Autisme en BMR vaccinatie


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BMR Vaccinatie en autisme - Cryshame

CryShame is a campaigning group co-founded by a number of UK parents and professionals who are concerned about the catastrophic rise in autism spectrum disorders and in the potential link with environmental toxins– particularly MMR and thimerosol (mercury) containing vaccines. CryShame is not an anti-vaccine group. Indeed one of the major factors that brings all co-founding parents of CryShame together is that they all complied with vaccination advice from the department of health in ensuring their children were vaccinated against the recommended range of infectious disease from age 2 months onwards. The immediate mission for CryShame is to support Professor Simon Murch, Dr Andrew Wakefield and Professor Walker-Smith as they stand accused before the General Medical Council of the UK. CryShame additionally supports the democratic rights of scientists and medical practitioners to engage in valid research and to publish relevant findings without fear of prejudice or attack. CryShame exists to tell the story of what brought these doctors to where they are and to bring public attention to the plight of thousands of children worldwide who regressed into autistic-like regression and/or bowel disease following exposure to childhood vaccines.

http://www.cryshame.com/


Autisme opnieuw gelinkt aan BMR vaccinatie

Onderzoekers van de New York University School of Medicine hebben opnieuw aangetoond dat bij 85% van de kinderen met autisme in de darmen vaccin ketens van het mazelvirus zijn aangetroffen. Dit toont opnieuw aan dat de beruchte BMR vaccinatie niet zonder riciso's is. De kinderen in de studie hadden alle serieuze ontstekingen in de darmen.

Deze resultaten zijn een herhaling van studies door Dr Andrew Wakefield in 1998 en patholoog John O'Leary in 2002. Alleen al in de UK zijn er meer dan 2000 ouders die zeggen dat hun kind normaal ontwikkelden tot het moment van de BMR vaccinatie.

Zal er iets veranderen? Ik ben bang van niet. Zoals met andere zaken zoals aspartaam, gsm, dect, chemische toevoegingen aan eten, aluminium in deo, gentech voedsel zijn er altijd weer wetenschappers die dit stelselmatig gaan ontkennen om het volk te sussen en hopen dat het weer overwaait. Adviseurs van onze overheid hebben meestal dubbele agenda's en belangen in de pharma business. Ook gaat het groter belang (vaccinatiebeleid) voor een kleine groep kwetsbare kinderen die een slecht ontwikkeld immuunsysteem hebben en de rekening daarvoor betalen.

Mijn zoon Vincent ontwikkelde ook prima tot het moment dat hij die vervloekte BMR vaccinatie krijg. Twee dagen erna werd hij doodziek en moest in Zeist naar de kinderarts. Er werd een kweek gemaakt maar die raakte "kwijt" dus hebben we nooit een uitslag gehad. Hierna veranderde zijn gedrag sterk en zat ik een jaar later op de afdeling kinderpsychiatrie van het UMC en kreeg de diagnose "stoornis in het autistisch spectrum" en "ontwikkelachterstand". Geen van beide zaken komen in de familie van de ouders voor.

Toen ik het moment van de BMR vaccinatie noemde werd dit minachtend van tafel geveegd. Die arrogantie zie je keer op keer terugkomen. Ook mensen met de ziekte ME zijn jarenlang behandeld als was het een psychische aandoening. Ondanks voldoende bewijs dat er fysieke oorzaken waren bleef men te arrogant om hun ongelijk toe te geven.

Ron


Dr Richard Halverson How dangerous is measles

Dr Richard Halvorsen answers the big questions about MMR, Vaccines and Diseases


New study confirms measles virus in bowels of autistic children

A study due to be presented June 1st-3rd at the International Meeting for Autism Research (IMFAR), in Montreal, Canada, has confirmed the finding of a link between the measles virus in MMR vaccine with childhood autism.

What has this study found?

