Bessen, aardbeien en kanker
Volgens Amerikaanse collega's vallen ook
bessen onder de superfoods net zoals algen (chlorella, spirulina), bonen, tomaten,
walnoten, spinazie, broccoli, pompoenen, sinasappels, groene thee, kiemen, acai fruit, ui
achtigen zoals knoflook en ui, linzen, rode pepers, noten en zaden, gerstegras en
tarwegras, boekweit en quinoa.
In de Zweedse studies hieronder bleek
bijvoorbeeld (eerste studie) de remmende werking op darmkankercellen (24-68%) en
borstkankercellen (46-74%). Bij gebruik van pure vitamine C (ascorbaatzuur) kon men geen
noemenswaardige verminderingen vinden dus het gaat echt om de samenwerking van vitamine C
in de bessen met andere stoffen (de zogenaamde synergie).
Ron
Inhibition of cancer cell
proliferation in vitro by fruit and berry extracts and correlations with antioxidant
levels.
Olsson ME, Gustavsson KE, Andersson S,
Nilsson A, Duan RD. Department of Crop Science, Swedish University of Agricultural
Sciences, P.O. Box 44, SE-230 53 Alnarp, Sweden. Marie.Olsson@vv.slu.se
The effects of 10 different extracts of
fruits and berries on cell proliferation of colon cancer cells HT29 and breast cancer
cells MCF-7 were investigated. The fruits and berries used were rosehips, blueberries,
black currant, black chokeberries, apple, sea buckthorn, plum, lingonberries, cherries,
and raspberries. The extracts decreased the proliferation of both colon cancer cells HT29
and breast cancer cells MCF-7, and the effect was concentration dependent. The inhibition
effect for the highest concentration of the extracts varied 2-3-fold among the species,
and it was in the ranges of 46-74% (average = 62%) for the HT29 cells and 24-68% (average
= 52%) for the MCF-7 cells.
There were great differences in the
content of the analyzed antioxidants in the extracts. The level of the vitamin C content
varied almost 100-fold, and the content of total carotenoids varied almost 150-fold among
the species. Also in the composition and content of flavonols, hydroxycinnamic acids,
anthocyanins, and phenolics were found great differences among the 10 species. The
inhibition of cancer cell proliferation seen in these experiments correlated with levels
of some carotenoids and with vitamin C levels, present at levels that can be found in
human tissues.
The same inhibition of cell
proliferation could not be found by ascorbate standard alone. This correlation
might indicate a synergistic effect of vitamin C and other substances. In MCF-7 cells, the
anthocyanins may contribute to the inhibition of proliferation.
J Agric Food Chem. 2004 Dec
1;52(24):7264-71.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?
cmd=Retrieve&db=PubMed&list_uids=15563205&dopt=Abstract
Antioxidant levels and inhibition
of cancer cell proliferation in vitro by extracts from organically and conventionally
cultivated strawberries.
Olsson ME, Andersson CS, Oredsson S,
Berglund RH, Gustavsson KE.
Department of Crop Science, Swedish University of Agricultural Sciences, P.O. Box 44,
SE-230 53 Alnarp, Sweden. Marie.Olsson@vv.slu.se
The effects of extracts from five
cultivars of strawberries on the proliferation of colon cancer cells HT29 and breast
cancer cells MCF-7 were investigated, and possible correlations with the levels of several
antioxidants were analyzed. In addition, the effects of organic cultivation compared to
conventional cultivation on the content of antioxidants in the strawberries and strawberry
extracts on the cancer cell proliferation were investigated.
The ratio of ascorbate to
dehydroascorbate was significantly higher in the organically cultivated strawberries. The
strawberry extracts decreased the proliferation of both HT29 cells and MCF-7 cells in a
dose-dependent way. The inhibitory effect for the highest concentration of the extracts
was in the range of 41-63% (average 53%) inhibition compared to controls for the HT29
cells and 26-56% (average 43%) for MCF-7 cells.
The extracts from organically grown
strawberries had a higher antiproliferative activity for both cell types at the highest
concentration than the conventionally grown, and this might indicate a higher content of
secondary metabolites with anticarcinogenic properties in the organically grown
strawberries.
For HT29 cells, there was a negative
correlation at the highest extract concentration between the content of ascorbate or
vitamin C and cancer cell proliferation, whereas for MCF-7 cells, a high ratio of
ascorbate to dehydroascorbate correlated with a higher inhibition of cell proliferation at
the second highest concentration.
The significance of the effect of
ascorbate on cancer cell proliferation might lie in a synergistic action with other
compounds.
J Agric Food Chem. 2006 Feb
22;54(4):1248-55
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&
db=pubmed&dopt=Abstract&list_uids=16478244&query_hl=
6&itool=pubmed_docsum
