Wereldwijd slikken miljoenen mensen
antidepressiva zonder ooit goed over de bijwerkingen te zijn voorgelicht. Het internet
staat volgeschreven met ervaringen van gebruikers en de door hen geconstateerde
bijwerkingen. Ervaringen die je op de bijsluiters niet of te cryptisch omschreven terug
vindt.
Veel op het internet beschreven ervaringen
betreffen: verslaving aan het middel en dus moeilijk kunnen afbouwen, dik worden en
impotentie. Uit onderzoek van het gerenommeerde Cochrane instituut blijkt dat het nemen
van het voedingssupplement St. Janskruid net zo effectief kan werken als antidepressiva
zonder al die bijwerkingen. Uit het onderzoek komt tevens naar voren dat omega 3 vetzuren
een cruciale rol kunnen spelen bij depressie.
De inname van teveel linolzuur (omega 6
vetzuur), kenmerkend voor westerse voedingspatronen, kan de opname van omega 3 verstoren
en daarmee negatief bijdrage aan depressie. Een ander gevolg van een teveel aan linolzuur
zijn ontstekingen. Sommige theorieën stellen dat juist kleine ontstekingen aan depressie
ten grondslag kunnen liggen. Omega 3 is een ontstekingsremmer en daarmee is de cirkel
rond. Een alternatief op het slikken van antidepressiva is het nemen van St. Janskruid,
het beperken van inname van linolzuur en het opvoeren van de inname van omega3. Lees ook
een het stukje over Curcuma (Geelwortel) (Link)
Bijwerkingen van antidepressiva:
- Zelfmoord onder jongeren
- Kwaliteitsverlies sperma
- Hartafwijkingen bij de ongeboren vrucht
- Neurologische schade
- Verstoord gedrag in het verkeer
- Maagbloedingen
- Verhoogde kans op diabetes 2
- Overgewicht
- Botverlies (o.a. Prozac, Paxil en Zolof)
Aan deze site wordt door diverse
vrijwilligers bijdragen. Wie is in staat het Engelstalige stuk in het Nederlands te
vertalen? Interesse ...emailen
Ron
Sint Janskuid veilig en minder
bijwerkingen dan anti-depressiva
De Cochrane analyse van sint Janskruid was
anno 2008 zeer positief [4], de hoofdonderzoeker Klaus Linde merkte in een interview op
dat: Uiteindelijk ontdekten we dat de Sint Janskruid extracten die in de studies waren
gebruikt superieur waren tov placebo's en net zo effectief waren als standaard
antidpressiva's, echter zijn de nadelige bijwerkingen daarvan aldus hoofdonderzoeker Klaus
Linde (Centre for Complementary Medicine Muenchen, Duitsland).
In de Cochrane analyse stond het ook klip
en klaar: even effectief als reguliere middelen, maar minder bijwerkingen! Wie meende in
Nederland dat alternatieven niet werkzaam zijn??? We citeren:
The available evidence suggests that the
hypericum extracts tested in the included trials
a) are superior to placebo in patients with
major depression;
b) are similarly effective as standard antidepressants;
c) and have fewer side effects than standard antidepressants.
Referenties
[1]: Zhou S, Chan E, Pan SQ, Huang M, Lee EJ. | Pharmacokinetic interactions of drugs with
St John's wort. | J Psychopharmacol. | 2004 Jun;18(2):262-76.
[2]: Mannel M. | Drug interactions with St John's wort : mechanisms and clinical
implications. | Drug Saf. | 2004;27(11):773-97.
[3]: Mischoulon D. | Update and critique of natural remedies as antidepressant treatments.
| Psychiatr Clin North Am. | 2007 Mar;30(1):51-68.
[4]: Linde K, Berner MM, Kriston L. | St John's wort for major depression. | Cochrane
Database Syst Rev. | 2008 Oct 8;(4):CD000448.
Bron: IOCOB en Ronfonteine.com
Serotonine-syndroom ook bij
nieuwste anti-depressiva
Het serotoninesyndroom is een bijwerking
van antidepressiva die levensbedreigende gevolgen kan hebben. Het syndroom kan optreden
bij gebruik van ssri’s, de oudere mao-remmers en bij tricyclische antidepressiva.
