" breast cancer routinely are given chemotherapy, regardless of
their tumor type. Women who have ER+ tumors are also given tamoxifen, a drug which
inhibits estrogen use by the cancer cells.
Curcumin, the main ingredient of turmeric and the compound that gives curry its
mustard-yellow color, inhibits metastasis to the lungs of mice with breast cancer, report
researchers at The University of Texas M. D. Anderson Cancer Center.
The study, to be published in the Oct. 15 issue of the journal Clinical Cancer Research,
reports that the spice appears to shut down a protein active in the spread of breast
cancer to a major target for metastasis.
Though the study results are early, researchers found that the nontoxic natural substance
not only repelled progression of the disease to the lungs, but also appeared to reverse
the effects of paclitaxel (Taxol™), a commonly prescribed chemotherapy for breast
cancer that may trigger spread of the disease with use over a long period of time.
Because Taxol is so toxic, it activates a protein that produces an inflammatory response
that induces metastasis. Curcumin suppresses this response, making it impossible for the
cancer to spread. In fact, researchers found that adding curcumin to Taxol actually
enhances its effect. Curcumin breaks down the dose, making the therapy less toxic and just
as powerful while delivering the same level of efficacy.
Gene Found In 90 Percent of Breast Cancers
May Be Cancer Vaccine Target
A gene that appears to help regulate normal embryonic development is found at high levels
in virtually all forms of breast cancer, according to a new study led by Laszlo Radvanyi,
Ph.D., associate professor of breast and melanoma medical oncology at The University of
Texas M. D. Anderson Cancer Center.
The finding, published in the Aug. issue of the Proceedings of the National Academy of
Sciences and available on-line July 25, shows that the gene, normally made in small
amounts in normal breast tissue, somehow becomes over-expressed in breast cancer cells.
Researchers hope to use the cancer-specific protein to train the immune system to
specifically attack breast cancer cells.
“There is a tremendous need for new molecular targets to treat breast cancer,”
Radvanyi says. “There are very few bona fide targets that are exquisitely specific
for breast cancer. We believe this is one of them.”
French fries have appeared in the medical research news once again. This time a large
study examined the correlation between breast cancer incidence later in life and a list of
30 foods eaten during the preschool years. Interestingly, the food with the highest
correlation to breast cancer was French fries. For one additional serving of French fries
per week consumed during ages 3-5 years, the risk of breast cancer increased by 27
percent.
Lymphedema Affects Nearly Half of Breast
Cancer Survivors
It's a medical condition without a cure, but lymphedema is barely recognized as a serious
health problem and often can go undiagnosed. This could change thanks to findings from a
long-term study at the University of Missouri-Columbia's Sinclair School of Nursing.
Lymphedema is caused by a compromised lymphatic system. This can occur after breast cancer
surgery because of possible damage to the lymphatic drainage system. The condition causes
serious swelling in the extremities due to lymph fluid accumulation. In addition to
numerous physical effects, lymphedema also can result in psychological distress because
normal, daily activities become difficult.
Initial Results of the five-year Study of Tamoxifen and Raloxifene, or STAR, released this
week revealed the osteoporosis drug raloxifene has been proven to be as effective as
tamoxifen in preventing invasive breast cancer. Vanderbilt-Ingram Cancer Center was the
only regional participant in the study, one of the largest prevention trials ever
conducted. Initial results show that the drug raloxifene, currently used to prevent and
treat osteoporosis in postmenopausal women, works as well — with fewer side effects
— as tamoxifen in reducing breast cancer risk for postmenopausal women at increased
risk of the disease.
Delivering chemotherapy in a gel may
fight breast cancer and help to reduce breast deformity
Women who undergo surgery for breast cancer followed by radiation therapy often experience
breast deformities that can only be corrected through reconstructive surgery. Researchers
at the McGowan Institute for Regenerative Medicine, in collaboration with bioengineers at
Carnegie Mellon University, have developed a polymer-based therapy for breast cancer that
could serve as an artificial tissue filler after surgery and a clinically effective
therapy.