This study has confirmed the original UK/Irish findings of measles virus in the inflamed intestinal tissues of children with autism.
This study confirms that in the examined cases, MMR vaccine is the source of the measles virus.

http://www.thoughtfulhouse.org/pr/053106.htm


Study identifies association between pattern of MMR exposure and regressive autism

"Is There a 'Regressive Phenotype' of Autism Spectrum Disorder Associated with the Measles-Mumps-Rubella Vaccine? A CPEA Study"; Richler J et al. Journal of Autism and Developmental Disorders. 2006; April 28.

A recent multi-center Collaborative Programs of Excellence in Autism (CPEA) study examined:
(i) whether there is a regressive phenotype of autism;
(ii) whether this phenotype is associated with gastrointestinal symptoms; and,
(iii) whether this phenotype is associated with exposure to the MMR vaccine.

One of the more compelling observations to emerge from this study was a clear association between significant gastrointestinal symptoms and regressive autism, compared with children who exhibited features of autism from an early age. Of particular interest is the observation of an association between children with the 'regressive phenotype', age of onset of regression, and age of MMR vaccination.

The authors defined the children of interest - the 'regressive' phenotype - as those with normal or near normal skills before MMR vaccination who regressed after MMR vaccination and who had had at least one gastrointestinal symptom for three consecutive months at some point in his or her life.

When these children were compared with the remaining autistic group, there was a statistically significant difference in the sex ratio (more females in the phenotype group); significantly later age of onset in the phenotype group (a mean of 19 months compared with 14.55 months) and lower age at MMR vaccination (14.38 months versus 17.71 months).

The later observation is particularly interesting in view of the fact that age of exposure to measles virus is a major determinant of the risk of an adverse outcome. Children exposed to measles early in life are at greater risk of persistent (long-term) infection and delayed neurologic disease. This risk diminishes as children get older. Persistent infection with measles virus in children with regressive autism has been reported by Thoughtful House scientists and replicated in a study that is due to be presented at the International Meeting for Autism Research (IMFAR) in Montreal June 1-3.

The observation in the current paper that younger age at MMR vaccination is associated with regressive autism in children with intestinal symptoms is therefore entirely consistent with an adverse outcome from MMR vaccine.
It is most surprising that, in view of their findings, the authors conclude in the paper’s abstract that "there was no evidence that onset of autistic symptoms or of regression was related to measles-mumps-rubella vaccination." Further clarification of this apparently irreconcilable contradiction is being sought from the authors of the study.

http://www.thoughtfulhouse.org/comm/051606.htm


Detection of Measles Virus Genomic RNA in Cerebrospinal Fluid of Children with Regressive Autism: a Report of Three Cases

Findings are consistent with both an MV etiology for the AE and
active viral replication in these children. They further indicate the
possibility of a virally driven cerebral immunopathology in some
cases of regressive autism. A possible association betweenMMRvaccination and autistic encephalopathic regression (AE) in previously developmentally
normal children has been reported.

http://www.jpands.org/vol9no2/bradstreet.pdf


Abnormal Measles-Mumps-Rubella Antibodies and CNS Autoimmunity in Children with Autism

It is quite possible that vaccines in a small population of genetically predisposed children may react inappropriately, simply because of their immature immune system or some other unknown risk factors such as immunodeficiencies, allergies, chemical toxins or chronic psychological stress. However, none of these factors has so far been investigated in autism. In recent years, the immunization-autoimmunity topic has gained quite a bit of public attention. This is quite possibly because autoimmune diseases are the commonest manifestations of immunizations. The MMR has been insinuated as a culprit of gastrointestinal problems in some children with autistic characteristics. Approximately one half of the parents with autistic children reported autistic regression after the MMR immunization

http://content.karger.com/ProdukteDB/produkte.asp?Aktion=Show
PDF&ProduktNr=224259&ArtikelNr=65007&filename=65007.pdf


Abnormal Measles-Mumps-Rubella Antibodies and CNS Autoimmunity in Children with Autism