Volgens Yener Güzelcan, psychiater bij Riagg Rijnmond, komt het syndroom ook voor bij de
nieuwste generatie antidepressiva.
Het serotoninesyndroom is een ernstige,
potentieel levensbedreigende bijwerking van stoffen met een serotonerge werking. De
symptomen kunnen worden verdeeld in drie clusters:
Er bestaan een groot aantal medicijnen die
overgewicht veroorzaken. U zult dat echter niet direct in de bijsluiter vermeldt zien.
Seroxat (Paroxetine) en Remeron (Mirtazapine), beide anti-depressiva veroorzaken vaak
overgewicht.
Antidepressant activity of aqueous extracts
of Curcuma longa in mice
These results demonstrated that C. longa
had specifically antidepressant effects in vivo. The activity of C. longa in
antidepression may mediated in part through MAO A inhibition in mouse brain.
Laaggradige ontsteking oorzakelijke
factor bij veel ziektebeelden
Wetenschappelijk onderzoek wijst nu ook in
de richting van een oorzakelijke rol van ontsteking bij atherosclerose, kanker, diabetes
mellitus, de ziekte van Alzheimer, osteoporose, slapeloosheid en depressie. Het gaat dan
om een laaggradige ontsteking die daardoor niet gepaard gaat met de klassieke
ontstekingssymptomen.
In ons land slikken bijna 1 miljoen mensen
antidepressiva. De laatste jaren is uit meerdere onderzoeken gebleken dat veel mensen met
een lichte of matige depressie de pillen helemaal niet nodig hebben. Artsen weten dit wel,
maar schreven het afgelopen jaar toch meer dan 6 miljoen recepten uit. Ze hebben vaak geen
tijd voor een goed gesprek met de patiënt, terwijl dat volgens deskundigen voor
depressieve mensen de oplossing zou kunnen zijn. De deskundigen zeggen dat voor veel
mensen de depressie na een paar maanden ook vanzelf overgaat. De nieuwe antidepressiva
zijn niet de wondermiddelen waarvoor ze twintig jaar geleden werden aangezien. De
bijwerkingen kunnen ernstig zijn, ze doen niet altijd wat ze beloven en soms treden er na
het stoppen of minderen met de pillen ontwenningsverschijnselen op. In Zembla twee
patiënten die over hun antidepressiva-gebruik vertellen.
Anti-depressiva te vaak en te veel
voorgeschreven. Meer dan honderdduizend Nederlanders slikken meer anti-depressiva dan
gezond is. Niet alleen werkt een hogere dosis niet, de pillen geven ook meer bijwerkingen.
Dat concludeert psychiater Eric Ruhé van het AMC in Amsterdam die volgende week
promoveert op een onderzoek naar paroxetine (Seroxat) en fluoxetine (Prozac). Vooral het
verdubbelen van de dosis nadat een eerste dosis geen effect had is volgens hem schadelijk
en heeft geen effect. Uit hersenscans blijkt dat de extra werkzame stof geen verandering
teweegbrengt. In Nederland slikken 800.000 mensen anti-depressiva. In EénVandaag een
gesprek met Ruhé en Ivan Wolffers, arts en schrijver.
Luister dit interview en besef met welk een
onmensen wij te maken hebben die nota bene beweren het goed met ons voor te hebben.
Tientallen tot honderden doden zouden er vallen omdat mensen bang zijn om hun kinderen
pillen te geven. Op de vraag waar de cijfers vandaan komen aan de zogenaamde wetenschapper
stelt hij; "Meent U dat het zonder cijfers in de krant gekomen was"
An excerpt from the feature-documentary
'Generation RX.' The film discusses a pattern of collusion between drug
manufacturers and their regulatory watchdogs at the FDA - of evidence hidden from the
general public, despite the risks being well-known long before antidepressant drugs were
approved for the marketplace.