Stem cells and how to boost them is hot on the research agenda. But stopping them could be
critical too, as evidence implicating stem cells in cancer is mounting. In the human
breast, up to 20 per cent of all tumours are now suspected to originate in stem cells. Now
scientists from the Icelandic Cancer Society and the Faculty of Medicine, University of
Iceland have grown three-dimensional breast cell cultures to reveal unexpected subtleties
about these stem cells that could explain why they spawn malignancies. These stem cells,
Valgardur Sigurdsson remarked during the recent EuroSTELLS Conference in Venice, Italy,
could become targets for cancer treatment and lead to new therapies that wipe out cancer
at its source. The hope is that they might also become useful tools to test new drugs.
Gene Profile to Help Decide on Breast
Cancer Treatment
In 25 to 30 percent of breast cancer patients, tumors regress completely under
chemo-therapy. For sufferers and clinicians alike it would be helpful to have indicators
show-ing in advance who will profit from this often stressful treatment. Scientists of the
German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) and the University
Women’s Hospital in Heidelberg have now identified a specific gene activity profile
which characterizes those tumors that respond by complete regression to a special
treatment regimen.
In breast cancer patients, complete tumor regression in the course of chemotherapy is a
fa-vorable prognostic factor. If the treatment is started prior to surgical removal of the
tumor, doctors can also observe whether the tumor responds by regression as hoped for.
However, not all patients benefit equally from chemotherapy: Depending on the treatment
regimen, no more tumor cells are found in tissue examinations of 25 to 30 percent of
patients after com-pletion of the prescribed treatment cycles. The remaining sufferers do
not or only partially respond to the drugs.
An innovative chemotherapy regimen for breast cancer is a combination of gemcitabine,
do-cetaxel and epirubicin. Clinicians and scientists of the German Cancer Research Center
and the Heidelberg University Women’s Hospital have developed a test to predict in
which pa-tients this drug combination will lead to a complete elimination of tumor cells
in the breast. The test is performed using biopsy material obtained from cancerous knots.
One hundred breast cancer patients whose tumors had not yet started metastasizing were
included in the study.
Using a gene chip representing 21.139 human genes, the researchers identified a specific
pattern of gene activities in the cancer cells of a group of patients. This activity
profile is characteristic of those tumors that are completely eliminated by the triple
therapy. In a sec-ond group of affected women, the scientists subsequently showed that the
success of a triple therapy can be predicted using this activity pattern.
Twijfels over preventieve rol soja bij
borstkanker
Johns Hopkins and Georgetown University researchers conducted a meta-analysis of 18
epidemiologic studies revealing that women who eat soy products may have a slightly lower
risk of developing breast cancer. But the researchers quickly add that inconsistencies and
limitations among the studies raise doubt about the potential benefit, and warn women that
high-dose supplements could do more harm than good.
Ik roep al een jaar om uit te kijken voor
deodorants met aluminium zouten op mijn voorpagina maar krijg nu toch wat onverwachte
bijval:
Kan deodorant de kans op borstkanker
vergroten?
Wetenschappers geloven dat aluminium
zouten in deodoranten de kans op borstkanker kunnen verhogen maar vinden het wel wenselijk
dat deze theorie verder wordt onderzocht. Volgens een artikel in de komende april uitgave
van het Journal of Applied Toxicology kunnen chemicaliën die het het hormoon oestrogeen nabootsen de kans op borstkanker vergroten. Verder komt
er steeds meer bewijs dat deze zouten door de huid heendringen en in het lichaam
terechtkomen en daar oestrogeen kunnen nabootsen.
Ik heb nog even verder gespit en ook een
artikel gevonden over planten die voor hetzelfde probleem kunnen zorgen. Met name
patiënten met verhoogd risico op kanker moeten dus voorzichtig zijn met deze planten.
Researchers have found that several
botanicals can mimic the action of the female hormone estrogen -- a potentially dangerous
situation for women with, or at risk for, cancers such as breast cancer or cancer of the
uterus that grow in response to female hormones.