Autoimmunity to the central nervous system (CNS), especially to myelin basic protein (MBP), may play a causal role in autism, a neurodevelopmental disorder. Because many autistic children harbor elevated levels of measles antibodies, we conducted a serological study of measles-mumps-rubella (MMR) and MBP autoantibodies. Using serum samples of 125 autistic children and 92 control children, antibodies were assayed by ELISA or immunoblotting methods. ELISA analysis showed a significant increase in the level of MMR antibodies in autistic children. Immunoblotting analysis revealed the presence of an unusual MMR antibody in 75 of 125 (60%) autistic sera but not in control sera. This antibody specifically detected a protein of 73-75 kD of MMR. This protein band, as analyzed with monoclonal antibodies, was immunopositive for measles hemagglutinin (HA) protein but not for measles nucleoprotein and rubella or mumps viral proteins. Thus the MMR antibody in autistic sera detected measles HA protein, which is unique to the measles subunit of the vaccine. Furthermore, over 90% of MMR antibody-positive autistic sera were also positive for MBP autoantibodies, suggesting a strong association between MMR and CNS autoimmunity in autism. Stemming from this evidence, we suggest that an inappropriate antibody response to MMR, specifically the measles component thereof, might be related to pathogenesis of autism.

Author:

Vijendra Singh, PhD
Biotechnology Center
Utah State University
4700 Old Main Hill, Logan, UT 84322 (USA)
Tel. +1 435 797 7193
Fax +1 435 797 2766
EMail singhvk@cc.usu.edu

http://content.karger.com/ProdukteDB/produkte.asp?
Aktion=ShowAbstract&ProduktNr=224259&ArtikelNr=65007


Behavioral consequences of congenital rubella.

Chess S; Fernandez P; Korn S

The Journal of pediatrics, (1978 Oct) Vol. 93, No. 4, pp. 699-703. Journal code: 0375410. ISSN: 0022-3476

Psychiatric and behavioral consequences of congenital rubella are reported for 243 children studies during the preschool period, and for 205 of these who were re-examined at ages 8 to 9. At preschool 37% were retarded, with the skew toward severe and profound; 15% had reactive behavior disorder and 7% had autism. At school age retardation diminished to 25%, but neurotic problems and behavioral pathology due to neurologic damage both increased. There were two remissions and three new instances of autism.


Autistic disorder and viral infections

Autistic disorder (autism) is a behaviorally defined developmental disorder with a wide range of behaviors. Although the etiology of autism is unknown, data suggest that autism results from multiple etiologies with both genetic and environmental contributions, which may explain the spectrum of behaviors seen in this disorder. One proposed etiology for autism is viral infection very early in development.

The mechanism, by which viral infection may lead to autism, be it through direct infection of the central nervous system (CNS), through infection elsewhere in the body acting as a trigger for disease in the CNS, through alteration of the immune response of the mother or offspring, or through a combination of these, is not yet known.

Animal models in which early viral infection results in behavioral changes later in life include the influenza virus model in pregnant mice and the Borna disease virus model in newborn Lewis rats. Many studies over the years have presented evidence both for and against the association of autism with various viral infections. The best association to date has been made between congenital rubella and autism; however, members of the herpes virus family may also have a role in autism.

Recently, controversy has arisen as to the involvement of measles virus and/or the measles, mumps, rubella (MMR) vaccine in the development of autism. Biological assays lend support to the association between measles virus or MMR and autism whereas epidemiologic studies show no association between MMR and autism. Further research is needed to clarify both the mechanisms whereby viral infection early in development may lead to autism and the possible involvement of the MMR vaccine in the development of autism.

Jane E Libbey A1, Thayne L Sweeten A1, William M McMahon A2, Robert S Fujinami A1

http://taylorandfrancis.metapress.com/(mevlwnq1c3hj4p45wpdgh
345)/app/home/contribution.asp?referrer=parent&backto=issue,
1,15; journal,7,34;linkingpublicationresults,1:100968,1


Circulating autoantibodies to neuronal and glial filament
proteins in autism

Automunumty may be a pathogenic factor in autism, a behavioral disorder of early childhood onset. Circulating autoantibodies are produced in organ-specific autoimmunity; therefore, we investigated them in the plasma of autistic subjects, mentally retarded (MR) subjects, and healthy controls. Autoantibodies (IgG isotype) to neuron-axon filament protein (anti-NAFP) and glial fibrillary acidic protein (anti-GFAP) were analyzed by the Western immunoblotting technique. We found a significant increase in incidence of anti-NAFP (P = .004) and anti-GFAP (P = .002) in autistic subjects, but not in MR subjects. Clinically, these autoantibodies may be related to autoimmune pathology in autism.