Description: A new study suggests that
about a quarter of the people who have been diagnosed with depression may actually be
dealing with the normal and expected emotions associated with loss or traumatic events.
eports have surfaced that the accused
murderer of 33 people at Virginia Tech was briefly under medical care for depression. So
the question naturally arises: was he taking SSRI antidepressants? Prozac? Zoloft? Paxil?
These drugs are known to cause suicides and murders. That is, the person taking them kills
himself or others. Glaxo, the maker of Paxil, has been under the gun for some time now,
because it knew Paxil had problems and concealed those problems from the FDA and doctors
and the public.
Description: The results of a major review
of published research that examined the relationship between depression and level of
omega-3 fatty acids in the diet suggest that omega-3 fatty acids have antidepressant
effects. However, the researchers point out that the quality of the studies means it's
still too soon to say definitively that omega-3s can treat depression or bipolar disorder.
Antidepressants linked with
suicidal thoughts in under 25
Antidepressants may raise the risk of
suicidal behavior in those under the age of 25, according to a report from the Food and
Drug Administration. Although the risk is already acknowledged among children and
teenagers, the FDA has been studying the risk in adults. The analysis, published ahead of
an advisory panel meeting next week, reported the effect in patients up to the age of 25.
Novel treatment strategies for major
depression with broader treatment success or a more rapid onset of action would have
immense impact on public health, a new study published in the Dec. 1 issue of Biological
Psychiatry explains.
Antidepressants, Bipolar Disorder
and the Chemical Enslavement of Humankind by Drug Companies
Big Pharma is constantly looking for new
ways to develop its markets and generate more profits. This is the inescapable directive
of all corporations: Be more profitable, regardless of the cost to society. In Big
Pharma's case, the pursuit of this mission inevitably leads to the targeting of an
ever-increasing selection of pharmaceutical consumers who have the potential to become
lifelong customers.
Antidepressants don't work as well
as reported, study says
New England Journal of Medicine reports
that 88 per cent of clinical trials that showed the drugs didn't work either weren't
published in medical journals or were presented as positive findings
Is transcranial magnetic
stimulation a new treatment of Bulimia Nervosa?
A group of investigators of the Innsbruck
University (Austria) reports on a new modality of treatment for bulimia nervosa,
transcranial magnetic stimulation, in the 2008 January issue of Psychotherapy and
Psychosomatics. Transcranial magnetic stimulation is a non-invasive, neurophysiological
method, which affects cortical neurons with a short magnetic pulse. Bulimia nervosa (BN)
is often associated with depressive symptoms and treatment with antidepressants has shown
positive effects. A shared deficient serotonergic transmission was postulated for both
syndromes. The left dorsolateral prefrontal cortex was argued to regulate eating behaviour
and to be dysfunctional in eating disorders.
Some antidepressants associated
with gastrointestinal bleeding
A class of antidepressants known as
selective serotonin reuptake inhibitors (SSRIs) appear to be associated with bleeding in
the upper gastrointestinal tract, according to a report in the July issue of Archives of
General Psychiatry, one of the JAMA/Archives journals. The effects appear increased when
antidepressants are combined with other stomach-harming medications and decreased when
acid-suppressing agents are used.Since the early 1990s, case reports have suggested an
association between SSRIs and bleeding in the upper gastrointestinal (GI) tract, according
to background information in the article. "The wide use of this drug class requires
research to provide more accurate risk estimates, to identify factors that may further
increase the risk and, in particular, to determine whether using acid-suppressing agents
may reduce the risk," the authors write. "It is also important to determine
whether venlafaxine hydrochloride, a new antidepressant related to SSRIs, also increases
the risk of bleeding, as some individual case reports have suggested."
N.Y. research team discovers how
antidepressants and cocaine interact with brain cell targets
In a first, scientists from Weill Cornell
Medical College and Columbia University Medical Center have described the specifics of how
brain cells process antidepressant drugs, cocaine and amphetamines. These novel findings
could prove useful in the development of more targeted medication therapies for a host of
psychiatric diseases, most notably in the area of addiction.
Medication increasingly replaces
psychotherapy, study finds
Fewer patients are undergoing in-depth
treatment as antidepressants and other drugs are more widely used. The shift is attributed
partly to insurance reimbursement policies.