Verder kunnen chemische oestrogenen zorgen
voor een aandoening "Dysmenorrhea" die te behandelen is door het Progesterone
level te verhogen: Deze aandoening zorgt bij vrouwen voor pijnlijke menstruele krampen.
90% van kankerpatiënten zijn niet
op de hoogte van anti-angiogenesis
De makers van het kanker medicijn Avastin
claimen dat het grootste deel van de kankerpatiënten niet op de hoogte is van de
zogenaamde anti-angiongenesis therapie die al meer dan 1 jaar beschikbaar is. Deze
behandeling zorgt ervoor dat de bloedtoevoer van de tumor wordt afgesneden waardoor de
tumor niet verder kan groeien. De grootste winsten zijn te behalen bij darmkanker,
borstkanker en non-small cell longkanker. Het onderzoek stelt dat zeker de mensen die niet
tevreden zijn over de mogelijkheden van chemotherapie op de hoogte moeten worden gehouden
van nieuwe mogelijkheden zoals deze vorm van kankerbehandeling.
Het preventief controlen op borstkanker is
niet geheel zonder risico's doordat men juist door het gebruik van gamma stralen ook
kanker kan gaan ontwikkelen. Dit verhaal is in het Engels maar toch zeer de moeite waard.
Lijkt een beetje op de bijwerkingen van een chemotherapie waarbij het immuunsysteem (met
name de voorraad anti-oxydanten) flink te leiden heeft met als gevolg een zeer verzwakt
immuunsysteem met alle gevolgen van dien.
However, there is growing evidence that
mammograms which, like any x-ray, involve zapping the patient with radiation can be
positively harmful and even cause the disease they are intended to detect. A Canadian
study, which has yet to be published in full, seems set to confirm the findings of earlier
research which clearly suggests that you are more likely to die from cancer if you undergo
screening than if you don't.
The Canadian study, using the National Breast Cancer Screening Trial, is examining the
effect of mammography on women under 50. Data released so far suggests that women whose
cancer was detected through mammograms have a shorter life expectancy than those who used
self examination alone.
Such concerns are far from new. As long ago as the early 1980s, the late Dr Robert
Mendelsohn, in Male Practice, How Doctors Manipulate Women (Contemporary Books, Chicago,
1982), wrote: "I have been warning for years that annual mammographic screening of
women without symptoms may produce more cancer than it detects." Mendelsohn quoted Dr
C Bailar III, editor in chief of the Journal of the National Cancer Institute, as making
the same point in a 1975 report. "His conclusion was supported by numerous studies,
which suggested that accumulated x-ray doses in excess of 100 rads over 10 to 15 years may
induce cancer of the breast," said Mendelsohn.
Omega 6 vetzuren aanjager van borst
en prostaatkanker
Even schrikken? Uit recent onderzoek door
Dr Millie Hughes-Fulford (San Francisco VA Medical Center) blijkt dat een zuur dat
voorkomt in Omega 6 vetzuren er voor zorgt dat prostaatkanker cellen twee keer zo snel
groeien onder laboratorium omstandigheden. Een Spaans team heeft deze link al eerder
gelegd bij borstkanker, ook daar was versnelde groei te zien onder invloed van omega 6.
Omega 6 zit oa in maisolie en de oliën die bakkerijen in hun produkten gebruiken. Het
probleem is ontstaan doordat de verhouding omega 3 en 6 volledigverstoord
zijn in het moderne dieet. Zestig jaar geleden was de verhouding omega 3 tot omega 6, 2:1
terwijl dit nu 2:50 !!!! Dus de inname van omega 6 is vervijftigvoudigd. Omega 3 zit
voornamelijk in lijnzaadolie en vette vis. De testen zullen worden voortgezet op dieren.
Dit zou ook de stijging verklaren van
prostaatkanker in de VS. In Japan waar veel soja en vette vis wordt gegeten komt
prostaatkanker weinig voor terwijl het in België de tweede oorzaak van sterfte is.