Vijendra K. Singh PhD, Reed Warren PhD, Rex Averett MS and Mohammad Ghaziuddin MD. Department of Psychiatry; University of Michigan;, Ann Arbor, Michigan, USA Center for Persons with Disabilities; Utah State University;, Logan, Utah, USA

http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=
B6TBD-3RJGTYN-J&_coverDate=07%2F31%2F1997&_alid=
414748852&_rdoc=1&_fmt=&_orig=search&_qd=1&_cdi=5140
&_sort=d&view=c&_acct=C000050221&_version=1&_url
Version=0&_userid=10&md5=a092502a7c83d3925dc1d86598cc387b


Meer studies


Studies Door AJ Wakefield

Wakefield AJ, Murch SH, Anthony A, Linnell J, Casson DM, Malik M, Berelowitz M, Dhillon AP, Thomson MA, Harvey P, Valentine A, Davies SE, Walker-Smith JA. Ileal-lymphoid-nodular hyperplasia, non-specific colitis, and pervasive developmental disorder in children. Lancet. 1998 28;351(9103):637-41. PMID: 9500320

Ashwood P et al. Intestinal lymphocyte populations in children with regressive autism: evidence for extensive mucosal immunopathology. J Clin Immunol. 2003 Nov;23(6):504-17. PMID: 15031638

Wakefield AJ. Enterocolitis, autism and measles virus. Mol Psychiatry. 2002;7 Suppl 2:S44-6. PMID: 12142948

Wakefield AJ. The gut-brain axis in childhood developmental disorders. J Pediatr Gastroenterol Nutr. 2002 May-Jun;34 Suppl 1:S14-7. PMID: 12082381

Wakefield AJ et al. Review article: the concept of entero-colonic encephalopathy, autism and opioid receptor ligands. Aliment Pharmacol Ther 2002 16(4):663-74. PMID 11929383

Wakefield AJ et al. Enterocolitis in children with developmental disorders. Am J Gastroenterol. 2000 Sep;95(9):2285-95. PMID: 11007230

Wakefield AJ, Montgomery SM. Autism, viral infection and measles-mumps-rubella vaccination. Isr Med Assoc J. 1999 Nov;1(3):183-7. PMID: 10731332

Wakefield AJ. MMR vaccination and autism. Lancet. 1999 Sep 11;354(9182):949-50. PMID: 10489978

Overige studies

Torrente F et al. Small intestinal enteropathy with epithelial IgG and complement deposition in children with regressive autism. Mol Psychiatry. 2002;7(4):375-82, 334. PMID: 11986981

Furlano RI et al. Colonic CD8 and gamma delta T-cell infiltration with epithelial damage in children with autism. J Pediatr. 2001 Mar;138(3):366-72. PMID: 11241044

O'Leary JJ et al. Measles virus and autism. Lancet. 2000 Aug 26;356(9231):772. PMID: 11085720

Quigley EM, Hurley D. Autism and the gastrointestinal tract. Am J Gastroenterol. 2000 Sep;95(9):2154-6. PMID: 11007210

Kawashima H et al. Detection and sequencing of measles virus from peripheral mononuclear cells from patients with inflammatory bowel disease and autism. Dig Dis Sci. 2000 Apr;45(4):723-9. PMID 10759242

Vijendra K. Singh, Ph.D. Autism, Vaccines, and Immune Reactions. IOM presentation, Feb 9, 2004.
Audio only: http://www.iom.edu/view.asp?id=19132

Singh VK, Jensen RL. Elevated levels of measles antibodies in children with autism. Pediatr Neurol. 2003 Apr;28(4):292-4. PMID: 12849883

Singh VK et al. Abnormal measles-mumps-rubella antibodies and CNS autoimmunity in children with autism. J Biomed Sci. 2002 Jul-Aug;9(4):359-64. PMID 12145534

 

 

 


 


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