Antidepressants May Impair Driving
Ability, New Research Finds
People taking prescription antidepressants
appear to drive worse than people who aren't taking such drugs, and depressed people on
antidepressants have even more trouble concentrating and reacting behind the wheel. These
were the conclusions of a study released Sunday at the Annual Convention of the American
Psychological Association. University of North Dakota psychologists Holly Dannewitz. PhD,
and Tom Petros, PhD, recruited 60 people to participate in a driving simulation in which
participants had to make a series of common driving decisions, such as reacting to brake
lights, stop signs or traffic signals while being distracted by speed limit signs, pylons,
animals, other cars, helicopters or bicyclists. The simulation tested steering,
concentration and scanning. Thirty-one of the participants were taking at least one type
of antidepressant while 29 control group members were taking no medications with the
exception of oral contraceptives in some cases. The group taking antidepressants was
further divided into those who scored higher and lower on a test of depression. The group
taking antidepressants who reported a high number of symptoms of depression performed
significantly worse than the control group on several of the driving performance tasks.
But participants who were taking antidepressants and scored in the normal range on a test
to measure depression performed no differently than the non-medicated individuals.
Sex differences seen in response to
common antidepressant
Women with depression may be much more
likely than men to get relief from a commonly used, inexpensive antidepressant drug, a new
national study finds. But many members of both sexes may find that it helps ease their
depression symptoms. The persistence of a gender difference in response to the drug —
even after the researchers accounted for many complicating factors — suggests that
there’s a real biological difference in the way the medication affects women compared
with men. The reasons for that difference are still unclear, but further studies are now
examining hormonal variations that may play a role. The study involved citalopram, a
commonly used antidepressant that is available both as a generic drug and under the brand
name Celexa.
Antidepressants need new nerve
cells to be effective, researchers find
Researchers at UT Southwestern Medical
Center have discovered in mice that the brain must create new nerve cells for either
exercise or antidepressants to reduce depression-like behavior. In addition, the
researchers found that antidepressants and exercise use the same biochemical pathway to
exert their effects. These results might help explain some unknown mechanisms of
antidepressants and provide a new direction for developing drugs to treat depression, said
Dr. Luis Parada, chairman of developmental biology and senior author of a study in the
Aug. 14 issue of the journal Neuron. In animals, it was already known that long-term
treatment with antidepressants causes new nerve cells to be generated in a part of the
brain called the dentate gyrus. Exercise, which can also relieve the symptoms of
depression, stimulates the generation of new nerve cells in the same area. "We would
never claim that what we study in mice directly relates to how antidepressants work in
humans, but there are interesting features in parallel," Dr. Parada said. "The
study unifies different observations that point to the brain’s dentate gyrus region
and to creation of nerve cells as being important in depression." Antidepressants act
very quickly to increase levels of natural compounds, called neurotransmitters, which
nerve cells use to communicate. It takes several weeks to several months, however, for the
patients who respond to such treatments to feel less depressed. Dr. Parada said this
implies that some other long-term mechanism is also at work.
Exercise stimulates the formation
of new brain cells
Exercise has a similar effect to
antidepressants on depression. This has been shown by previous research. Now Astrid
Bjørnebekk at Karolinska Institutet has explained how this can happen: Exercise
stimulates the production of new brain cells.
OHSU scientists find
antidepressant, bone loss link
Two new studies suggest older men and women
taking selective serotonin reuptake inhibitors, a class of antidepressants that includes
Prozac, Paxil and Zoloft, are prone to increased bone loss. The jointly released studies
by scientists at Oregon Health & Science University, and in San Francisco,
Minneapolis, San Diego and Pittsburgh, found that elderly men taking SSRIs had lower bone
mineral density, and elderly women taking the antidepressants had a higher rate of yearly
bone loss.