De antioxydant
lupeol (aardbeien, mango's en vijgen) zorgt er juist weer voor dat prostaatkankercellen
worden afgebroken, dit was al eerder ontdekt bij alvleesklier kanker door Professor Hasan
Mukhtar (University of Wisconsin )
Volgens studies in Israel en Amerika hebben
nu ook aangetoond dat granaatappel sap tot celdood bij borstkankercellen kon leiden
maar ook een remmende invloed op prostaatkankercellen kan hebben waardoor ziekte vertraagd
kan worden. De vrucht blijkt zelfs een krachtiger antioxidant te zijn dan groene thee of
rode wijn.
Ook blijkt uit Israelisch onderzoek dat een
plant uit Peru, de Rode Maca (Lepidium meyenii) ervoor kan zorgen dat de prostaat kleiner
blijft en dus minder kans op kanker.
Johns Hopkins Kimmel Cancer Center scientists have completed the first draft of the
genetic code for breast and colon cancers. Their report, published online in the September
7 issue of Science Express, identifies close to 200 mutated genes, now linked to these
cancers, most of which were not previously recognized as associated with tumor initiation,
growth, spread or control. “Just as sequencing the human genome laid the groundwork
for subsequent research in genetics, these data lay the foundation for decades of research
on colon and breast cancers,” says Victor Velculescu, M.D., Ph.D., assistant
professor of oncology at the Johns Hopkins Kimmel Cancer Center.
Order of Chemotherapy,
Radiation Has No Effect on Breast Cancer Survival
For women who have had surgery for early breast cancer, it may not matter whether they
receive follow-up chemotherapy before, after or during radiation therapy, according to a
new review of studies. A woman’s chances of survival or seeing the cancer return are
similar in all three cases, if radiation therapy and chemotherapy begin within seven
months after surgery, the review concludes. However, the studies suggest that certain
toxic side effects in the blood and esophagus — common in chemotherapy and radiation
patients — may be up to 44 percent more likely when the two therapies are delivered
at the same time, said Dr. Brigid Hickey and colleagues at the Southern Zone Radiation
Oncology Service in Brisbane, Australia.
Stem cells in regeneration of
breast tissue in Cancer patients
The American scientists have devised a technique that could put an end to reconstructive
surgery for women recovering from breast cancer. It is expected that the stem cells
derived the patient’s own fat would help in regeneration of breast tissue.
Chemo drugs cause cognitive
decline in breast cancer patients
Chemobrain is a condition of cognitive decline experienced by several cancer patients
receiving chemotherapy. This was confirmed by a recent study conducted on the effect of
chemotherapy on cognitive functions in mice.
Multiple copies of a gene called uPAR are associated with the spread of early-stage breast
cancer, U.S. researchers report. The gene offers a promising target for drugs to slow or
halt the progression of the disease, says a team from the University of Texas Southwestern
Medical Center at Dallas.
Dietary Vitamin E derivative
may be effective for treating and preventing breast cancer
Researchers from the Arizona Cancer Center have identified a chemically altered form of
Vitamin E that demonstrates anticancer properties in mice. Emmanuel T. Akporiaye, Ph.D,,
and Tobias Hahn, Ph.D, Department of Immunobiology, and their colleagues from the
Department of Chemistry, College of Pharmacy, and BIO5 Institute for Collaborative
Bioresearch, created a fat-soluble Vitamin E derivative and incorporated it into the diet
of mice with mammary cancer. Mice eating the Vitamin E-enriched “chow” showed
reduction of tumor volume, and an even greater effect was seen when the chow was eaten as
a cancer preventive. This is the first study to demonstrate the ability of this synthetic
compound to prevent and treat tumors when given as a dietary supplement.
More women are beating breast cancer than ever before. That's thanks to better treatments
and early detection. Mammography is a pretty good screening tool that can pick up cancer
early, while it's still curable with surgery. But there is a type of breast cancer that
often doesn't show up on mammograms. It's called inflammatory breast cancer. It strikes
fast and spreads quickly. But IBC can be stopped if you know the signs and symptoms.
Gamma-linolenic acid (GLA), one of the fats
in evening primrose oil and several other plant oils, inhibits action of Her-2/neu, a
cancer gene that is responsible for almost 30 per cent of all breast cancers, reported US
researchers yesterday.
