CryShame is a campaigning group co-founded
by a number of UK parents and professionals who are concerned about the catastrophic rise
in autism spectrum disorders and in the potential link with environmental toxins–
particularly MMR and thimerosol (mercury) containing vaccines. CryShame is not an
anti-vaccine group. Indeed one of the major factors that brings all co-founding parents of
CryShame together is that they all complied with vaccination advice from the department of
health in ensuring their children were vaccinated against the recommended range of
infectious disease from age 2 months onwards. The immediate mission for CryShame is to
support Professor Simon Murch, Dr Andrew Wakefield and Professor Walker-Smith as they
stand accused before the General Medical Council of the UK. CryShame additionally supports
the democratic rights of scientists and medical practitioners to engage in valid research
and to publish relevant findings without fear of prejudice or attack. CryShame exists to
tell the story of what brought these doctors to where they are and to bring public
attention to the plight of thousands of children worldwide who regressed into
autistic-like regression and/or bowel disease following exposure to childhood vaccines.
Onderzoekers van de New York University
School of Medicine hebben opnieuw aangetoond dat bij 85% van de kinderen met autisme in de
darmen vaccin ketens van het mazelvirus zijn aangetroffen. Dit toont opnieuw aan dat de
beruchte BMR vaccinatie niet zonder riciso's is. De kinderen in de studie hadden alle
serieuze ontstekingen in de darmen.
Deze resultaten zijn een herhaling van
studies door Dr Andrew Wakefield in 1998 en patholoog John O'Leary in 2002. Alleen al in
de UK zijn er meer dan 2000 ouders die zeggen dat hun kind normaal ontwikkelden tot het
moment van de BMR vaccinatie.
Zal er iets veranderen? Ik ben bang van
niet. Zoals met andere zaken zoals aspartaam, gsm, dect, chemische toevoegingen aan eten,
aluminium in deo, gentech voedsel zijn er altijd weer wetenschappers die dit stelselmatig
gaan ontkennen om het volk te sussen en hopen dat het weer overwaait. Adviseurs van onze
overheid hebben meestal dubbele agenda's en belangen in de pharma business. Ook gaat het
groter belang (vaccinatiebeleid) voor een kleine groep kwetsbare kinderen die een slecht
ontwikkeld immuunsysteem hebben en de rekening daarvoor betalen.
Mijn zoon Vincent ontwikkelde ook prima tot
het moment dat hij die vervloekte BMR vaccinatie krijg. Twee dagen erna werd hij doodziek
en moest in Zeist naar de kinderarts. Er werd een kweek gemaakt maar die raakte
"kwijt" dus hebben we nooit een uitslag gehad. Hierna veranderde zijn gedrag
sterk en zat ik een jaar later op de afdeling kinderpsychiatrie van het UMC en kreeg de
diagnose "stoornis in het autistisch spectrum" en
"ontwikkelachterstand". Geen van beide zaken komen in de familie van de ouders
voor.
Toen ik het moment van de BMR vaccinatie
noemde werd dit minachtend van tafel geveegd. Die arrogantie zie je keer op keer
terugkomen. Ook mensen met de ziekte ME zijn jarenlang behandeld als was het een
psychische aandoening. Ondanks voldoende bewijs dat er fysieke oorzaken waren bleef men te
arrogant om hun ongelijk toe te geven.
Ron
Dr Richard Halverson How dangerous
is measles
Dr Richard Halvorsen answers the big
questions about MMR, Vaccines and Diseases
New study confirms measles virus in
bowels of autistic children
A study due to be presented June 1st-3rd at
the International Meeting for Autism Research (IMFAR), in Montreal, Canada, has confirmed
the finding of a link between the measles virus in MMR vaccine with childhood autism.
What has this study found?
This study has confirmed the original
UK/Irish findings of measles virus in the inflamed intestinal tissues of children with
autism.
This study confirms that in the examined cases, MMR vaccine is the source of the measles
virus.
Study identifies association
between pattern of MMR exposure and regressive autism
"Is There a 'Regressive Phenotype' of
Autism Spectrum Disorder Associated with the Measles-Mumps-Rubella Vaccine? A CPEA
Study"; Richler J et al. Journal of Autism and Developmental Disorders. 2006; April
28.
A recent multi-center Collaborative
Programs of Excellence in Autism (CPEA) study examined:
(i) whether there is a regressive phenotype of autism;
(ii) whether this phenotype is associated with gastrointestinal symptoms; and,
(iii) whether this phenotype is associated with exposure to the MMR vaccine.
One of the more compelling observations to
emerge from this study was a clear association between significant gastrointestinal
symptoms and regressive autism, compared with children who exhibited features of autism
from an early age. Of particular interest is the observation of an association between
children with the 'regressive phenotype', age of onset of regression, and age of MMR
vaccination.
The authors defined the children of
interest - the 'regressive' phenotype - as those with normal or near normal skills before
MMR vaccination who regressed after MMR vaccination and who had had at least one
gastrointestinal symptom for three consecutive months at some point in his or her life.