The Increasing Use Of
Antidepressants: Some Reasons For Concern
Two articles in the March issue of the
European Journal Psychotherapy and Psychosomatics raise serious concern about the
increasing use of antidepressant medications. In the first article, David Healy and
collaborators (University of Cardiff) formulate a critique of many studies which try to
support the use of antidepressants on the basis of variations in suicide rates. The
Authors compare suicide rates in the Nordic countries with autopsy and ill-defined death
rates, and antidepressant sales, during the period 1961 through to 2003, finding a close
correlation between suicide rates and both autopsy and ill-defined death rates.The Authors
conclude that the role of autopsies and other factors in the registration of a death as a
suicide appear to need further clarification.
A link between antidepressants and
type 2 diabetes
University of Alberta researcher Lauren
Brown has found people with depression are at an increased risk of developing type 2
diabetes. Brown's results discovered the risk of diabetes almost doubled for those who
were taking a combination of antidepressants.
As antidepressants start working,
hopelessness lingers
People taking medication for depression
typically see a lot of improvements in their symptoms during the first few months, but
lagging behind other areas is a sense of hopefulness, according to new research from the
University of Michigan Health System
Antidepressant Drugs Work No Better
than Placebo; Big Pharma Hoax Finally Exposed
This study is sending shockwaves through
the medical community. It finally reveals the Big Pharma hoax behind antidepressant drugs.
Through fraudulent science and clever marketing, drug companies have managed to take a
drug that works no better than placebo and turn it into a multi-billion dollar scam. But
the truth is finally out: Taking Prozac is no more effective than taking a sugar pill!
Hundreds of millions of consumers have been fooled by the quack science supporting modern
pharmaceutical medicine.
Initial Severity and Antidepressant
Benefits - A Meta-Analysis of Data Submitted to the Food and Drug Administration
These findings suggest that, compared with
placebo, the new-generation antidepressants do not produce clinically significant
improvements in depression in patients who initially have moderate or even very severe
depression, but show significant effects only in the most severely depressed patients. The
findings also show that the effect for these patients seems to be due to decreased
responsiveness to placebo, rather than increased responsiveness to medication. Given these
results, the researchers conclude that there is little reason to prescribe new-generation
antidepressant medications to any but the most severely depressed patients unless
alternative treatments have been ineffective. In addition, the finding that extremely
depressed patients are less responsive to placebo than less severely depressed patients
but have similar responses to antidepressants is a potentially important insight into how
patients with depression respond to antidepressants and placebos that should be
investigated further.
80 Percent of Suicide Victims Took
Antidepressant Drugs
Swedish writer has accused the National
Board of Health and Welfare (NBHW) of covering up evidence suggesting a connection between
psychiatric drugs and suicide. Under a recent law, Swedish health-care providers must fill
out reports on all suicides committed by patients under their care or within four weeks of
a health care visit. The reports are then sent to the NBHW, which compiles and analyzes
them.
Researchers Find a Bias Toward
Upbeat Findings on Antidepressants
The makers of antidepressants like Prozac
and Paxil never published the results of about a third of the drug trials that they
conducted to win government approval, misleading doctors and consumers about the drugs'
true effectiveness, a new analysis has found.
Without the ability to cope, a lobotomy
would surely open the doors to all kinds of craziness from the nastiness in the
world....depression, suicide, and murder become a reality...And this is exactly what an
SSRI (antidepressant) can potentially do at the molecular level - remove that portion of
your brain that helps you cope.
Marijuana-like brain chemicals work
as antidepressant
American and Italian researchers have found
that boosting the amounts of a marijuana-like brain transmitter called anandamide produces
antidepressant effects in test rats.
Nearly a decade has passed since Prozac,
the antidepressant drug, was introduced to themarket and quickly achieved the label of a
"wonder drug." During that time,Prozac has indeed helped many people who suffer
from severe depression. But the earlyclaims that Prozac would alleviate depression without
causing harmful side effects havenot been realized. Indeed, just the opposite has proven
to be true. Prozac has produced serious sideeffects in some users, prompting a host of
lawsuits against Eli Lilly & Co., thedrug's manufacturer. These adverse effectsinclude
akathisia (a condition in which a person feels compelled to move about), permanent
neurological damage, and suicidal obsession and acts of violence.