The team from Northwestern University also
found that when they treated breast cancer cells that overexpressed Her-2/neu with GLA
there was a 30- to 40-fold increased response in the cells to the drug Herceptin
(trastuzumab), a commonly used treatment for this cancer.
Onderzoek naar effect MRT straling
op borstkanker cellen
In-Vitro Studies Show MRT Anti-Cancer
(Human Breast Cancer) Properties
Foundation for Jacobson Resonance (FJR) --
Experimental in-vitro studies at the College of Veterinary Medicine, Mississippi State
University, have revealed anti-cancer properties of MRT, with select
field-schedules, in human mammary carcinoma cell populations.
Foundation for Jacobson Resonance (FJR) --
Experimental in-vitro studies at the College of Veterinary Medicine, Mississippi State
University, have revealed anti-cancer properties of MRT, with select field-schedules, in
human mammary carcinoma cell populations.
Ten million times weaker than the
earth’s steady magnetic field, millions of times weaker than those magnetic fields
emitted by power lines, cellular telephones and computers, these fields are apparently
physiologic. Now, we have evidence that they do play a vital role in the structure and
function of the state of well being in humans. Three energy field schedules (MRT signals)
utilizing the Jacobson Resonator,
consistently suppressed the proliferation rate/viability of neoplastic (cancer) cells
in-vitro.
Subsequent studies led by Principal
Investigator Dr. Cody Coyne at Mississippi State University, have detected a range of
biological proteins -- produced by breast cancer cell types -- have had their profiles
altered following exposure to the same schedules used in the gene studies, referenced
above.
Dr. Coyne states: “Investigations have
identified membrane associated complexes that are expressed at elevated or decreased
levels in MCF-7 populations following exposure to specific multi-frequency pico-Tesla
electromagnetic energy field schedules. Investigations have also detected several mRNA
sequences that are expressed in populations of MCF-7 human mammary carcinoma cells
following exposure to the same schedules that consistently suppressed the proliferation
rate/viability of MCF-7 cell populations.” It is our intent to publish these
experimental findings in the near future.
Dr. Jacobson offers: “We look upon
these findings as critically important. Indeed, we have identified genes and proteins that
are probably involved in suppressing growth and viability of human breast cancer cells
that can be regulated non-invasively. Furthermore, the genes and proteins identified may
serve as “targets” that can function as templates for the design of new
chemotherapeutic agents, and MRT may potentially serve as a viable adjunctive modality to
conventional chemotherapeutic agents. And. finally, MRT instrumentation can be applied as
a research tool for further scientific discovery as we seek to palliate human
suffering.”
For further information please contact
Harvey Grossman, Founder & President of the Foundation for Jacobson Resonance at
1.877.439.0514 in North America, and at 561.208.1775 from outside North
America. For charitable contributions only, call 561.208.1775
Ginseng and breastcancer
We evaluated the anticancer effect of a
range of ginseng compounds in varying doses by adding these compounds to the media in
which the breast cancer cells were grown. When the cancer cells were exposed to the
ginsenosides in a six-day assay, none of the ginsenosides enhanced the growth of the
cells, but the crude fraction we have designated as PQe not only inhibited proliferation
of the cancer cells at all doses but actually caused significant tumor cell death when
administered at high doses. In a ten-day assay, one ginsenoside (Rc) enhanced the
proliferation of the cancer cells, but all other ginsenosides were either neutral or
inhibitory. Again, PQe had the greatest inhibitory effect: after 10 days, the number of
cancer cells had been reduced by 98% compared to control cell cultures.
Primate study shows soy does not
increase breast
cancer risk
A study published in the January 15 2006
issue of the journal Cancer
Research concluded that the estrogenic compounds that occur in soy do not
increase breast cancer risk and
may even help protect some women from the disease. While population studies have found
that women whose diets provide high amounts of soy have a lower incidence of breast
cancer, soy isoflavones have been found to stimulate the growth of breast cancer cells in
culture and in mice. Lead researcher Charles E. Wood, DVM, PhD, of Wake Forest University
Baptist Medical Center remarked, "Our study sought to make sense of these seemingly
contradictory data. Our hypothesis was that estrogen levels in the body may influence the
effects of soy isoflavones."