When these children were compared with the
remaining autistic group, there was a statistically significant difference in the sex
ratio (more females in the phenotype group); significantly later age of onset in the
phenotype group (a mean of 19 months compared with 14.55 months) and lower age at MMR
vaccination (14.38 months versus 17.71 months).
The later observation is particularly
interesting in view of the fact that age of exposure to measles virus is a major
determinant of the risk of an adverse outcome. Children exposed to measles early in life
are at greater risk of persistent (long-term) infection and delayed neurologic disease.
This risk diminishes as children get older. Persistent infection with measles virus in
children with regressive autism has been reported by Thoughtful House scientists and
replicated in a study that is due to be presented at the International Meeting for Autism
Research (IMFAR) in Montreal June 1-3.
The observation in the current paper that
younger age at MMR vaccination is associated with regressive autism in children with
intestinal symptoms is therefore entirely consistent with an adverse outcome from MMR
vaccine.
It is most surprising that, in view of their findings, the authors conclude in the
paper’s abstract that "there was no evidence that onset of autistic symptoms or
of regression was related to measles-mumps-rubella vaccination." Further
clarification of this apparently irreconcilable contradiction is being sought from the
authors of the study.
Detection of Measles Virus Genomic
RNA in Cerebrospinal Fluid of Children with Regressive Autism: a Report of Three Cases
Findings are consistent with both an MV
etiology for the AE and
active viral replication in these children. They further indicate the
possibility of a virally driven cerebral immunopathology in some
cases of regressive autism. A possible association betweenMMRvaccination and autistic
encephalopathic regression (AE) in previously developmentally
normal children has been reported.
Abnormal Measles-Mumps-Rubella
Antibodies and CNS Autoimmunity in Children with Autism
It is quite possible that vaccines in a
small population of genetically predisposed children may react inappropriately, simply
because of their immature immune system or some other unknown risk factors such as
immunodeficiencies, allergies, chemical toxins or chronic psychological stress. However,
none of these factors has so far been investigated in autism. In recent years, the
immunization-autoimmunity topic has gained quite a bit of public attention. This is quite
possibly because autoimmune diseases are the commonest manifestations of immunizations.
The MMR has been insinuated as a culprit of gastrointestinal problems in some children
with autistic characteristics. Approximately one half of the parents with autistic
children reported autistic regression after the MMR immunization
Abnormal Measles-Mumps-Rubella
Antibodies and CNS Autoimmunity in Children with Autism
Autoimmunity to the central nervous system
(CNS), especially to myelin basic protein (MBP), may play a causal role in autism, a
neurodevelopmental disorder. Because many autistic children harbor elevated levels of
measles antibodies, we conducted a serological study of measles-mumps-rubella (MMR) and
MBP autoantibodies. Using serum samples of 125 autistic children and 92 control children,
antibodies were assayed by ELISA or immunoblotting methods. ELISA analysis showed a
significant increase in the level of MMR antibodies in autistic children. Immunoblotting
analysis revealed the presence of an unusual MMR antibody in 75 of 125 (60%) autistic sera
but not in control sera. This antibody specifically detected a protein of 73-75 kD of MMR.
This protein band, as analyzed with monoclonal antibodies, was immunopositive for measles
hemagglutinin (HA) protein but not for measles nucleoprotein and rubella or mumps viral
proteins. Thus the MMR antibody in autistic sera detected measles HA protein, which is
unique to the measles subunit of the vaccine. Furthermore, over 90% of MMR
antibody-positive autistic sera were also positive for MBP autoantibodies, suggesting a
strong association between MMR and CNS autoimmunity in autism. Stemming from this
evidence, we suggest that an inappropriate antibody response to MMR, specifically the
measles component thereof, might be related to pathogenesis of autism.
Author:
Vijendra Singh, PhD
Biotechnology Center
Utah State University
4700 Old Main Hill, Logan, UT 84322 (USA)
Tel. +1 435 797 7193
Fax +1 435 797 2766
EMail singhvk@cc.usu.edu
The Journal of pediatrics, (1978 Oct) Vol.
93, No. 4, pp. 699-703. Journal code: 0375410. ISSN: 0022-3476
Psychiatric and behavioral consequences of
congenital rubella are reported for 243 children studies during the preschool period, and
for 205 of these who were re-examined at ages 8 to 9. At preschool 37% were retarded, with
the skew toward severe and profound; 15% had reactive behavior disorder and 7% had autism.
At school age retardation diminished to 25%, but neurotic problems and behavioral
pathology due to neurologic damage both increased. There were two remissions and three new
instances of autism.
Autistic disorder and viral
infections
Autistic disorder (autism) is a behaviorally defined developmental disorder with a wide
range of behaviors. Although the etiology of autism is unknown, data suggest that autism
results from multiple etiologies with both genetic and environmental contributions, which
may explain the spectrum of behaviors seen in this disorder. One proposed etiology for
autism is viral infection very early in development.
The mechanism, by which viral infection may
lead to autism, be it through direct infection of the central nervous system (CNS),
through infection elsewhere in the body acting as a trigger for disease in the CNS,
through alteration of the immune response of the mother or offspring, or through a
combination of these, is not yet known.
