bessen en kanker


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Bessen, aardbeien en kanker


Volgens Amerikaanse collega's vallen ook bessen onder de superfoods net zoals algen (chlorella, spirulina), bonen, tomaten, walnoten, spinazie, broccoli, pompoenen, sinasappels, groene thee, kiemen, acai fruit, ui achtigen zoals knoflook en ui, linzen, rode pepers, noten en zaden, gerstegras en tarwegras, boekweit en quinoa.

In de Zweedse studies hieronder bleek bijvoorbeeld (eerste studie) de remmende werking op darmkankercellen (24-68%) en borstkankercellen (46-74%). Bij gebruik van pure vitamine C (ascorbaatzuur) kon men geen noemenswaardige verminderingen vinden dus het gaat echt om de samenwerking van vitamine C in de bessen met andere stoffen (de zogenaamde synergie).

Ron


Inhibition of cancer cell proliferation in vitro by fruit and berry extracts and correlations with antioxidant levels.

Olsson ME, Gustavsson KE, Andersson S, Nilsson A, Duan RD. Department of Crop Science, Swedish University of Agricultural Sciences, P.O. Box 44, SE-230 53 Alnarp, Sweden. Marie.Olsson@vv.slu.se

The effects of 10 different extracts of fruits and berries on cell proliferation of colon cancer cells HT29 and breast cancer cells MCF-7 were investigated. The fruits and berries used were rosehips, blueberries, black currant, black chokeberries, apple, sea buckthorn, plum, lingonberries, cherries, and raspberries. The extracts decreased the proliferation of both colon cancer cells HT29 and breast cancer cells MCF-7, and the effect was concentration dependent. The inhibition effect for the highest concentration of the extracts varied 2-3-fold among the species, and it was in the ranges of 46-74% (average = 62%) for the HT29 cells and 24-68% (average = 52%) for the MCF-7 cells.

There were great differences in the content of the analyzed antioxidants in the extracts. The level of the vitamin C content varied almost 100-fold, and the content of total carotenoids varied almost 150-fold among the species. Also in the composition and content of flavonols, hydroxycinnamic acids, anthocyanins, and phenolics were found great differences among the 10 species. The inhibition of cancer cell proliferation seen in these experiments correlated with levels of some carotenoids and with vitamin C levels, present at levels that can be found in human tissues.

The same inhibition of cell proliferation could not be found by ascorbate standard alone. This correlation might indicate a synergistic effect of vitamin C and other substances. In MCF-7 cells, the anthocyanins may contribute to the inhibition of proliferation.

J Agric Food Chem. 2004 Dec 1;52(24):7264-71.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?
cmd=Retrieve&db=PubMed&list_uids=15563205&dopt=Abstract


Antioxidant levels and inhibition of cancer cell proliferation in vitro by extracts from organically and conventionally cultivated strawberries.

Olsson ME, Andersson CS, Oredsson S, Berglund RH, Gustavsson KE.
Department of Crop Science, Swedish University of Agricultural Sciences, P.O. Box 44, SE-230 53 Alnarp, Sweden. Marie.Olsson@vv.slu.se

The effects of extracts from five cultivars of strawberries on the proliferation of colon cancer cells HT29 and breast cancer cells MCF-7 were investigated, and possible correlations with the levels of several antioxidants were analyzed. In addition, the effects of organic cultivation compared to conventional cultivation on the content of antioxidants in the strawberries and strawberry extracts on the cancer cell proliferation were investigated.

The ratio of ascorbate to dehydroascorbate was significantly higher in the organically cultivated strawberries. The strawberry extracts decreased the proliferation of both HT29 cells and MCF-7 cells in a dose-dependent way. The inhibitory effect for the highest concentration of the extracts was in the range of 41-63% (average 53%) inhibition compared to controls for the HT29 cells and 26-56% (average 43%) for MCF-7 cells.

The extracts from organically grown strawberries had a higher antiproliferative activity for both cell types at the highest concentration than the conventionally grown, and this might indicate a higher content of secondary metabolites with anticarcinogenic properties in the organically grown strawberries.

For HT29 cells, there was a negative correlation at the highest extract concentration between the content of ascorbate or vitamin C and cancer cell proliferation, whereas for MCF-7 cells, a high ratio of ascorbate to dehydroascorbate correlated with a higher inhibition of cell proliferation at the second highest concentration.

The significance of the effect of ascorbate on cancer cell proliferation might lie in a synergistic action with other compounds.

J Agric Food Chem. 2006 Feb 22;54(4):1248-55

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&
db=pubmed&dopt=Abstract&list_uids=16478244&query_hl=
6&itool=pubmed_docsum

 

 


 


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