Aging - gezond ouder worden
The sweet truth - Ditch sugar to look
ten years younger
In a nutshell, sugar hastens the degradation of elastin and collagen, both key skin
proteins. In other words, it actively ages you," says Dr Brandt, who counts Madonna,
Rupert Everett, Cher and Ellen Barkin among his clients.
http://www.dailymail.co.uk/pages/live/femail/article.html?in_
article_id=461095&in_page_id=1879
Researchers at Illinois explore queen
bee longevity
The researchers knew from studies of the fruit fly and nematode that the
insulin-signaling pathway had a role in longevity. Down-regulation of insulin-IGF-1
signaling (IIS) in those species was associated with increases in longevity - but at the
expense of fertility. They also knew that manipulating fat body cells in the head of the
fruit fly influenced longevity. Because Vg is synthesized in fat body cells in honey bees,
the team decided to look at Vg expression in the head and thorax as well as the abdomen.
http://www.news.uiuc.edu/news/07/0508queenbee.html
Low-calorie diet effective later in life
Reducing calorie intake later in life can still induce many health and longevity
benefits, University of California researchers report.
http://www.upi.com/ConsumerHealthDaily/view.php?StoryID=20070404-052040-5628r
Lipoic acid explored as anti-aging
compound
Researchers said today they have identified the mechanism of action of lipoic
acid, a remarkable compound that in animal experiments appears to slow down the process of
aging, improve blood flow, enhance immune function and perform many other functions.
http://www.eurekalert.org/pub_releases/2007-05/osu-lae051707.php
Corn, oats, cherries and red wine’s
high melatonin content can help delay ageing
A study carried out by researchers from the University of Granada’s Institute of
Biotechnology proves that consuming melatonin neutralizes oxidative damage and delays the
neurodegenerative process of ageing. - In this study researchers used normal and
genetically-modified mice which were subjected to accelerated cell ageing, although their
results can also be applied to humans.
http://prensa.ugr.es/prensa/research/verNota/prensa.php?nota=427
Aging, Adiposity, and Calorie
Restriction
Calorie restriction in adult men and women causes beneficial
metabolic, hormonal, and functional changes, but the precise amount of calorie intake or
body fat mass associated with optimalhealth and maximum longevity in humans is not known.
In addition, it is possible that even moderate calorie restriction may be harmful in
specific patient populations, such as lean persons who have minimalamounts of body fat.
http://jama.ama-assn.org/cgi/content/short/297/9/986?rss=1
Reducing insulin signaling in the brain
can prolong lifespan
A study from Children's Hospital Boston finds that reducing
insulin levels in the brain boosts longevity. Though it was done in genetically engineered
mice, old-fashioned exercise and good diets also keep brain insulin levels low in humans.
http://www.childrenshospital.org/newsroom/Site1339/mainpageS1339P1sublevel325.html
Eat less, live longer, sure, but
scientists want to know how
A team of scientists at the Pennington Biomedical Research
Center recently made headlines by releasing strong results that indicate if you severely
cut the calories you eat – by up to 25 percent for six months – while
maintaining a nutritious diet, you are likely to be healthier and live longer. They dubbed
the super diet “calorie restriction,” and now that same team wants local
residents to help them learn how it works. Led by Eric Ravussin, Ph.D., the team learned
that several “biomarkers” measured during calorie restriction indicated a slow
down of the aging process. Participants were also healthier, but Ravussin doesn’t yet
know what caused it. “All participants in the calorie restriction study ate less and
exercised more, so they also lost weight. We’re not sure if their bodies reacted
biologically to the decrease in calories or to the weight loss,” Ravussin said.
“That’s what we’re trying to learn now, but we need help.”
http://www.pbrc.edu/News/News_Story.asp?id=69
Pennington Biomedical Research Center's
Caloric Restriction Study
It has been reported for many years that sustained caloric
restriction without nutritional deficiencies increases the length of life and prevents
developement and/or progression of some age-related chronic diseases. The overall purpose
of this study is to gain knowledge about the effects of two years of food restriciton in
reducing the risk of disease associated with aging and in slowing the aging process.
http://calerie.pbrc.edu/introduction.html
Calorie Restriction Reduces Disease and
Extends Life
In literally thousands of experiments, on a wide range
of animals (almost certainly to include humans!), calorie restriction has greatly extended
maximum and average lifespans and improved disease resistance, including resistance to
many cancers. There is still uncertainty about why calorie restriction has these desired
effects. Two important reasons proposed for the benefits of calorie restriction are: 1)
fewer calories mean that there will be a reduction in the accumulation of oxidant and
free-radical damage, and 2) fewer calories alter fat deposition, obesity, and hormones.
The practical effect of this is improve the immune response of calorie-restricted
(hereafter CR) animals. There are numerous reputable websites to learn more about the
underlying animal studies (preliminary corroborative results are now coming out on the
rhesus monkey experiments currently underway). Indeed, there are already convincing
studies demonstrating the health benefits (and, no doubt, the longevity
benefits…though not enough time has passed to observe these!) in humans. See the
Sears and Walford references in the bibliography, and for a fascinating more general
account of why we age check out Austad. For present purposes, that CR—with adequate
or optimal nutrition (the first controversy)--is good for your prospects for a long,
healthy life will be taken as a given. The science is unambiguous and the life extension
benefits have been known (surprisingly) since 1935. The interesting questions revolve
around related issues.
http://spot.colorado.edu/%7Egravesp/DietHealthandLongevity.html
The American Academy of Anti-Aging
Medicine
A4M is a non-profit organization with a membership
of 11,500 physicians and scientists from 65 countries, the American Academy of Anti-Aging
Medicine (A4M) is an organization that is the sole medical society dedicated to the
advancement of therapeutics related to the science of longevity medicine.
http://www.worldhealth.net/
Older Women Need A Little Meat On Their
Bones
It's not a license to pig out, but a recent
study found that women considered overweight by some measures had lower mortality than
their skinnier counterparts. A study of more than 8,000 women ages 65 and older
participating in the Study of Osteoporotic Fractures found those with body mass indexes
(BMI) ranging from 24.6-29.8 kg/m2 had the lowest mortality. BMI charts typically place
women with a BMI of 25-29.9 kg/m2 as overweight. [Ben Licher]
http://www.medicalnewstoday.com/medicalnews.php?newsid=65853&nfid=rssfeeds
The food additives 'that could put ten
years on your life'
A visiting professor at Oxford University
suggests that eating food enhanced with isotopes could be the holy grail of defying the
ageing process.
http://www.dailymail.co.uk/pages/live/articles/health/
healthmain.html?in_article_id=444558&in_page_id=1774
Fight aging
We are on the verge of a revolution in
medicine; understanding, treating, and ultimately preventing the causes of degenerative
aging. But medical revolutions only happen if we all stand up in support of funding and
research. We did it for cancer. We're doing it for Alzheimer's. We can do it for aging -
and create an era of longer, healthier lives!"
http://www.fightaging.org/
Salk researchers discover first gene
that specifically links calorie restriction to longevity
In studies going back to the
1930s, mice and many other species subsisting on a severely calorie-restricted diet have
consistently outlived their well-fed peers by as much as 40 percent. But just how a diet
verging on the brink of starvation extends lifespan has remained elusive.
http://www.salk.edu/news/releases/details_20070502b.php
Extreme dieting - Eat less, live longer?
Scientists believe they are a
step closer to working out why an extremely restrictive diet boosts longevity. This
well-documented calorie-cutting phenomenon has been seen in many species, from yeast to
mice to dogs.
http://news.bbc.co.uk/1/hi/sci/tech/6617113.stm