Breast tumors are often treated with a
combination of tumor removal followed by external beam radiotherapy to the whole breast.
This has been found in several studies to result in the same cure rate as total breast
removal. Sadly, only one third or so of women choose to keep their breast. One of the
reasons for this low number may be that the external radiotherapy can take as long as 7
weeks to give, and this can be too much time away from home or work for some women.
Since 1998, Cancer Treatment Centers of America has had a treatment program which uses 5
days of partial breast brachytherapy (temporary radiation implant) instead of 5 - 7 weeks
of external beam radiotherapy. This shorter time period is a great benefit to all
patients, but especially working women, those who live far away from a radiation treatment
center, and those who just want to get the treatment over with as quickly as possible.
The brachytherapy procedure involves
placing some flexible plastic catheters (tiny tubes) into the breast. The procedure is
performed by a board-certified radiation oncologist (Dr. Kelly or Dr. Flynn), and is done
under ultrasound guidance. Nine times over the following 5 days, the catheters are briefly
connected to our high-dose-rate brachytherapy machine for an internal radiation treatment
through the catheters. These treatments take about 15 minutes each and are painless. On
Friday, the catheters are easily removed, and you will be able to go home on the same day.
During the 5 days of treatment you will be an out-patient and may stay in a guest room in
the building. You will not be radioactive, and can do most of your usual activities during
that period. We have nutrition classes and other activities available during the week.
Artificial Light at Night
Stimulates Breast Cancer Growth in Laboratory Mice
Results from a new study in laboratory mice
show that nighttime exposure to artificial light stimulated the growth of human breast
tumors by suppressing the levels of a key hormone called melatonin. The study also showed
that extended periods of nighttime darkness greatly slowed the growth of these tumors.
The study results might explain why female
night shift workers have a higher rate of breast cancer. It also offers a promising new
explanation for the epidemic rise in breast cancer incidence in industrialized countries
like the United States.
The National Cancer Institute and the
National Institute of Environmental Health Sciences, agencies of the federal National
Institutes of Health, provided funding to researchers at the Bassett Research Institute of
the Mary Imogene Bassett Hospital in Cooperstown, New York and The Thomas Jefferson
University in Philadelphia, Pa. The results are published in the December 1, 2005 issue of
the scientific journal Cancer Research.
"This is the first experimental
evidence that artificial light plays an integral role in the growth of human breast
cancer," said NIEHS Director David A. Schwartz, M.D. "This finding will enable
scientists to develop new strategies for evaluating the effects of light and other
environmental factors on cancer growth."
"The risk of developing breast cancer
is about five times higher in industrialized nations than it is in underdeveloped
countries," said Les Reinlib, Ph.D., a program administrator with the NIEHS' grants
division. "These results suggest that the increasing nighttime use of electric
lighting, both at home and in the workplace, may be a significant factor."
Previous research showed that artificial
light suppresses the brain's production of melatonin, a hormone that helps to regulate a
person's sleeping and waking cycles. The new study shows that melatonin also plays a key
role in the development of cancerous tumors.
"We know that many tumors are largely
dependent on a nutrient called linoleic acid, an essential fatty acid, in order to
grow," said David Blask, M.D., Ph.D., a neuroendocrinologist with the Bassett
Research Institute and lead author on the study. "Melatonin interferes with the
tumor's ability to use linoleic acid as a growth signal, which causes tumor metabolism and
growth activity to shut down."
To test this hypothesis, the researchers
injected human breast cancer cells into laboratory mice. Once these cells developed into
cancerous tumors, the tumors were implanted into female rats where they could continue to
grow and develop.
The researchers then took blood samples
from 12 healthy, premenopausal volunteers. The samples were collected under three
different conditions - during the daytime, during the nighttime following 2 hours of
complete darkness, and during the nighttime following 90 minutes of exposure to bright
fluorescent light. These blood samples were then pumped directly through the developing
tumors.