Animal models in which early viral
infection results in behavioral changes later in life include the influenza virus model in
pregnant mice and the Borna disease virus model in newborn Lewis rats. Many studies over
the years have presented evidence both for and against the association of autism with
various viral infections. The best association to date has been made between congenital
rubella and autism; however, members of the herpes virus family may also have a role in
autism.
Recently, controversy has arisen as to the
involvement of measles virus and/or the measles, mumps, rubella (MMR) vaccine in the
development of autism. Biological assays lend support to the association between measles
virus or MMR and autism whereas epidemiologic studies show no association between MMR and
autism. Further research is needed to clarify both the mechanisms whereby viral infection
early in development may lead to autism and the possible involvement of the MMR vaccine in
the development of autism.
Jane E Libbey A1, Thayne L Sweeten A1,
William M McMahon A2, Robert S Fujinami A1
Circulating autoantibodies to
neuronal and glial filament
proteins in autism
Automunumty may be a pathogenic factor in
autism, a behavioral disorder of early childhood onset. Circulating autoantibodies are
produced in organ-specific autoimmunity; therefore, we investigated them in the plasma of
autistic subjects, mentally retarded (MR) subjects, and healthy controls. Autoantibodies
(IgG isotype) to neuron-axon filament protein (anti-NAFP) and glial fibrillary acidic
protein (anti-GFAP) were analyzed by the Western immunoblotting technique. We found a
significant increase in incidence of anti-NAFP (P = .004) and anti-GFAP (P = .002) in
autistic subjects, but not in MR subjects. Clinically, these autoantibodies may be related
to autoimmune pathology in autism.
Vijendra K. Singh PhD, Reed Warren PhD, Rex
Averett MS and Mohammad Ghaziuddin MD. Department of Psychiatry; University of Michigan;,
Ann Arbor, Michigan, USA Center for Persons with Disabilities; Utah State University;,
Logan, Utah, USA
Wakefield AJ, Murch SH, Anthony A, Linnell
J, Casson DM, Malik M, Berelowitz M, Dhillon AP, Thomson MA, Harvey P, Valentine A, Davies
SE, Walker-Smith JA. Ileal-lymphoid-nodular hyperplasia, non-specific colitis, and
pervasive developmental disorder in children. Lancet. 1998 28;351(9103):637-41. PMID:
9500320
Ashwood P et al. Intestinal lymphocyte
populations in children with regressive autism: evidence for extensive mucosal
immunopathology. J Clin Immunol. 2003 Nov;23(6):504-17. PMID: 15031638
Wakefield AJ. Enterocolitis, autism and
measles virus. Mol Psychiatry. 2002;7 Suppl 2:S44-6. PMID: 12142948
Wakefield AJ. The gut-brain axis in
childhood developmental disorders. J Pediatr Gastroenterol Nutr. 2002 May-Jun;34 Suppl
1:S14-7. PMID: 12082381
Wakefield AJ et al. Review article: the
concept of entero-colonic encephalopathy, autism and opioid receptor ligands. Aliment
Pharmacol Ther 2002 16(4):663-74. PMID 11929383
Wakefield AJ et al. Enterocolitis in
children with developmental disorders. Am J Gastroenterol. 2000 Sep;95(9):2285-95. PMID:
11007230
Wakefield AJ, Montgomery SM. Autism, viral
infection and measles-mumps-rubella vaccination. Isr Med Assoc J. 1999 Nov;1(3):183-7.
PMID: 10731332
Wakefield AJ. MMR vaccination and autism.
Lancet. 1999 Sep 11;354(9182):949-50. PMID: 10489978
Overige studies
Torrente F et al. Small intestinal
enteropathy with epithelial IgG and complement deposition in children with regressive
autism. Mol Psychiatry. 2002;7(4):375-82, 334. PMID: 11986981
Furlano RI et al. Colonic CD8 and gamma
delta T-cell infiltration with epithelial damage in children with autism. J Pediatr. 2001
Mar;138(3):366-72. PMID: 11241044
O'Leary JJ et al. Measles virus and autism.
Lancet. 2000 Aug 26;356(9231):772. PMID: 11085720
Quigley EM, Hurley D. Autism and the
gastrointestinal tract. Am J Gastroenterol. 2000 Sep;95(9):2154-6. PMID: 11007210
Kawashima H et al. Detection and sequencing
of measles virus from peripheral mononuclear cells from patients with inflammatory bowel
disease and autism. Dig Dis Sci. 2000 Apr;45(4):723-9. PMID 10759242
Vijendra K. Singh, Ph.D. Autism, Vaccines,
and Immune Reactions. IOM presentation, Feb 9, 2004.
Audio only: http://www.iom.edu/view.asp?id=19132
Singh VK, Jensen RL. Elevated levels of
measles antibodies in children with autism. Pediatr Neurol. 2003 Apr;28(4):292-4. PMID:
12849883
Singh VK et al. Abnormal
measles-mumps-rubella antibodies and CNS autoimmunity in children with autism. J Biomed
Sci. 2002 Jul-Aug;9(4):359-64. PMID 12145534