Serotonin and Depression: A
Disconnect between the Advertisements and the Scientific Literature
Serotonine en depressie - een breuk tussen
wetenschappelijke literatuur en advertenties
The impact of the widespread promotion of
the serotonin hypothesis should not be underestimated. Antidepressant advertisements are
ubiquitous in American media, and there is emerging evidence that these advertisements
have the potential to confound the doctor–patient relationship. A recent study by
Kravitz et al. found that pseudopatients (actors who were trained to behave as patients)
presenting with symptoms of adjustment disorder (a condition for which antidepressants are
not usually prescribed) were frequently prescribed paroxetine (Paxil) by their physicians
if they inquired specifically about Paxil [45]; such enquiries from actual patients could
be prompted by DTCA [45].
What remains unmeasured, though, is how
many patients seek help from their doctor because antidepressant advertisements have
convinced them that they are suffering from a serotonin deficiency. These advertisements
present a seductive concept, and the fact that patients are now presenting with a
self-described "chemical imbalance" [46] shows that the DTCA is having its
intended effect: the medical marketplace is being shaped in a way that is advantageous to
the pharmaceutical companies. Recently, it has been alleged that the FDA is more
responsive to the concerns of the pharmaceutical industry than to their mission of
protecting US consumers, and that enforcement efforts are being relaxed [47]. Patients who
are convinced they are suffering from a neurotransmitter defect are likely to request a
prescription for antidepressants, and may be skeptical of physicians who suggest other
interventions, such as cognitive-behavioral therapy [48], evidence-based or not. Like
other vulnerable populations, anxious and depressed patients "are probably more
susceptible to the controlling influence of advertisements" [49].
In 1998, at the dawn of consumer
advertising of SSRIs, Professor Emeritus of Neuroscience Elliot Valenstein summarized the
scientific data by concluding, "What physicians and the public are reading about
mental illness is by no means a neutral reflection of all the information that is
available" [50]. The current state of affairs has only confirmed the veracity of this
conclusion. The incongruence between the scientific literature and the claims made in
FDA-regulated SSRI advertisements is remarkable, and possibly unparalleled.
Antidepressants and painkillers - a
dangerous combination
Taking antidepressants together with
painkillers can substantially increase the risk of bleeding from the stomach, according to
new research by the University of East Anglia.
Anti-depressiva kunnen
hartafwijkingen bij baby veroorzaken
Pregnancy study finds strong association
between two antidepressants and heart anomalies
Three-country study looks at fluoxetine and
paroxetine
Women who took the antidepressant
fluoxetine during the first three months of pregnancy gave birth to four times as many
babies with heart problems as women who did not and the levels were three times higher in
women taking paroxetine. Although some of the conditions were serious, others were not
severe and resolved themselves without the need for medical intervention, according to a
three-country study in the November issue of the British Journal of Clinical Pharmacology.
Researchers have advised women taking the drugs to continue unless they are advised to
stop by their doctor or consultant. But they are being urged to give up smoking, as the
study also found that more than ten cigarettes a day was associated with a five-fold
increase in babies with major heart problems. The team has also suggested that women on
fluoxetine should be given a foetal echocardiogram in their second trimester to diagnose
possible heart anomalies. International researchers from Israel, Italy and Germany
followed the pregnancies of 2,191 women - 410 who had taken paroxetine during pregnancy,
314 who had taken fluoxetine and 1,467 controls who hadn't taken either of the drugs.
"After we excluded genetic and cytogenic anomalies, we found a higher rate of major
heart anomalies in the women who had been taking the antidepressants" says lead
author Professor Asher Ornoy from the Israeli Teratology Information Service in Jerusalem,
Israel. "Further analysis showed a strong association between major heart anomalies
and taking fluoxetine in the first trimester. Women who smoked more than 10 cigarettes a
day also had more babies with heart anomalies."
FDA: Infant Deaths From
Antidepressants (MOTHERS Act)
FDA's Medwatch Adverse Events Reporting
System contains reports of hundreds of babies killed and born with life-threatening birth
defects during the past 4 years. The FDA admits only 1-10% of drug side effects are ever
reported. Stop The MOTHERS Act