"The melatonin-rich blood collected
from subjects while in total darkness severely slowed the growth of the tumors.
"These results are due to a direct effect of the melatonin on the cancer cells,"
said Blask. "The melatonin is clearly suppressing tumor development and growth."
In contrast, tests with the
melatonin-depleted blood from light-exposed subjects stimulated tumor growth. "We
observed rapid growth comparable to that seen with administration of daytime blood
samples, when tumor activity is particularly high," Blask said.
According to the researchers, melatonin
exerts a strong influence on the body's circadian rhythm, an internal biological clock
that regulates sleep-wake cycle, body temperature, endocrine functions, and a number of
disease processes including heart attack, stroke and asthma. "Evidence is emerging
that disruption of one's circadian clock is associated with cancer in humans, and that
interference with internal timekeeping can tip the balance in favor of tumor
development," said Blask.
"The effects we are seeing are of
greatest concern to people who routinely stay in a lighted environment during times when
they would prefer to be sleeping," said Mark Rollag, Ph.D., a visiting research
scientist at the University of Virginia and one of the study co-authors. "This is
because melatonin concentrations are not elevated during a person's normal waking
hours."
"If the link between light exposure
and cancer risk can be confirmed, it could have an immediate impact on the production and
use of artificial lighting in this country," said Blask. "This might include
lighting with a wavelength and intensity that does not disrupt melatonin levels and
internal timekeeping."
"Day workers who spend their time
indoors would benefit from lighting that better mimics sunlight," added Blask.
"Companies that employ shift workers could introduce lighting that allows the workers
to see without disrupting their circadian and melatonin rhythms."
Chinese plant doodt borstkanker
cellen die tegen chemotherapie bestand was
Selective toxicity of dihydroartemisinin
and holotransferrin toward human breast cancer cells.
Artemisinin becomes cytotoxic in the
presence of ferrous iron. Since iron influx is high in cancer cells, artemisinin and its
analogs selectively kill cancer cells under conditions that increase intracellular iron
concentrations. We report here that after incubation with holotransferrin, which increases
the concentration of ferrous iron in cancer cells, dihydroartemisinin, an analog of
artemisinin, effectively killed a type of radiation-resistant human breast cancer cell in
vitro. The same treatment had considerably less effect on normal human breast cells. Since
it is relatively easy to increase the iron content inside cancer cells in vivo,
administration of artemisinin-like drugs and intracellular iron-enhancing compounds may be
a simple, effective, and economical treatment for cancer.
Singh NP, Lai H. Department of
Bioengineering, University of Washington, Seattle 98195-7962, USA. narendra@u.washington.edu.
Life Sci. 2001 Nov 21;70(1):49-56
PMID: 11764006
Borstkanker en verzadigd vet en
vlees
Our data suggest that,
among women living in Saudi Arabia, a diet that is high in fat predisposes to breast
cancer development. In terms of nutrients, this high-risk dietary profile translates to a
modest, positive association with total fat intake, saturated fat, and cholesterol. This
is in contrast to an earlier study, which has cast doubt on a positive association between
dietary fat and breast cancer [4]. However, our findings agree with those of
Toniolo et al. [18] and Zaridze et al. [19] who showed a positive
association between high dietary fat intake and breast cancer. Also high animal protein
intake was significantly associated with breast cancer in our study, which supports the
findings of De Stefeni et al. [20] and Levi et al. [21] who showed a
positive relationship between high dietary meat consumption and breast cancer. Boyd et al.
in their quantitative summary of all papers published up to July 2003 on dietary fat and
the risk of breast cancer found intake of saturated fat and meat consumption is associated
with an increased risk of breast cancer [22].
High consumption of
sugar-rich foods, meat and other animal products rich in saturated fats has been recorded
in Saudi Arabia [Khan MA, unpublished report, 1996]. Despite the inconclusive evidence
about diet and disease, it is important to educate the population about the possibility of
a link between dietary habits and cancer and to encourage them to adopt a diet that is low
in calories, saturated fat and meat intake.
